ES8301212A1 - Procedimiento para la preparacion de derivados de prostaciclina. - Google Patents

Procedimiento para la preparacion de derivados de prostaciclina.

Info

Publication number
ES8301212A1
ES8301212A1 ES509176A ES509176A ES8301212A1 ES 8301212 A1 ES8301212 A1 ES 8301212A1 ES 509176 A ES509176 A ES 509176A ES 509176 A ES509176 A ES 509176A ES 8301212 A1 ES8301212 A1 ES 8301212A1
Authority
ES
Spain
Prior art keywords
prostacyclins
imino
hetero
preparation
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509176A
Other languages
English (en)
Other versions
ES509176A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8301212A1 publication Critical patent/ES8301212A1/es
Publication of ES509176A0 publication Critical patent/ES509176A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PROSTACICLINA DE FORMULA (I), EN LA QUE X ES NH; Y R , R , R , Y Y Z PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA Z<024>Y<024>NH , EN LAS QUE R ES ALCOHILO C <003> Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO CON CALENTAMIENTO EN UN ALCANOL INFERIOR COMO METANOL O ETANOL, O EN DISOLVENTES INERTES TALES COMO DIOXANO O ACETONA. >ESTOS COMPUESTOS TIENEN APLICACIONES PARA EL TRATAMIENTO DE LA TROMBOSIS Y DE INFARTOS.
ES509176A 1980-02-23 1982-01-29 Procedimiento para la preparacion de derivados de prostaciclina. Granted ES509176A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803006865 DE3006865A1 (de) 1980-02-23 1980-02-23 Hetero-imino-prostacycline

Publications (2)

Publication Number Publication Date
ES8301212A1 true ES8301212A1 (es) 1982-11-16
ES509176A0 ES509176A0 (es) 1982-11-16

Family

ID=6095414

Family Applications (2)

Application Number Title Priority Date Filing Date
ES499484A Granted ES499484A0 (es) 1980-02-23 1981-02-17 Procedimiento para la preparacion de derivados de prostaci- clina
ES509176A Granted ES509176A0 (es) 1980-02-23 1982-01-29 Procedimiento para la preparacion de derivados de prostaciclina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES499484A Granted ES499484A0 (es) 1980-02-23 1981-02-17 Procedimiento para la preparacion de derivados de prostaci- clina

Country Status (17)

Country Link
US (1) US4371542A (es)
EP (1) EP0034778B1 (es)
JP (1) JPS56133265A (es)
AT (1) ATE7225T1 (es)
AU (1) AU545358B2 (es)
CA (1) CA1198106A (es)
DE (2) DE3006865A1 (es)
DK (1) DK157852C (es)
ES (2) ES499484A0 (es)
FI (1) FI810509L (es)
HU (1) HU187318B (es)
IE (1) IE50957B1 (es)
IL (1) IL62197A (es)
MX (1) MX6834E (es)
NZ (1) NZ196316A (es)
PH (1) PH21973A (es)
ZA (1) ZA811146B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2946756A1 (de) * 1979-11-20 1981-05-27 Hoechst Ag, 6000 Frankfurt Stickstoff-haltige prostaglandin/prostacyclin-synthone und verfahren zu ihrer herstellung
DE3100083A1 (de) * 1981-01-03 1982-08-05 Hoechst Ag, 6000 Frankfurt "11-desoxy-hetero-imino-prostacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel"
DE3272423D1 (en) * 1981-04-13 1986-09-11 Schering Ag Prostaglandins and prostacyclins, their preparations and pharmaceutical applications
DE3117979A1 (de) * 1981-05-07 1983-01-20 Hoechst Ag, 6000 Frankfurt Neue(delta)1-pyrrolin-thiolactimaether und verfahren zu ihrer herstellung
JPS6028943A (ja) * 1983-07-26 1985-02-14 Sankyo Co Ltd カルバサイクリン類縁体
JPS60181041A (ja) * 1984-02-29 1985-09-14 Sankyo Co Ltd カルバサイクリン誘導体
JPS6130554A (ja) * 1984-07-23 1986-02-12 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物のある特定の立体配置を有する異性体及びそれらを有効成分として含有する治療剤
US5221689A (en) * 1984-07-23 1993-06-22 Ono Pharmaceutical Co., Ltd. Prostaglandin analogues, processes for their preparation and pharmaceutical compositions containing them
CA1284642C (en) * 1986-03-31 1991-06-04 Hikozo Iwakura Prostacyclin (pgi ) analogues
KR0158870B1 (ko) * 1988-06-17 1998-12-01 마틴 에이. 로쓰블랫 폐순환 승압의 치료, 예방 또는 진단용 조성물
EP2484655A1 (en) * 2011-02-04 2012-08-08 Vironova AB A thionation process and a thionating agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097489A (en) * 1977-06-17 1978-06-27 The Upjohn Company 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds
JPS54125653A (en) * 1978-03-18 1979-09-29 Ono Pharmaceut Co Ltd Prostaglandin i2 analog, its preparation, and drug composition comprising it as active constituent

Also Published As

Publication number Publication date
CA1198106A (en) 1985-12-17
FI810509A7 (fi) 1981-08-24
MX6834E (es) 1986-08-15
DE3006865A1 (de) 1981-09-10
EP0034778B1 (de) 1984-04-25
DE3163263D1 (en) 1984-05-30
JPH032860B2 (es) 1991-01-17
IE810349L (en) 1981-08-23
HU187318B (en) 1985-12-28
ATE7225T1 (de) 1984-05-15
IL62197A (en) 1986-09-30
ES509176A0 (es) 1982-11-16
IE50957B1 (en) 1986-08-20
DK157852B (da) 1990-02-26
FI810509L (fi) 1981-08-24
DK78181A (da) 1981-08-24
EP0034778A1 (de) 1981-09-02
JPS56133265A (en) 1981-10-19
ES8206473A1 (es) 1982-08-16
ZA811146B (en) 1982-03-31
IL62197A0 (en) 1981-03-31
US4371542A (en) 1983-02-01
AU545358B2 (en) 1985-07-11
ES499484A0 (es) 1982-08-16
NZ196316A (en) 1984-08-24
AU6750981A (en) 1981-09-03
DK157852C (da) 1990-07-30
PH21973A (en) 1988-05-02

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