ES8200687A1 - Un procedimiento para la preparacion de nuevos compuestos amidicos de penicilina - Google Patents

Un procedimiento para la preparacion de nuevos compuestos amidicos de penicilina

Info

Publication number
ES8200687A1
ES8200687A1 ES496567A ES496567A ES8200687A1 ES 8200687 A1 ES8200687 A1 ES 8200687A1 ES 496567 A ES496567 A ES 496567A ES 496567 A ES496567 A ES 496567A ES 8200687 A1 ES8200687 A1 ES 8200687A1
Authority
ES
Spain
Prior art keywords
acylaminoacylamino
aminoacylamino
dihydro
phenyl
oxonicotinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496567A
Other languages
English (en)
Other versions
ES496567A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES8200687A1 publication Critical patent/ES8200687A1/es
Publication of ES496567A0 publication Critical patent/ES496567A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS AMIDICOS DE PENICILINA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES DE FORMULA (I), EN LA QUE R ES (CH2)X,-CO-(CH2)X-N-ACILO O R1-(NR4-ACILO)N, DONDE X VALE 1-5, X'' VALE 0-2, R1 PUEDE SER UNO DE VARIOS RADICALES, R4 ES HIDROGENO O ALCOHILO INFERIOR, N-ACILO ES UN RADICAL AMINOACILO DE UN ACIDO C2-10, Y N VALE 1-4, Y R3 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UNA AMINOACIDOS DE FORMULA (II), SU SAL ACIDA O UN DERIVADO SILILADO DEL MISMO, CON UN DERIVADO REACTIVO DE D-N-(6-(SUSTITUIDO)-1,2-DIHIDRO-2-OXONICOTINIL)-2-SUSTITUIDO-GLICINA, DE FORMULA (III), EN LA QUE R Y R3 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE A TEMPERATURAS COMPRENDIDAS ENTRE -30 Y 30 C. LA SEPARACION Y PURIFICACION DEL PRODUCTO SE EFECTUA SIGUIENDO METODOS CONVENCIONALES.
ES496567A 1979-03-12 1980-11-05 Un procedimiento para la preparacion de nuevos compuestos amidicos de penicilina Granted ES496567A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2000079A 1979-03-12 1979-03-12
US06/112,657 US4278681A (en) 1979-03-12 1980-01-31 Antibacterial amide compounds and means for using the same

Publications (2)

Publication Number Publication Date
ES8200687A1 true ES8200687A1 (es) 1981-11-01
ES496567A0 ES496567A0 (es) 1981-11-01

Family

ID=26692870

Family Applications (2)

Application Number Title Priority Date Filing Date
ES489401A Expired ES8105007A1 (es) 1979-03-12 1980-03-11 Un procedimiento para la preparacion de nuevos compuestos amidicos de penicilina
ES496567A Granted ES496567A0 (es) 1979-03-12 1980-11-05 Un procedimiento para la preparacion de nuevos compuestos amidicos de penicilina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES489401A Expired ES8105007A1 (es) 1979-03-12 1980-03-11 Un procedimiento para la preparacion de nuevos compuestos amidicos de penicilina

Country Status (7)

Country Link
US (1) US4278681A (es)
EP (1) EP0015773B1 (es)
AU (1) AU541984B2 (es)
CA (1) CA1144158A (es)
DE (1) DE3064190D1 (es)
DK (1) DK103680A (es)
ES (2) ES8105007A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382089A (en) * 1982-03-02 1983-05-03 Warner-Lambert Company Antibacterial amide compounds, compositions thereof and methods of using them
US7018988B2 (en) * 2000-03-27 2006-03-28 Applied Research Systems Ars Holding N.V. Pharmaceutically active pyrrolidine derivatives as Bax inhibitors
US7018642B2 (en) * 2001-04-27 2006-03-28 The Procter & Gamble Company Compounds, compositions, and methods for controlling biofilms
WO2016039939A1 (en) * 2014-09-09 2016-03-17 Ptc Therapeutics, Inc. Bicyclic and tricyclic substituted 2-pyridinone antibacterial compounds
WO2016039937A1 (en) * 2014-09-09 2016-03-17 Ptc Therapeutics, Inc. Bicyclic and tricyclic substituted 2-pyridinone antibacterial compounds
EP3787612A4 (en) 2018-05-04 2021-11-17 Remedy Plan, Inc. CANCER TREATMENTS AGAINST CANCER STEM CELLS
PH12022551081A1 (en) 2019-11-06 2024-06-19 Remedy Plan Inc Cancer treatments targeting cancer stem cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873523A (en) * 1972-12-15 1975-03-25 Parke Davis & Co Derivatives of ampicillin
US3954734A (en) * 1974-01-21 1976-05-04 Parke, Davis & Company Novel antibacterial amide compounds and process means for producing the same
US4053470A (en) * 1974-12-23 1977-10-11 Parke, Davis & Company Substituted-1,2-dihydro-2-oxonicotinyl-cephalosporins
US4092309A (en) * 1977-04-27 1978-05-30 Warner-Lambert Company Derivatives of amoxicillin

