ES8103031A1 - Procedimiento para la obtencion de nuevos derivados de gua- nidina - Google Patents

Procedimiento para la obtencion de nuevos derivados de gua- nidina

Info

Publication number
ES8103031A1
ES8103031A1 ES491926A ES491926A ES8103031A1 ES 8103031 A1 ES8103031 A1 ES 8103031A1 ES 491926 A ES491926 A ES 491926A ES 491926 A ES491926 A ES 491926A ES 8103031 A1 ES8103031 A1 ES 8103031A1
Authority
ES
Spain
Prior art keywords
guanidines
compounds
preparation
application
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491926A
Other languages
English (en)
Other versions
ES491926A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8103031A1 publication Critical patent/ES8103031A1/es
Publication of ES491926A0 publication Critical patent/ES491926A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Medicinal Preparation (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE GUANIDINA DE FORMULA (I), EN DONDE PG SIGNIFICA UN RESTO FINILO, EN CASO DADA SUSTITUIDO; R1 Y R2, INDEPENDIENTES ENTRE SI, SIGNIFICAN UN RESTO ALQUILO INFERIROR O CICLOALQUILO, A AMBOS JUNTOS UN RESTO DE HIDROCARBURO BIVALENTE EN CASO DADO SUSTITUIDO, DE CARACTER ALIFATICO, DONDE LOS ATOMOS DE CARBONO DE LA CADENA PUEDEN ESTAR INTERRUMPIDOS POR UN HETEROATOMO; R3 SIGNIFICA HIDROGENO O ALQUILO INFERIOR, DE SUS COMPUESTOS TAUTOMEROS Y DE SUS SALES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN DONDE X1 SIGNIFICA EL GRUPO PH-N=. DONDE PH SIGNIFICA UN RESTO FENILO, EN CASO DADO SUSTITUIDO, O UN GRUPO DISOCIABLE; X2 SIGNIFICA EL GRUPO-NR1R2 DONDE R1 Y R2 TIENEN LOS SIGNIFICADOS INDICADOS ANTERIORMENTE O UN DISOCIABLE; Y X3 SIGNIFICA EL GRUPO DE FORMULA (III), DONDE R3 TIENE EL SIGNIFICADO SEÑALADO ANTERIORMENTE, O ES UN GRUPO DISOCIABLE. DE USO EN PREPARADOS FARMACEUTICOS CON EFEICACIA HIPOGLICEMICA.
ES491926A 1979-05-29 1980-05-28 Procedimiento para la obtencion de nuevos derivados de gua- nidina Granted ES491926A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH499379 1979-05-29

Publications (2)

Publication Number Publication Date
ES8103031A1 true ES8103031A1 (es) 1981-02-16
ES491926A0 ES491926A0 (es) 1981-02-16

Family

ID=4286083

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491926A Granted ES491926A0 (es) 1979-05-29 1980-05-28 Procedimiento para la obtencion de nuevos derivados de gua- nidina

Country Status (21)

Country Link
US (1) US4626537A (es)
EP (1) EP0020303B1 (es)
JP (1) JPS55160764A (es)
KR (2) KR840002309B1 (es)
AT (1) ATE15189T1 (es)
CS (2) CS220327B2 (es)
CY (1) CY1442A (es)
DD (1) DD151163A5 (es)
DE (1) DE3071029D1 (es)
DK (1) DK156059B (es)
ES (1) ES491926A0 (es)
FI (1) FI75154C (es)
GR (1) GR68377B (es)
HK (1) HK80788A (es)
HU (1) HU183145B (es)
IL (1) IL60161A (es)
NO (1) NO153850C (es)
PL (2) PL126790B1 (es)
PT (1) PT71313A (es)
SG (1) SG33688G (es)
SU (2) SU1222191A3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8312665D0 (en) * 1983-05-09 1983-06-15 Ici Plc 4,4'-alkylenedipiperidine derivatives
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
DK0690851T3 (da) * 1993-03-23 1999-11-08 Astra Ab Guanidin-derivater, som er anvendelige til behandling
US6756389B2 (en) * 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
DE60333937D1 (de) * 2002-05-23 2010-10-07 Novartis Vaccines & Diagnostic Substituierte quinazolinone verbindungen
KR20060018217A (ko) 2003-05-23 2006-02-28 카이론 코포레이션 Ｍｃ4-ｒ 작용제로서 구아니디노-치환된 퀴나졸리논 화합물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH513158A (de) * 1967-02-27 1971-09-30 Hoffmann La Roche Verfahren zur Herstellung von Pyrrolinverbindungen
DE2205744A1 (de) * 1972-02-08 1973-08-09 Thomae Gmbh Dr K Neue durch einen guanidinylidenrest substituierte heterocyclen und verfahren zu ihrer herstellung
US3840524A (en) * 1973-04-25 1974-10-08 Richardson Merrell Inc Alpha-cycloalkylbenzyl lactamimides
US4126621A (en) * 1973-08-09 1978-11-21 Richardson-Merrell Inc. Substituted cycloalkyl lactamimides
NZ183570A (en) * 1976-03-19 1979-06-08 Mcneilab Inc Heterocyclic guanidine derivatives, having anti-secretory and hypogliycaemic activity
US4211867A (en) * 1976-03-19 1980-07-08 Mcneil Laboratories, Incorporated Nitrogen heterocyclic carboximidamide compounds
CS225804B2 (cs) * 1976-03-19 1984-02-13 Mcneilab Inc Způsob výroby heterocyklických derivátů guanidinu

Also Published As

Publication number Publication date
IL60161A0 (en) 1980-07-31
IL60161A (en) 1984-05-31
SG33688G (en) 1989-01-27
CS220336B2 (en) 1983-03-25
ATE15189T1 (de) 1985-09-15
KR840002309B1 (ko) 1984-12-17
NO801585L (no) 1980-12-01
KR840002310B1 (ko) 1984-12-17
JPS55160764A (en) 1980-12-13
NO153850B (no) 1986-02-24
PT71313A (de) 1980-06-01
CS220327B2 (en) 1983-03-25
FI75154B (fi) 1988-01-29
PL126790B1 (en) 1983-08-31
SU1227111A3 (ru) 1986-04-23
DK156059B (da) 1989-06-19
US4626537A (en) 1986-12-02
DD151163A5 (de) 1981-10-08
GR68377B (es) 1981-12-28
EP0020303B1 (de) 1985-08-28
DE3071029D1 (en) 1985-10-03
PL124028B1 (en) 1982-12-31
FI75154C (fi) 1988-05-09
NO153850C (no) 1986-06-04
FI801690A7 (fi) 1980-11-30
HK80788A (en) 1988-10-14
KR830002716A (ko) 1983-05-30
PL224523A1 (es) 1981-02-13
HU183145B (en) 1984-04-28
EP0020303A1 (de) 1980-12-10
ES491926A0 (es) 1981-02-16
DK229480A (da) 1980-11-30
SU1222191A3 (ru) 1986-03-30
CY1442A (en) 1989-03-10

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