ES551768A0 - Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo - Google Patents
Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metiloInfo
- Publication number
- ES551768A0 ES551768A0 ES551768A ES551768A ES551768A0 ES 551768 A0 ES551768 A0 ES 551768A0 ES 551768 A ES551768 A ES 551768A ES 551768 A ES551768 A ES 551768A ES 551768 A0 ES551768 A0 ES 551768A0
- Authority
- ES
- Spain
- Prior art keywords
- nitrophenyl
- dimethyl
- isomer
- methyl
- diastereoisomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 M-NITROPHENYL Chemical class 0.000 title 1
- 230000003287 optical effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- VXMOONUMYLCFJD-UHFFFAOYSA-N mepirodipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC2CN(CC=3C=CC=CC=3)CC2)C1C1=CC=CC([N+]([O-])=O)=C1 VXMOONUMYLCFJD-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7599884A JPS60231673A (ja) | 1984-04-16 | 1984-04-16 | Ｙｍ−０９７３０のジアステレオマーａまたはその酸付加塩、該化合物の製造方法および該化合物からなる医薬 |
| JP59114098A JPS60258179A (ja) | 1984-06-04 | 1984-06-04 | Ｙｍ−０９７３０のジアステレオマ−ａの右旋性光学異性体またはその酸付加塩，該化合物の製造方法および該化合物からなる医薬 |
| JP59165793A JPS6143187A (ja) | 1984-08-07 | 1984-08-07 | Ｙｍ−０９７３０のジアステレオマ−ａの右旋性光学異性体の新規製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8707522A1 ES8707522A1 (es) | 1987-08-01 |
| ES551768A0 true ES551768A0 (es) | 1987-08-01 |
Family
ID=27302015
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542253A Expired ES8608512A1 (es) | 1984-04-16 | 1985-04-15 | Un procedimiento para la preparacion del diastereoisomero de 2,dimetil-4-(m-nitrofenil) 1,4-dihidropiridin-3,5-dicarboxilamato de 3-(1-bencilpirrolidin-3-iio) y 5 metilo |
| ES551767A Expired ES8704937A1 (es) | 1984-04-16 | 1986-02-07 | Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4(m-nitrofenil)-1,4-dihidropiridin-3,5-ciarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo |
| ES551768A Expired ES8707522A1 (es) | 1984-04-16 | 1986-02-07 | Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo |
| ES551769A Expired ES8704866A1 (es) | 1984-04-16 | 1986-02-07 | Un procedimiento para la preparacion del diastereomero a de 2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542253A Expired ES8608512A1 (es) | 1984-04-16 | 1985-04-15 | Un procedimiento para la preparacion del diastereoisomero de 2,dimetil-4-(m-nitrofenil) 1,4-dihidropiridin-3,5-dicarboxilamato de 3-(1-bencilpirrolidin-3-iio) y 5 metilo |
| ES551767A Expired ES8704937A1 (es) | 1984-04-16 | 1986-02-07 | Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4(m-nitrofenil)-1,4-dihidropiridin-3,5-ciarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES551769A Expired ES8704866A1 (es) | 1984-04-16 | 1986-02-07 | Un procedimiento para la preparacion del diastereomero a de 2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0160451B1 (es) |
| KR (1) | KR920003626B1 (es) |
| AT (1) | ATE66677T1 (es) |
| AU (1) | AU569618B2 (es) |
| CA (2) | CA1273930A (es) |
| DE (1) | DE3583882D1 (es) |
| DK (1) | DK166386C (es) |
| ES (4) | ES8608512A1 (es) |
| GR (1) | GR850872B (es) |
| IE (1) | IE57811B1 (es) |
| MX (1) | MX7363E (es) |
| NL (1) | NL990023I2 (es) |
| NO (1) | NO159594C (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9405833D0 (en) * | 1994-03-24 | 1994-05-11 | Pfizer Ltd | Separation of the enantiomers of amlodipine |
