ES8205202A1 - Un procedimiento para preparar un compuesto de quinazolina - Google Patents

Un procedimiento para preparar un compuesto de quinazolina

Info

Publication number
ES8205202A1
ES8205202A1 ES497426A ES497426A ES8205202A1 ES 8205202 A1 ES8205202 A1 ES 8205202A1 ES 497426 A ES497426 A ES 497426A ES 497426 A ES497426 A ES 497426A ES 8205202 A1 ES8205202 A1 ES 8205202A1
Authority
ES
Spain
Prior art keywords
quinazoline derivatives
carboxy
chem
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497426A
Other languages
English (en)
Other versions
ES497426A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8205202A1 publication Critical patent/ES8205202A1/es
Publication of ES497426A0 publication Critical patent/ES497426A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO DE QUINAZOLINA, ASI COMO DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 Y R2 SON CARBOXI ESTERIFICADO Y A, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE ADICION EL COMPUESTO DE FORMULA (II) AL COMPUESTO DE FORMULA (III), EN LAS QUE R5 ES ALCOXI Y TODOS LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). SI UNO DE LOS GRUPOS R3 O R4 ES NITRO Y EL OTRO ES HIDROGENO, EL COMPUESTO OBTENIDO SE SOMETE A REDUCCION CATALITICA CON UN CATALIZADOR CONVENCIONAL PARA TRANSFORMAR EL GRUPO NITRO EN AMINO. LA REACCION DE ADICION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE Y EN UN AMPLIO MARGEN DE TEMPERATURAS.
ES497426A 1979-12-03 1980-12-03 Un procedimiento para preparar un compuesto de quinazolina Granted ES497426A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7941607 1979-12-03
GB8031965 1980-10-03

Publications (2)

Publication Number Publication Date
ES8205202A1 true ES8205202A1 (es) 1982-06-01
ES497426A0 ES497426A0 (es) 1982-06-01

Family

ID=26273769

Family Applications (4)

Application Number Title Priority Date Filing Date
ES497426A Granted ES497426A0 (es) 1979-12-03 1980-12-03 Un procedimiento para preparar un compuesto de quinazolina
ES507996A Expired ES8207540A1 (es) 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de pirimidoquinazolina.
ES507994A Expired ES8301234A1 (es) 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de quinazolina.
ES507995A Granted ES507995A0 (es) 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de pirimidoquinazolina.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES507996A Expired ES8207540A1 (es) 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de pirimidoquinazolina.
ES507994A Expired ES8301234A1 (es) 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de quinazolina.
ES507995A Granted ES507995A0 (es) 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de pirimidoquinazolina.

Country Status (10)

Country Link
US (2) US4377580A (es)
EP (1) EP0030156B1 (es)
JP (1) JPH0651686B2 (es)
AT (1) ATE6778T1 (es)
AU (1) AU541811B2 (es)
DE (1) DE3067201D1 (es)
DK (1) DK513980A (es)
ES (4) ES497426A0 (es)
GR (1) GR71637B (es)
IE (1) IE51802B1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3046366A1 (de) * 1980-12-09 1982-07-08 Bayer Ag, 5090 Leverkusen Tricyclische cytosinderivate zur verwendung in arzneimitteln und verfahren zu ihrer herstellung
JPS608274A (ja) * 1983-06-27 1985-01-17 Fujisawa Pharmaceut Co Ltd 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤
NO162019C (no) * 1983-11-23 1989-10-25 Fujisawa Pharmaceutical Co Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
CN101137412B (zh) 2005-01-13 2012-11-07 布里斯托尔-迈尔斯·斯奎布公司 用作凝血因子XIa抑制剂的取代的二芳基化合物
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US8633186B2 (en) * 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
AU2013202912B2 (en) * 2007-06-08 2016-10-27 Firmenich Incorporated Modulation of chemosensory receptors and ligands associated therewith
MX2011001155A (es) 2008-07-31 2011-07-29 Senomyx Inc Composiciones que comprenden mejoradores del dulzor, y métodos para prepararlas.
EP3085699B1 (en) 2008-07-31 2022-03-02 Firmenich Incorporated Processes for making sweet taste enhancers
CN103153096B (zh) 2010-08-12 2016-08-03 赛诺米克斯公司 提高甜味增强剂的稳定性的方法和包含稳定的甜味增强剂的组合物
JP6231085B2 (ja) * 2012-05-31 2017-11-15 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト アミノキナゾリン誘導体及びピリドピリミジン誘導体
AU2013299859B2 (en) 2012-08-06 2017-06-15 Firmenich Incorporated Sweet flavor modifier
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
WO2020033420A1 (en) 2018-08-07 2020-02-13 Firmenich Incorporated 5-substituted 4-amino-1h-benzo[c][1,2,6]thiadiazine 2,2-dioxides and formulations and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1086666A (en) * 1966-09-12 1967-10-11 Wander Ag Dr A Novel 6-p-tolyl-2,3,6,7-tetrahydro-4h-pyrimido-[1,2-c] quinazoline
US3594379A (en) * 1968-09-16 1971-07-20 Sandoz Ag 2,3-dihydroimidazo(1,2-c)quinazolines
BE759842R (fr) 1969-12-05 1971-06-03 Sandoz Sa Nouveaux derives de la 4-amino-quinazoline, leur preparation etmedicaments contenant ces
CA986932A (en) * 1970-08-27 1976-04-06 Shigeho Inaba Process for preparing quinazoline derivatives
US4167569A (en) * 1976-12-09 1979-09-11 Imperial Chemical Industries Limited Pyrimido[1,2-a ]benzimidazole derivatives
US4105766A (en) * 1977-08-19 1978-08-08 Sterling Drug Inc. 4,5-Dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylic acid derivatives
US4192944A (en) * 1978-04-03 1980-03-11 Bristol-Myers Company Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents

Also Published As

Publication number Publication date
ATE6778T1 (de) 1984-04-15
ES507994A0 (es) 1982-11-16
EP0030156A1 (en) 1981-06-10
AU541811B2 (en) 1985-01-24
ES507996A0 (es) 1982-10-01
IE802421L (en) 1981-06-03
DK513980A (da) 1981-06-04
ES8207539A1 (es) 1982-10-01
US4377580A (en) 1983-03-22
US4543356A (en) 1985-09-24
AU6473380A (en) 1981-06-11
IE51802B1 (en) 1987-04-01
ES8301234A1 (es) 1982-11-16
JPH0651686B2 (ja) 1994-07-06
ES8207540A1 (es) 1982-10-01
EP0030156B1 (en) 1984-03-21
JPH05294946A (ja) 1993-11-09
DE3067201D1 (en) 1984-04-26
ES507995A0 (es) 1982-10-01
GR71637B (es) 1983-06-20
ES497426A0 (es) 1982-06-01

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