Also Published As

Publication number Publication date
AU541984B2 (en) 1985-01-31
EP0015773A2 (en) 1980-09-17
EP0015773B1 (en) 1983-07-20
DE3064190D1 (en) 1983-08-25
ES489401A0 (es) 1981-05-16
DK103680A (da) 1980-09-13
EP0015773A3 (en) 1980-11-26
ES8105007A1 (es) 1981-05-16
ES496567A0 (es) 1981-11-01
US4278681A (en) 1981-07-14
AU5634280A (en) 1980-09-18
CA1144158A (en) 1983-04-05

Similar Documents

Publication Publication Date Title
NO175256C (no) Analogifremgangsmåte til fremstilling av terapeutisk aktive 4-oksokinolin-3-karboksylsyrederivater
HK5684A (en) Penicillin derivatives
NO176519C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive heterocykliske ketoner
PT72878A (en) Process for preparing mannich-base hydroxamic acid prodrugs for the improved delivery of non-steroidal anti-inflammatory agents
ES8104233A1 (es) Procedimiento para preparar derivados de acidos quinolina- carboxilicos
FI104076B1 (fi) Menetelmä farmaseuttisesti vaikuttavien triatsolopyridatsiiniyhdisteiden valmistamiseksi
ES8103093A1 (es) Un procedimiento para preparar derivados de oxapenem
TW368501B (en) 7-(2-aminoethyl)-benzothiazolones
EP0062328A3 (en) Novel penicillin and cephalosporin compounds, a process for preparing the same and antibacterial composition containing the novel compounds
ES439017A1 (es) Un procedimiento para la preparacion de nuevas piridinas.
IE781111L (en) Oxo-nicotinyl penicillin and cephalosporin derivatives.
ES8307825A1 (es) "un procedimiento para preparar un compuesto de cefem".
ES8105007A1 (es) Un procedimiento para la preparacion de nuevos compuestos amidicos de penicilina
JPS5612368A (en) Optically pure heterocyclic amino acid compounds* their manufacture and their use for synthesizing drug
FI93459B (fi) Menetelmä terapeuttisesti käyttökelpoisten 6-aryyli-5,6-dihydroimidatso/2,1-b/tiatsolijohdannaisten valmistamiseksi
IE33535B1 (en) New penicillins
GB1456627A (en) Pyridobenzodiazepinones
ES8200696A1 (es) Un procedimiento para la preparacion de nuevos compuestos amidicos de cefalosporina
MY103502A (en) Novel compounds
DE3267188D1 (en) Hydroxybenzylamino-aryl compounds, process for preparing and pharmaceutical compositions containing the same
DE2965701D1 (en) 1-imidazol-2-ylidene-3-thienyl-urea derivatives, processes therefor, and pharmaceutical compositions
GB1381210A (en) Azomethines of 4-amino-5-h-1,2,4-triazin-5-ones process for their production and their use as herbicides
GB1526793A (en) 7alpha-methoxycephalosporins
FR2361114A1 (fr) Procede de preparation d'analogues de cephalosporine a propriete antibacterienne et nouveaux produits ainsi obtenus
NO881644L (no) Fremgangsmaate for fremstilling av thiadiazolylacetamid cefem-derivater.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009