ES545170A0 - Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral. - Google Patents
Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral.Info
- Publication number
- ES545170A0 ES545170A0 ES545170A ES545170A ES545170A0 ES 545170 A0 ES545170 A0 ES 545170A0 ES 545170 A ES545170 A ES 545170A ES 545170 A ES545170 A ES 545170A ES 545170 A0 ES545170 A0 ES 545170A0
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- acid amides
- procedure
- preparation
- antitumoral activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical group C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000004957 immunoregulator effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59145731A JPH0662529B2 (ja) | 1984-07-13 | 1984-07-13 | アミノ酸誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES545170A0 true ES545170A0 (es) | 1987-03-01 |
| ES8703830A1 ES8703830A1 (es) | 1987-03-01 |
Family
ID=15391835
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES545170A Expired ES8703830A1 (es) | 1984-07-13 | 1985-07-12 | Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral. |
| ES557197A Expired ES8801186A1 (es) | 1984-07-13 | 1986-11-13 | Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral |
| ES557196A Expired ES8801185A1 (es) | 1984-07-13 | 1986-11-13 | Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557197A Expired ES8801186A1 (es) | 1984-07-13 | 1986-11-13 | Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral |
| ES557196A Expired ES8801185A1 (es) | 1984-07-13 | 1986-11-13 | Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4904680A (es) |
| EP (1) | EP0173441B1 (es) |
| JP (1) | JPH0662529B2 (es) |
| AT (1) | ATE49749T1 (es) |
| CA (1) | CA1283917C (es) |
| DE (1) | DE3575554D1 (es) |
| ES (3) | ES8703830A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01250370A (ja) * | 1987-12-23 | 1989-10-05 | Zeria Pharmaceut Co Ltd | 新規アミノ酸イミド誘導体、製法ならびに用途 |
| FR2646847B1 (fr) * | 1989-05-12 | 1991-07-12 | Rhone Poulenc Sante | N-phenyl amides, leurs procedes de preparation et les medicaments les contenant |
| JPH0524090U (ja) * | 1991-09-20 | 1993-03-30 | 仲秋 張 | ジグソーパズル |
| HU211995B (en) * | 1992-06-30 | 1996-01-29 | Gyogyszerkutato Intezet | Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them |
| US5854250A (en) * | 1995-10-11 | 1998-12-29 | Gyogyszerkutato Intezet Kft | N-benzoylamino acid derivatives, pharmaceutical compositions containing them and process of preparing same |
| CN1261878A (zh) * | 1997-05-07 | 2000-08-02 | 柏林马克斯普朗克科学促进协会 | 新的半胱氨酸衍生物,它们的制备方法和含有它们的药物 |
| WO1999031066A1 (en) * | 1997-12-18 | 1999-06-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyridones as src family sh2 domain inhibitors |
| US7427496B2 (en) * | 1999-06-25 | 2008-09-23 | The Regents Of The University Of Colorado | Anti-cancer compounds |
| AU2001252958A1 (en) | 2000-03-23 | 2001-10-03 | Elan Pharmaceuticals, Inc. | Compounds and methods to treat alzheimer's disease |
| US6846813B2 (en) | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| CA2410680A1 (en) | 2000-06-30 | 2002-01-10 | Elan Pharmaceuticals, Inc. | Compounds to treat alzheimer's disease |
| CA2452039A1 (en) | 2001-06-27 | 2003-01-09 | Elan Pharmaceuticals, Inc. | Beta-hydroxyamine derivatives useful in treatment of alzheimer's disease |
| KR20040095311A (ko) * | 2002-03-28 | 2004-11-12 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 프로스타글란딘 ｆ 수용체의 모듈레이터로서의 티아졸리딘카르복사미드 유도체 |
| DE102005028492A1 (de) * | 2005-06-20 | 2006-12-28 | Basf Ag | Verfahren zur Herstellung von optisch aktiven Aminoalkylphenolen |
| BR112020004800A2 (pt) * | 2017-09-13 | 2020-09-24 | Amgen Inc. | compostos de bisamida ativantes do sarcômero e seus usos |
| CN117945945A (zh) * | 2022-10-28 | 2024-04-30 | 浙江友宁生物医药科技有限公司 | 一种gpr139受体激动剂、其制备方法及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE213641C (es) * | ||||
| DE363467C (de) | 1917-11-21 | 1922-11-09 | Physikalisch Chemische Werke A | Trockenelement, bei dem zwei verdickte Elektrolyte, von denen jeder eine Elektrode enthaelt, durch ein Kohlediaphragma voneinander getrennt sind |
| DE1236519B (de) * | 1959-09-19 | 1967-03-16 | Nippon Shinyaku Co Ltd | Verfahren zum Herstellen eines analgetisch wirksamen Salicylsaeure-Derivates |
| DE1793613A1 (de) * | 1966-05-13 | 1971-09-02 | Francia Farma | gamma-Orthohydroxybenzamidbutyramid |
| CH513123A (de) * | 1967-09-25 | 1971-09-30 | Bayer Ag | Verfahren zur Herstellung von N-Acyl-a-aminosäureamiden bzw. -peptiden |
| IE33790B1 (en) * | 1968-06-04 | 1974-10-30 | Beecham Group Ltd | Derivatives of n-acylaminoacid amides |
| DE2139641A1 (de) * | 1971-08-07 | 1973-02-15 | Bayer Ag | 2-(p-chlorbenzoylamino)-carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| AU518147B2 (en) * | 1976-12-03 | 1981-09-17 | E.R. Squibb & Sons, Inc. | Derivatives of thiazolidine, thiazine and morpholine carboxylic acids |
| EP0059536B1 (en) * | 1981-03-04 | 1987-04-22 | Imperial Chemical Industries Plc | Amide derivatives, processes for preparing them, their use as fungicides and pesticidal compositions containing them |
-
1984
- 1984-07-13 JP JP59145731A patent/JPH0662529B2/ja not_active Expired - Fee Related
-
1985
- 1985-07-12 ES ES545170A patent/ES8703830A1/es not_active Expired
- 1985-07-15 CA CA000486792A patent/CA1283917C/en not_active Expired - Fee Related
- 1985-07-15 EP EP85305052A patent/EP0173441B1/en not_active Expired - Lifetime
- 1985-07-15 AT AT85305052T patent/ATE49749T1/de not_active IP Right Cessation
- 1985-07-15 DE DE8585305052T patent/DE3575554D1/de not_active Expired - Fee Related
-
1986
- 1986-11-13 ES ES557197A patent/ES8801186A1/es not_active Expired
- 1986-11-13 ES ES557196A patent/ES8801185A1/es not_active Expired
-
1988
- 1988-01-22 US US07/146,955 patent/US4904680A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0173441A1 (en) | 1986-03-05 |
| CA1283917C (en) | 1991-05-07 |
| US4904680A (en) | 1990-02-27 |
| ES8703830A1 (es) | 1987-03-01 |
| DE3575554D1 (de) | 1990-03-01 |
| ATE49749T1 (de) | 1990-02-15 |
| EP0173441B1 (en) | 1990-01-24 |
| JPS6124550A (ja) | 1986-02-03 |
| ES557196A0 (es) | 1988-01-01 |
| ES557197A0 (es) | 1988-01-01 |
| ES8801186A1 (es) | 1988-01-01 |
| JPH0662529B2 (ja) | 1994-08-17 |
| ES8801185A1 (es) | 1988-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970612 |