ES8205406A1 - Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina. - Google Patents

Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina.

Info

Publication number
ES8205406A1
ES8205406A1 ES500055A ES500055A ES8205406A1 ES 8205406 A1 ES8205406 A1 ES 8205406A1 ES 500055 A ES500055 A ES 500055A ES 500055 A ES500055 A ES 500055A ES 8205406 A1 ES8205406 A1 ES 8205406A1
Authority
ES
Spain
Prior art keywords
formula
picropodophyllin
intermediates
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500055A
Other languages
English (en)
Other versions
ES500055A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Rochester
Original Assignee
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Rochester filed Critical University of Rochester
Publication of ES8205406A1 publication Critical patent/ES8205406A1/es
Publication of ES500055A0 publication Critical patent/ES500055A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS INTERMEDIOS, EMPLEADOS EN LA SINTESIS DE PICROPODOFILINA, DE FORMULA (I), EN LA QUE Z1 Y Z2 SON GRUPOS ACEPTORES DE ELECTRONES NO REACTIVOS; R1, R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADIALES, Y "N" VALE 0 O 1. CONSISTE EN LA REACCION DE UN CONPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE UN ALCOHIL LITIO, FORMULAS EN LA QUE "N", Z1, Z2 Y R1-R4 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), Y X E Y PUEDEN SER CLORO, BROMO O YODO, E Y, ADEMAS, UN GRUPO ELIMINABLE. LA REACCION SE CALIENTA LENTAMENTE HASTA UN TEMPERATURA ENTRE 0 Y 120 C.
ES500055A 1980-03-05 1981-03-04 Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina. Granted ES500055A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/127,436 US4294763A (en) 1980-03-05 1980-03-05 Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof

Publications (2)

Publication Number Publication Date
ES8205406A1 true ES8205406A1 (es) 1982-06-01
ES500055A0 ES500055A0 (es) 1982-06-01

Family

ID=22430103

Family Applications (3)

Application Number Title Priority Date Filing Date
ES500051A Granted ES500051A0 (es) 1980-03-05 1981-03-04 Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina.
ES500055A Granted ES500055A0 (es) 1980-03-05 1981-03-04 Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina.
ES500056A Granted ES500056A0 (es) 1980-03-05 1981-03-04 Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES500051A Granted ES500051A0 (es) 1980-03-05 1981-03-04 Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES500056A Granted ES500056A0 (es) 1980-03-05 1981-03-04 Un procedimiento de preparacion de compuestos intermedios para la produccion de picropodofilina.

Country Status (8)

Country Link
US (1) US4294763A (es)
JP (2) JPS572229A (es)
CA (1) CA1181083A (es)
CH (2) CH655303A5 (es)
DE (2) DE3153681C2 (es)
ES (3) ES500051A0 (es)
GB (2) GB2070609B (es)
IT (1) IT1212502B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708964A (en) * 1984-02-09 1987-11-24 Chemex Pharmaceuticals Lipoxygenase inhibitors
US4866189A (en) * 1985-04-12 1989-09-12 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4795819A (en) * 1985-04-12 1989-01-03 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5106996A (en) * 1985-12-05 1992-04-21 Bristol-Myers Company Process for the preparation of podophyllotoxin
US5013851A (en) * 1985-12-05 1991-05-07 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
WO2009100349A1 (en) * 2008-02-09 2009-08-13 The Trustees Of Columbia University In The City Of New York Analogues of (-)-picropodophyllin, synthesis and uses thereof
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1088621A (en) 1963-12-12 1967-10-25 Sandoz Ltd Improvements in or relating to podophyllin derivatives
NL6613143A (es) * 1965-09-21 1967-03-22
US4122092A (en) * 1977-08-25 1978-10-24 University Of Rochester Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone

Also Published As

Publication number Publication date
IT1212502B (it) 1989-11-22
CH657363A5 (de) 1986-08-29
ES8205407A1 (es) 1982-06-01
JPS572229A (en) 1982-01-07
ES8205408A1 (es) 1982-06-01
GB2116182A (en) 1983-09-21
JPH01199929A (ja) 1989-08-11
GB2070609B (en) 1984-08-08
GB2116182B (en) 1984-10-31
DE3153681C2 (es) 1992-07-09
US4294763A (en) 1981-10-13
JPH0148272B2 (es) 1989-10-18
DE3106674C2 (es) 1992-06-11
IT8120148A0 (it) 1981-03-05
CH655303A5 (de) 1986-04-15
DE3106674A1 (de) 1981-12-17
ES500056A0 (es) 1982-06-01
ES500055A0 (es) 1982-06-01
GB2070609A (en) 1981-09-09
ES500051A0 (es) 1982-06-01
CA1181083A (en) 1985-01-15
GB8308455D0 (en) 1983-05-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203