ATE96790T1 - Pyrido-(-2,3-d-)-pyrimidinabkoemmlinge. - Google Patents

Pyrido-(-2,3-d-)-pyrimidinabkoemmlinge.

Info

Publication number
ATE96790T1
ATE96790T1 AT86901675T AT86901675T ATE96790T1 AT E96790 T1 ATE96790 T1 AT E96790T1 AT 86901675 T AT86901675 T AT 86901675T AT 86901675 T AT86901675 T AT 86901675T AT E96790 T1 ATE96790 T1 AT E96790T1
Authority
AT
Austria
Prior art keywords
pyrido
pyrimidin
benzoyl
hydroxy
amino
Prior art date
Application number
AT86901675T
Other languages
English (en)
Inventor
Edward C Taylor
George Peter Beardsley
Peter J Harrington
Stephen R Fletcher
Original Assignee
Univ Princeton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Princeton filed Critical Univ Princeton
Application granted granted Critical
Publication of ATE96790T1 publication Critical patent/ATE96790T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
AT86901675T 1985-03-08 1986-02-24 Pyrido-(-2,3-d-)-pyrimidinabkoemmlinge. ATE96790T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70962285A 1985-03-08 1985-03-08
PCT/US1986/000368 WO1986005181A1 (en) 1985-03-08 1986-02-24 PYRIDO AD2,3-d BDPYRIMIDIN DERIVATIVES
EP86901675A EP0215063B1 (de) 1985-03-08 1986-02-24 Pyrido-(-2,3-d-)-pyrimidinabkömmlinge

Publications (1)

Publication Number Publication Date
ATE96790T1 true ATE96790T1 (de) 1993-11-15

Family

ID=24850641

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86901675T ATE96790T1 (de) 1985-03-08 1986-02-24 Pyrido-(-2,3-d-)-pyrimidinabkoemmlinge.

Country Status (22)

Country Link
EP (1) EP0215063B1 (de)
JP (2) JPH0822860B2 (de)
KR (1) KR940002952B1 (de)
CN (1) CN1016174B (de)
AT (1) ATE96790T1 (de)
AU (1) AU578813B2 (de)
CA (1) CA1276637C (de)
DE (1) DE3689250T2 (de)
DK (1) DK168666B1 (de)
EG (1) EG18371A (de)
ES (2) ES8704167A1 (de)
GR (1) GR860592B (de)
HU (1) HU196202B (de)
IE (1) IE63653B1 (de)
IL (1) IL78059A (de)
MX (1) MX9203357A (de)
NZ (1) NZ215404A (de)
PH (1) PH23136A (de)
PT (1) PT82149B (de)
SU (1) SU1676449A3 (de)
WO (1) WO1986005181A1 (de)
ZA (1) ZA861235B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
IE60038B1 (en) * 1986-06-30 1994-05-18 Univ Princeton 4(3H)-oxo-5, 6, 7, 8-tetrahydropyrido-[2, 3-d]pyrimidine derivatives
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
GB8702758D0 (en) * 1987-02-06 1987-03-11 Wellcome Found Treatment of disease
EP0278686A1 (de) * 1987-02-07 1988-08-17 The Wellcome Foundation Limited Pyridopyrimidine, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen davon
EP0305667A3 (de) * 1987-09-03 1989-10-25 American Cyanamid Company Verfahren zur Herstellung von 5,10-Dideaza-(5,6,7,8)-tetrahydrofolicsäure
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4889859A (en) * 1988-02-05 1989-12-26 The Trustees Of Princeton University Pyrido[2,3-d]pyrimidine derivatives
DK172753B1 (da) * 1988-05-25 1999-06-28 Lilly Co Eli N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
CA2066898A1 (en) * 1991-04-29 1992-10-30 Chuan Shih Pharmaceutical compounds
US5196424A (en) * 1992-03-24 1993-03-23 Eli Lilly And Company N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids
WO1993020075A1 (en) * 1992-04-01 1993-10-14 The University Of Sydney 8-substituted-n5-deazapterins as antifolates
ZA932731B (en) * 1992-04-23 1994-10-19 Lilly Co Eli Method of treating gar-transformylase-dependent tumors
EP0638079B1 (de) * 1992-04-29 1999-12-15 Sri International Deazaaminopterine für behandlung von entzündungen
US5594139A (en) * 1993-01-29 1997-01-14 Agouron Pharmaceuticals, Inc. Processes for preparing antiproliferative garft-inhibiting compounds
SG49234A1 (en) * 1993-01-29 1998-05-18 Agouron Pharma Condensed heterocyclic glutamic acid derivatives as antiproliferative agents
CN1053448C (zh) * 1994-07-28 2000-06-14 阿格罗尼制药公司 用作抗增殖药物及garft抑制剂的化合物
RU2136686C1 (ru) * 1994-07-28 1999-09-10 Агурон Фармасьютикалз, Инк. Производные глутаминовой кислоты (варианты), фармацевтическая композиция, способ ингибирования роста и пролиферации клеток, производные тиофенкарбоновой кислоты (варианты)
US5831100A (en) * 1995-06-07 1998-11-03 Agouron Pharmaceuticals, Inc. Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
EP1180369A4 (de) 1999-05-24 2002-07-24 Sankyo Co ANTI-Fas ANTIKÖRPER ENTHALTENDE MEDIZINISCHE ZUSAMMENSETZUNGEN
ES3029483T3 (en) 2008-09-17 2025-06-24 Endocyte Inc Folate receptor binding conjugates of antifolates
CN116333411B (zh) * 2023-05-29 2023-08-11 石家庄启宏新材料制品有限公司 一种阻燃eva保温材料及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4512992A (en) * 1980-06-13 1985-04-23 Burroughs Wellcome Co. Treatment with dialkoxy pyridopyrimidine compounds
US4431805A (en) * 1981-09-25 1984-02-14 Southern Research Institute Pyrido[2,3-d]-pyrimidines
US4526964A (en) * 1982-01-11 1985-07-02 Southern Research Institute 2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine
US4536575A (en) * 1982-01-11 1985-08-20 Southern Research Institute 2-Amino-4(3H)-oxopyrido[2,3-d]pyrimidino
US4532241A (en) * 1982-08-26 1985-07-30 Sri International 8,10-Dideazaminopterins
US4460591A (en) * 1982-08-26 1984-07-17 Sri International 8,10-Dideazaminopterins
US4432981A (en) * 1982-11-05 1984-02-21 Sterling Drug Inc. 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones
EP0166726B1 (de) * 1983-12-27 1988-11-17 Sri International 10-ethyl-8,10-dideazaminopterine

Also Published As

Publication number Publication date
EP0215063A4 (de) 1987-11-23
EP0215063A1 (de) 1987-03-25
WO1986005181A1 (en) 1986-09-12
ES8801268A1 (es) 1987-12-16
PH23136A (en) 1989-05-11
IE63653B1 (en) 1995-05-31
IL78059A (en) 1989-06-30
CN1016174B (zh) 1992-04-08
PT82149B (pt) 1988-04-21
CA1276637C (en) 1990-11-20
DE3689250D1 (de) 1993-12-09
DE3689250T2 (de) 1994-03-03
KR940002952B1 (ko) 1994-04-09
JPH0822860B2 (ja) 1996-03-06
SU1676449A3 (ru) 1991-09-07
HUT41785A (en) 1987-05-28
DK472186A (da) 1986-12-19
JPS62502535A (ja) 1987-10-01
ES8704167A1 (es) 1987-03-16
ZA861235B (en) 1986-10-29
HU196202B (en) 1988-10-28
EG18371A (en) 1993-04-30
ES557174A0 (es) 1987-12-16
ES552684A0 (es) 1987-03-16
DK472186D0 (da) 1986-10-02
IE860561L (en) 1986-09-08
IL78059A0 (en) 1986-07-31
EP0215063B1 (de) 1993-11-03
JPH08193084A (ja) 1996-07-30
DK168666B1 (da) 1994-05-16
AU5510886A (en) 1986-09-24
GR860592B (en) 1986-06-26
MX9203357A (es) 1992-07-01
KR870700067A (ko) 1987-02-28
PT82149A (en) 1986-04-01
CN86101475A (zh) 1987-01-21
NZ215404A (en) 1990-03-27
AU578813B2 (en) 1988-11-03

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Legal Events

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REN Ceased due to non-payment of the annual fee