| DE4443168A1 (de) * | 1994-12-05 | 1996-06-13 | Bayer Ag | Neues hochselektives Verfahren zur Herstellung von enantiomerenreinen phenylsubstituierten 1,4-Dihydropyridin-3,5-dicarbonsäurederivaten |
| KR100939347B1 (ko) | 2005-07-20 | 2010-01-29 | (주)카이로드 | 광학적으로 순수한 (ｓ)-3-히드록시 피롤리딘의 제조방법 |
| ITMI20120513A1 (it) * | 2012-03-29 | 2013-09-30 | Lusochimica Spa | Nuove forme polimorfe della barnidipina cloridrato e processi per la loro preparazione |
| EP4382529A1 (en) | 2022-12-07 | 2024-06-12 | Bayer Consumer Care AG | A process for preparing pure (3s)-pyrrolidin-3-ol and pure (3s)-pyrrolidin-3-ol hydrochloride |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55301A (en) * | 1978-02-14 | 1980-01-05 | Yamanouchi Pharmaceut Co Ltd | 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation |
-
1985
- 1985-04-08 GR GR850872A patent/GR850872B/el not_active IP Right Cessation
- 1985-04-13 KR KR1019850002490A patent/KR920003626B1/ko not_active Expired
- 1985-04-15 ES ES542253A patent/ES8608512A1/es not_active Expired
- 1985-04-15 DK DK169185A patent/DK166386C/da not_active IP Right Cessation
- 1985-04-15 NO NO851494A patent/NO159594C/no not_active IP Right Cessation
- 1985-04-16 DE DE85302666T patent/DE3583882D1/de not_active Expired - Lifetime
- 1985-04-16 CA CA000479294A patent/CA1273930A/en not_active Expired - Lifetime
- 1985-04-16 AT AT85302666T patent/ATE66677T1/de not_active IP Right Cessation
- 1985-04-16 EP EP85302666A patent/EP0160451B1/en not_active Expired - Lifetime
- 1985-04-16 MX MX8511525U patent/MX7363E/es unknown
- 1985-04-16 IE IE985/85A patent/IE57811B1/en not_active IP Right Cessation
- 1985-04-16 AU AU41318/85A patent/AU569618B2/en not_active Expired
-
1986
- 1986-02-07 ES ES551767A patent/ES8704937A1/es not_active Expired
- 1986-02-07 ES ES551768A patent/ES8707522A1/es not_active Expired
- 1986-02-07 ES ES551769A patent/ES8704866A1/es not_active Expired
-
1990
- 1990-05-25 CA CA000615749A patent/CA1289565C/en not_active Expired - Lifetime
-
1999
- 1999-07-30 NL NL990023C patent/NL990023I2/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0160451A2 (en) | 1985-11-06 |
| ES551769A0 (es) | 1987-04-16 |
| ES8608512A1 (es) | 1986-07-01 |
| EP0160451A3 (en) | 1987-07-08 |
| ES8707522A1 (es) | 1987-08-01 |
| IE57811B1 (en) | 1993-04-21 |
| KR860008162A (ko) | 1986-11-12 |
| CA1289565C (en) | 1991-09-24 |
| NL990023I2 (nl) | 1999-12-01 |
| NL990023I1 (nl) | 1999-10-01 |
| DK166386B (da) | 1993-05-10 |
| NO159594C (no) | 1989-01-18 |
| DK169185D0 (da) | 1985-04-15 |
| ES8704937A1 (es) | 1987-04-16 |
| CA1273930A (en) | 1990-09-11 |
| MX7363E (es) | 1988-08-04 |
| DE3583882D1 (es) | 1991-10-02 |
| ES8704866A1 (es) | 1987-04-16 |
| KR920003626B1 (ko) | 1992-05-04 |
| AU4131885A (en) | 1985-10-24 |
| IE850985L (en) | 1985-10-25 |
| AU569618B2 (en) | 1988-02-11 |
| DK166386C (da) | 1993-09-27 |
| ES542253A0 (es) | 1986-07-01 |
| ES551767A0 (es) | 1987-04-16 |
| GR850872B (es) | 1985-11-25 |
| NO159594B (no) | 1988-10-10 |
| EP0160451B1 (en) | 1991-08-28 |
| ATE66677T1 (de) | 1991-09-15 |
| NO851494L (no) | 1985-10-17 |
| DK169185A (da) | 1985-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20070219 |