ES8206548A1 - Procedimiento para la preparacion de nuevos analogos utiles de lincomicina y clindamicina. - Google Patents
Procedimiento para la preparacion de nuevos analogos utiles de lincomicina y clindamicina.Info
- Publication number
- ES8206548A1 ES8206548A1 ES507346A ES507346A ES8206548A1 ES 8206548 A1 ES8206548 A1 ES 8206548A1 ES 507346 A ES507346 A ES 507346A ES 507346 A ES507346 A ES 507346A ES 8206548 A1 ES8206548 A1 ES 8206548A1
- Authority
- ES
- Spain
- Prior art keywords
- lincomycin
- clindamycin
- analogue
- reaction
- lincosamidina
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960002227 clindamycin Drugs 0.000 title 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 title 1
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical class CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229910003446 platinum oxide Inorganic materials 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
- C07H15/16—Lincomycin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCIO DE ANALOGOS DE LINCOMICINA Y CLINDAMICINA. CONSISTE EN LA REACCION DE REDUCCION DE UN COMPUESTO DE FORMULA (I), EN LA QUEZ X ES 7(S)-CLOROMETIL-1-TIO-A-LINCOSAMIDINA. LA REACCION SE LEVA A CABO POR TRATAMIENTO CON HIDROGENO EN UN HIDROGENADOR PARR A UNAS3 ATMOSFERAS, EN PRESENCIA DE CATALIZADOR DE OXIDO DE PLATINO. EL PRODUCTO SE SEPARA POR FILTRACION Y SE PURIFICA POR METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS CONO ANTIBIOTICOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9665279A | 1979-11-23 | 1979-11-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8206548A1 true ES8206548A1 (es) | 1982-08-16 |
| ES507346A0 ES507346A0 (es) | 1982-08-16 |
Family
ID=22258400
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507345A Granted ES507345A0 (es) | 1979-11-23 | 1981-11-20 | Procedimiento para la preparacion de nuevos analogos utiles de lincomicina y clindamicina. |
| ES507346A Granted ES507346A0 (es) | 1979-11-23 | 1981-11-20 | Procedimiento para la preparacion de nuevos analogos utiles de lincomicina y clindamicina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507345A Granted ES507345A0 (es) | 1979-11-23 | 1981-11-20 | Procedimiento para la preparacion de nuevos analogos utiles de lincomicina y clindamicina. |
Country Status (4)
| Country | Link |
|---|---|
| JP (2) | JPS5687597A (es) |
| BE (1) | BE886301A (es) |
| ES (2) | ES507345A0 (es) |
| ZA (1) | ZA806438B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0411537A (pt) * | 2003-06-17 | 2006-08-01 | Vicuron Pharm Inc | derivados de lincomicina que possuem atividade antibacteriana |
-
1980
- 1980-10-20 ZA ZA00806438A patent/ZA806438B/xx unknown
- 1980-11-20 JP JP16272380A patent/JPS5687597A/ja active Granted
- 1980-11-21 BE BE0/202901A patent/BE886301A/fr not_active IP Right Cessation
-
1981
- 1981-11-20 ES ES507345A patent/ES507345A0/es active Granted
- 1981-11-20 ES ES507346A patent/ES507346A0/es active Granted
-
1988
- 1988-02-09 JP JP63026734A patent/JPS63225392A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| BE886301A (fr) | 1981-05-21 |
| JPS63225392A (ja) | 1988-09-20 |
| JPS5687597A (en) | 1981-07-16 |
| JPS6338037B2 (es) | 1988-07-28 |
| JPH0141157B2 (es) | 1989-09-04 |
| ZA806438B (en) | 1981-10-28 |
| ES507346A0 (es) | 1982-08-16 |
| ES8206547A1 (es) | 1982-09-01 |
| ES507345A0 (es) | 1982-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted |