ES552684A0 - Un procedimiento para la obtencion de derivados 4-(1-(5,6,7,8-tetrahidropirido (2,3-d)pirimidin-6-il) alquil-2) benzoil de acido l-glutamico. - Google Patents

Un procedimiento para la obtencion de derivados 4-(1-(5,6,7,8-tetrahidropirido (2,3-d)pirimidin-6-il) alquil-2) benzoil de acido l-glutamico.

Info

Publication number: ES552684A0
Authority: ES; Spain
Prior art keywords: glutamic acid; tetrahidropirido; alquil; pirimidin; benzoil
Prior art date: 1985-03-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES552684A

Other languages

English (en)

Other versions

ES8704167A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Princeton University

Original Assignee

Princeton University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-08

Filing date

1986-03-05

Publication date

1987-03-16

1986-03-05 Application filed by Princeton University filed Critical Princeton University

1987-03-16 Publication of ES8704167A1 publication Critical patent/ES8704167A1/es

1987-03-16 Publication of ES552684A0 publication Critical patent/ES552684A0/es

Status Expired legal-status Critical Current

Links

229960002989 glutamic acid Drugs 0.000 title abstract 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 title 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
229940034982 antineoplastic agent Drugs 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000006244 carboxylic acid protecting group Chemical group 0.000 abstract 1
150000002306 glutamic acid derivatives Chemical class 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Cosmetics (AREA)

ES552684A 1985-03-08 1986-03-05 Un procedimiento para la obtencion de derivados 4-(1-(5,6,7,8-tetrahidropirido (2,3-d)pirimidin-6-il) alquil-2) benzoil de acido l-glutamico. Expired ES8704167A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US70962285A	1985-03-08	1985-03-08

Publications (2)

Publication Number	Publication Date
ES8704167A1 ES8704167A1 (es)	1987-03-16
ES552684A0 true ES552684A0 (es)	1987-03-16

Family

ID=24850641

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES552684A Expired ES8704167A1 (es)	1985-03-08	1986-03-05	Un procedimiento para la obtencion de derivados 4-(1-(5,6,7,8-tetrahidropirido (2,3-d)pirimidin-6-il) alquil-2) benzoil de acido l-glutamico.
ES557174A Expired ES8801268A1 (es)	1985-03-08	1986-10-31	Un procedimiento para la obtencion de derivados 4-(2-pirido(2,3-d)pirimidin-6-il)alquil-2)benzoil de acido l-glutamico

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES557174A Expired ES8801268A1 (es)	1985-03-08	1986-10-31	Un procedimiento para la obtencion de derivados 4-(2-pirido(2,3-d)pirimidin-6-il)alquil-2)benzoil de acido l-glutamico

Country Status (22)

Country	Link
EP (1)	EP0215063B1 (es)
JP (2)	JPH0822860B2 (es)
KR (1)	KR940002952B1 (es)
CN (1)	CN1016174B (es)
AT (1)	ATE96790T1 (es)
AU (1)	AU578813B2 (es)
CA (1)	CA1276637C (es)
DE (1)	DE3689250T2 (es)
DK (1)	DK168666B1 (es)
EG (1)	EG18371A (es)
ES (2)	ES8704167A1 (es)
GR (1)	GR860592B (es)
HU (1)	HU196202B (es)
IE (1)	IE63653B1 (es)
IL (1)	IL78059A (es)
MX (1)	MX9203357A (es)
NZ (1)	NZ215404A (es)
PH (1)	PH23136A (es)
PT (1)	PT82149B (es)
SU (1)	SU1676449A3 (es)
WO (1)	WO1986005181A1 (es)
ZA (1)	ZA861235B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ219971A (en) *	1986-06-06	1989-08-29	Univ Princeton	Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
IE60038B1 (en) *	1986-06-30	1994-05-18	Univ Princeton	4(3H)-oxo-5, 6, 7, 8-tetrahydropyrido-[2, 3-d]pyrimidine derivatives
US4818819A (en) *	1986-10-20	1989-04-04	The Trustees Of Princeton University	Process for the preparation of fused pyridine compounds
GB8702758D0 (en) *	1987-02-06	1987-03-11	Wellcome Found	Treatment of disease
EP0278686A1 (en) *	1987-02-07	1988-08-17	The Wellcome Foundation Limited	Pyridopyrimidines methods for their preparation and pharmaceutical formulations thereof
EP0305667A3 (en) *	1987-09-03	1989-10-25	American Cyanamid Company	Improved process for producing 5,10-dideaza-(5,6,7,8)-tetrahydrofolic acid
US4895946A (en) *	1987-10-26	1990-01-23	The Trustees Of Princeton University	Process for the preparation of fused pyridine compounds
US4889859A (en) *	1988-02-05	1989-12-26	The Trustees Of Princeton University	Pyrido[2,3-d]pyrimidine derivatives
DK172753B1 (da) *	1988-05-25	1999-06-28	Lilly Co Eli	N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
JPH03173890A (ja) *	1989-09-21	1991-07-29	Takeda Chem Ind Ltd	ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
CA2066898A1 (en) *	1991-04-29	1992-10-30	Chuan Shih	Pharmaceutical compounds
US5196424A (en) *	1992-03-24	1993-03-23	Eli Lilly And Company	N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids
WO1993020075A1 (en) *	1992-04-01	1993-10-14	The University Of Sydney	8-substituted-n5-deazapterins as antifolates
CZ66893A3 (en) *	1992-04-23	1993-12-15	Lilly Co Eli	Application of gar - transformylase inhibitor
EP0638079B1 (en) *	1992-04-29	1999-12-15	Sri International	Deazaaminopterins for treatment of inflammation
CN1046285C (zh) *	1993-01-29	1999-11-10	阿格罗尼制药公司	作为抗增殖剂的稠合杂环谷氨酸衍生物
US5594139A (en) *	1993-01-29	1997-01-14	Agouron Pharmaceuticals, Inc.	Processes for preparing antiproliferative garft-inhibiting compounds
SG44827A1 (en) *	1994-07-28	1997-12-19	Agouron Pharma	Compounds useful as antiproliferative agents and garft inhibitors
CN1053448C (zh) *	1994-07-28	2000-06-14	阿格罗尼制药公司	用作抗增殖药物及garft抑制剂的化合物
US5831100A (en) *	1995-06-07	1998-11-03	Agouron Pharmaceuticals, Inc.	Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
MXPA01012206A (es)	1999-05-24	2002-06-21	Sankyo Co	Composiciones farmaceuticas que contienen anticuerpo anti-fas.
ES3029483T3 (en) *	2008-09-17	2025-06-24	Endocyte Inc	Folate receptor binding conjugates of antifolates
CN116333411B (zh) *	2023-05-29	2023-08-11	石家庄启宏新材料制品有限公司	一种阻燃eva保温材料及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4512992A (en) *	1980-06-13	1985-04-23	Burroughs Wellcome Co.	Treatment with dialkoxy pyridopyrimidine compounds
US4526964A (en) *	1982-01-11	1985-07-02	Southern Research Institute	2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine
US4431805A (en) *	1981-09-25	1984-02-14	Southern Research Institute	Pyrido[2,3-d]-pyrimidines
US4536575A (en) *	1982-01-11	1985-08-20	Southern Research Institute	2-Amino-4(3H)-oxopyrido[2,3-d]pyrimidino
US4532241A (en) *	1982-08-26	1985-07-30	Sri International	8,10-Dideazaminopterins
US4460591A (en) *	1982-08-26	1984-07-17	Sri International	8,10-Dideazaminopterins
US4432981A (en) *	1982-11-05	1984-02-21	Sterling Drug Inc.	2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones
EP0166726B1 (en) *	1983-12-27	1988-11-17	Sri International	10-ethyl-8,10-dideazaminopterins

