ES8301502A1 - Procedimiento para la preparacion microbiologica de un polipeptido que contiene total o parcialmente la secuencia de a- minoacidos del interferon de leucocitos humanos. - Google Patents

Procedimiento para la preparacion microbiologica de un polipeptido que contiene total o parcialmente la secuencia de a- minoacidos del interferon de leucocitos humanos.

Info

Publication number
ES8301502A1
ES8301502A1 ES499259A ES499259A ES8301502A1 ES 8301502 A1 ES8301502 A1 ES 8301502A1 ES 499259 A ES499259 A ES 499259A ES 499259 A ES499259 A ES 499259A ES 8301502 A1 ES8301502 A1 ES 8301502A1
Authority
ES
Spain
Prior art keywords
interferon
human
production
cdna
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499259A
Other languages
English (en)
Other versions
ES499259A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES499259A0 publication Critical patent/ES499259A0/es
Publication of ES8301502A1 publication Critical patent/ES8301502A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION MICROBIOLOGICA DE UN POLIPEPTIDO QUE CONTIENE TOTAL O PARCIALMENTE LA SECUENCIA DE AMINOACIDOS DEL INTERFERON DE LEUCOCITOS HUMANOS. COMPRENDE LAS SIGUIENTES FASES: PRIMERA, SE ACTIVAN LEUCOCITOS PRODUCTORES DE INTERFERON PARA FORMAR ACIDO RIBONUCLEICO MENSAJERO DE INTERFERON; SEGUNDA, SE SEPARA Y SE PURIFICA EL ACIDO RIBONUCLEICO MENSAJERO FORMADO; TERCERA, SE PREPARA CON AYUDA DE LA ENZIMA TRANSCRIPTASA INVERSA UNA DOBLE HEBRA DE ACIDO RIBONUCLEICO-ACIDO DESOXI DIBONUCLEICO; CUARTA, SE RETIRA EL ACIDO RIBONUCLEICO DE LA DOBLE HEBRA MEDIANTE HIDROLISIS; QUINTA, SE COMPLETA LA HEBRA DE ACIDO DESOXI RIBONUCLEICO Y SE INCORPORA EN UN PLASMIDO; SEXTA, SE HACE UN CULTIVO DE MICROORGANISMOS QUE CONTIENEN LA INFORMACION GENETICA EN EL PLASMIDO Y SE EXTRAE DE ELLOS EL POLIPEPTIDO FORMADO.
ES499259A 1980-02-16 1981-02-10 Procedimiento para la preparacion microbiologica de un polipeptido que contiene total o parcialmente la secuencia de a- minoacidos del interferon de leucocitos humanos. Expired ES8301502A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803005897 DE3005897A1 (de) 1980-02-16 1980-02-16 Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus

Publications (2)

Publication Number Publication Date
ES499259A0 ES499259A0 (es) 1982-12-01
ES8301502A1 true ES8301502A1 (es) 1982-12-01

Family

ID=6094832

Family Applications (3)

Application Number Title Priority Date Filing Date
ES499261A Granted ES499261A0 (es) 1980-02-16 1981-02-10 Procedimiento para la preparacion de un plasmido que codifica para la secuencia de aminoacidos del interferon de leuco- citos humanos.
ES499259A Expired ES8301502A1 (es) 1980-02-16 1981-02-10 Procedimiento para la preparacion microbiologica de un polipeptido que contiene total o parcialmente la secuencia de a- minoacidos del interferon de leucocitos humanos.
ES499262A Expired ES8205428A1 (es) 1980-02-16 1981-02-10 Procedimiento para la obtencion de un microorganismo que forma un polipetido con la secuencia de aminoacidos del inter- feron de leucocitos humanos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES499261A Granted ES499261A0 (es) 1980-02-16 1981-02-10 Procedimiento para la preparacion de un plasmido que codifica para la secuencia de aminoacidos del interferon de leuco- citos humanos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES499262A Expired ES8205428A1 (es) 1980-02-16 1981-02-10 Procedimiento para la obtencion de un microorganismo que forma un polipetido con la secuencia de aminoacidos del inter- feron de leucocitos humanos.

