ES8201957A1 - Un procedimiento para producir un precursor de insulina - Google Patents

Un procedimiento para producir un precursor de insulina

Info

Publication number
ES8201957A1
ES8201957A1 ES500747A ES500747A ES8201957A1 ES 8201957 A1 ES8201957 A1 ES 8201957A1 ES 500747 A ES500747 A ES 500747A ES 500747 A ES500747 A ES 500747A ES 8201957 A1 ES8201957 A1 ES 8201957A1
Authority
ES
Spain
Prior art keywords
radical
insulin
formula
amino
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500747A
Other languages
English (en)
Other versions
ES500747A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26832281&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8201957(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES500747A0 publication Critical patent/ES500747A0/es
Publication of ES8201957A1 publication Critical patent/ES8201957A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN PRECURSOR DE INSULINA DE FORMULA (I), EN LA QUE R ES HIDROGENO, O UN RADICAL AMINOACIDO O PEPTIDO QUE TIENE AL MENOS DOS RESTOS AMINOACIDOS; Y ES -LIS-Z-; ES DONDE Z ES ALA, THR O SER; EL RADICAL ENTRE A1 Y A-21 ES UNA CADENA A DE INSULINA; EL RADICAL B-1 A B-30 ES UNA CADENA B DE INSULINA, Y X ES UN RADICAL UNIDO AL GRUPO AMINO A-1 Y AL EPSILON-AMINO-B-29 O CARBOXILO B-30. CONSISTE EN LA REACCIONDE UN S-SULFONATO DE FORMULA (II), EN LA QUE R, X E Y TIENEN EL MISMO SIGNIFICADO QUE ENLA FORMULA (I), CON UN MERCAPTANO EN UNA CONCENTRACION QUE PROPORCIONA DE 1 A 5 MITADES -SH POR CADA MITAD-SSO3, EN DISOLUCION ACUOSA EN UN PH ENTRE 7 Y 11,5.
ES500747A 1980-03-27 1981-03-26 Un procedimiento para producir un precursor de insulina Expired ES8201957A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13438980A 1980-03-27 1980-03-27
US21069680A 1980-11-28 1980-11-28

Publications (2)

Publication Number Publication Date
ES500747A0 ES500747A0 (es) 1982-01-16
ES8201957A1 true ES8201957A1 (es) 1982-01-16

Family

ID=26832281

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500747A Expired ES8201957A1 (es) 1980-03-27 1981-03-26 Un procedimiento para producir un precursor de insulina

Country Status (23)

Country Link
EP (1) EP0037255B2 (es)
KR (1) KR840000946B1 (es)
AR (1) AR224933A1 (es)
AU (1) AU540644B2 (es)
CA (1) CA1154435A (es)
DD (1) DD157612A5 (es)
DE (1) DE3161475D1 (es)
DK (1) DK149863C (es)
EG (1) EG15310A (es)
ES (1) ES8201957A1 (es)
FI (1) FI810917A7 (es)
GB (1) GB2073204B (es)
GR (1) GR73517B (es)
HU (1) HU185249B (es)
IE (1) IE51172B1 (es)
IL (1) IL62486A (es)
NO (1) NO151898C (es)
NZ (1) NZ196609A (es)
PL (1) PL127843B1 (es)
PT (1) PT72732B (es)
RO (1) RO81951B (es)
SU (1) SU1301319A3 (es)
YU (1) YU76881A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0090433A1 (en) * 1982-03-31 1983-10-05 Genetics Institute, Inc. Creation of DNA sequences encoding modified proinsulin precursors
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
DK0600372T3 (da) 1992-12-02 1997-08-11 Hoechst Ag Fremgangsmåde til fremstilling af proinsulin med korrekt forbundne cystinbroer.
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
US10745457B2 (en) 2015-09-02 2020-08-18 Merck Sharp & Dohme Corp. Process for obtaining insulin with correctly formed disulfide bonds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten

Also Published As

Publication number Publication date
PL230292A1 (es) 1981-11-27
AR224933A1 (es) 1982-01-29
PT72732A (en) 1981-04-01
DK136481A (da) 1981-09-28
ES500747A0 (es) 1982-01-16
NO151898C (no) 1985-06-26
CA1154435A (en) 1983-09-27
RO81951A (ro) 1984-02-21
GB2073204B (en) 1983-09-21
SU1301319A3 (ru) 1987-03-30
DD157612A5 (de) 1982-11-24
FI810917L (fi) 1981-09-28
FI810917A7 (fi) 1981-09-28
EP0037255B1 (en) 1983-11-23
PT72732B (en) 1982-03-23
EP0037255B2 (en) 1989-04-05
EP0037255A1 (en) 1981-10-07
DK149863B (da) 1986-10-13
EG15310A (en) 1985-12-31
IL62486A (en) 1984-12-31
DE3161475D1 (en) 1983-12-29
AU540644B2 (en) 1984-11-29
PL127843B1 (en) 1983-11-30
KR830005251A (ko) 1983-08-03
NO151898B (no) 1985-03-18
KR840000946B1 (ko) 1984-07-01
IE810679L (en) 1981-09-27
AU6871981A (en) 1981-10-01
RO81951B (ro) 1984-02-28
GR73517B (es) 1984-03-08
YU76881A (en) 1984-04-30
IL62486A0 (en) 1981-05-20
NZ196609A (en) 1984-02-03
NO811039L (no) 1981-09-28
IE51172B1 (en) 1986-10-29
GB2073204A (en) 1981-10-14
DK149863C (da) 1987-06-01
HU185249B (en) 1984-12-28

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