1986
- 1986-02-19 ZA ZA861235A patent/ZA861235B/xx unknown
- 1986-02-24 KR KR1019860700771A patent/KR940002952B1/ko not_active Expired - Fee Related
- 1986-02-24 AU AU55108/86A patent/AU578813B2/en not_active Ceased
- 1986-02-24 AT AT86901675T patent/ATE96790T1/de not_active IP Right Cessation
- 1986-02-24 DE DE86901675T patent/DE3689250T2/de not_active Expired - Fee Related
- 1986-02-24 EP EP86901675A patent/EP0215063B1/en not_active Expired - Lifetime
- 1986-02-24 JP JP61501296A patent/JPH0822860B2/ja not_active Expired - Fee Related
- 1986-02-24 WO PCT/US1986/000368 patent/WO1986005181A1/en not_active Ceased
- 1986-02-24 HU HU862011A patent/HU196202B/hu not_active IP Right Cessation
- 1986-03-03 GR GR860592A patent/GR860592B/el unknown
- 1986-03-03 IE IE56186A patent/IE63653B1/en not_active IP Right Cessation
- 1986-03-05 ES ES552684A patent/ES8704167A1/es not_active Expired
- 1986-03-06 EG EG107/86A patent/EG18371A/xx active
- 1986-03-06 PT PT82149A patent/PT82149B/pt not_active IP Right Cessation
- 1986-03-06 IL IL78059A patent/IL78059A/xx unknown
- 1986-03-07 PH PH33489A patent/PH23136A/en unknown
- 1986-03-07 CA CA000503509A patent/CA1276637C/en not_active Expired - Lifetime
- 1986-03-07 NZ NZ215404A patent/NZ215404A/xx unknown
- 1986-03-08 CN CN86101475A patent/CN1016174B/zh not_active Expired
- 1986-10-02 DK DK472186A patent/DK168666B1/da not_active IP Right Cessation
- 1986-10-31 ES ES557174A patent/ES8801268A1/es not_active Expired
- 1986-11-03 SU SU864028461A patent/SU1676449A3/ru active
1992
- 1992-06-25 MX MX9203357A patent/MX9203357A/es unknown
1995
- 1995-09-05 JP JP7228382A patent/JPH08193084A/ja active Pending

Also Published As

Publication number	Publication date
AU578813B2 (en)	1988-11-03
WO1986005181A1 (en)	1986-09-12
IL78059A (en)	1989-06-30
IL78059A0 (en)	1986-07-31
EG18371A (en)	1993-04-30
EP0215063B1 (en)	1993-11-03
HU196202B (en)	1988-10-28
DK168666B1 (da)	1994-05-16
DE3689250D1 (de)	1993-12-09
ES8704167A1 (es)	1987-03-16
ATE96790T1 (de)	1993-11-15
CN1016174B (zh)	1992-04-08
JPH08193084A (ja)	1996-07-30
DK472186D0 (da)	1986-10-02
PT82149A (en)	1986-04-01
KR870700067A (ko)	1987-02-28
JPH0822860B2 (ja)	1996-03-06
EP0215063A1 (en)	1987-03-25
AU5510886A (en)	1986-09-24
CA1276637C (en)	1990-11-20
DE3689250T2 (de)	1994-03-03
ES557174A0 (es)	1987-12-16
SU1676449A3 (ru)	1991-09-07
IE860561L (en)	1986-09-08
JPS62502535A (ja)	1987-10-01
MX9203357A (es)	1992-07-01
IE63653B1 (en)	1995-05-31
HUT41785A (en)	1987-05-28
KR940002952B1 (ko)	1994-04-09
GR860592B (en)	1986-06-26
DK472186A (da)	1986-12-19
EP0215063A4 (en)	1987-11-23
NZ215404A (en)	1990-03-27
ES8801268A1 (es)	1987-12-16
CN86101475A (zh)	1987-01-21
PH23136A (en)	1989-05-11
PT82149B (pt)	1988-04-21
ZA861235B (en)	1986-10-29

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Legal Events

Date	Code	Title	Description
2006-11-16	FD1A	Patent lapsed	Effective date: 20050131