Country Status (13)

Country Link
EP (1) EP0034307B1 (es)
JP (1) JPS56158793A (es)
AT (1) ATE26463T1 (es)
AU (1) AU6728881A (es)
BE (1) BE887529A (es)
DE (2) DE3005897A1 (es)
ES (3) ES499261A0 (es)
FR (1) FR2478124A1 (es)
GB (1) GB2071108A (es)
IT (1) IT1141977B (es)
NL (1) NL8100718A (es)
SE (1) SE8101005L (es)
ZA (1) ZA81975B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0041313B1 (en) 1980-04-03 1990-09-12 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing human fibroblast interferon
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
CH651308A5 (de) * 1980-07-01 1985-09-13 Hoffmann La Roche Interferone und deren herstellung.
GB2108510B (en) * 1981-10-03 1984-12-12 Ciba Geigy Ag Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof
US5582824A (en) * 1981-10-19 1996-12-10 Genentech, Inc. Recombinant DES-CYS-TYR-CYS human immune interferon
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
JPS58116498A (ja) * 1981-12-28 1983-07-11 Takeda Chem Ind Ltd Ｉｌ‐２をコードする新規伝令ｒｎａの製造法
US4450103A (en) * 1982-03-01 1984-05-22 Cetus Corporation Process for recovering human IFN-β from a transformed microorganism
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
DE3220116A1 (de) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
ZA846554B (en) * 1983-09-20 1985-04-24 Hoffmann La Roche Immune interferon and method for its purification
US4855238A (en) 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
MX9203641A (es) * 1983-12-16 1992-07-01 Genentech Inc Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion.
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
WO1998006431A2 (en) * 1996-08-16 1998-02-19 Osther Kurt B Method for treating diabetes
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
SG161247A1 (en) 2005-04-11 2010-05-27 Savient Pharmaceuticals Inc Variant forms of urate oxidase and use thereof
JP5033177B2 (ja) 2006-04-12 2012-09-26 サビエント ファーマセウティカルズ インク． 陽イオン界面活性剤によるタンパク質の精製
EP2207890A4 (en) 2007-10-05 2010-12-15 Barofold Inc HIGH PRESSURE PROCESSING OF AGGREGATED INTERFERONS
US9377454B2 (en) 2009-06-25 2016-06-28 Crealta Pharmaceuticals Llc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN116637177A (zh) 2016-11-11 2023-08-25 好利恩治疗美国公司 泼尼松和尿酸酶分子的组合疗法及其用途
WO2020160325A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
AU538665B2 (en) * 1979-10-30 1984-08-23 Juridical Foundation, Japanese Foundation For Cancer Research Human interferon dna
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
ES8308534A1 (es) * 1980-01-08 1983-09-01 Biogen Nv Un metodo de producir un polipeptido que exhibe actividad inmunologica o biologica del interferon de leucocitos humanos.
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein

Also Published As

Publication number Publication date
ATE26463T1 (de) 1987-04-15
NL8100718A (nl) 1981-09-16
FR2478124A1 (fr) 1981-09-18
EP0034307B1 (de) 1987-04-08
BE887529A (fr) 1981-08-17
ZA81975B (en) 1982-03-31
IT1141977B (it) 1986-10-08
IT8119760A0 (it) 1981-02-13
ES8205431A1 (es) 1982-06-01
EP0034307A2 (de) 1981-08-26
DE3176088D1 (en) 1987-05-14
AU6728881A (en) 1981-08-27
ES499262A0 (es) 1982-06-01
ES499259A0 (es) 1982-12-01
EP0034307A3 (en) 1981-11-18
DE3005897A1 (de) 1981-09-03
JPS56158793A (en) 1981-12-07
GB2071108A (en) 1981-09-16
SE8101005L (sv) 1981-08-17
ES499261A0 (es) 1982-06-01
ES8205428A1 (es) 1982-06-01

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