ES8308534A1 - Un metodo de producir un polipeptido que exhibe actividad inmunologica o biologica del interferon de leucocitos humanos. - Google Patents

Un metodo de producir un polipeptido que exhibe actividad inmunologica o biologica del interferon de leucocitos humanos.

Info

Publication number
ES8308534A1
ES8308534A1 ES498343A ES498343A ES8308534A1 ES 8308534 A1 ES8308534 A1 ES 8308534A1 ES 498343 A ES498343 A ES 498343A ES 498343 A ES498343 A ES 498343A ES 8308534 A1 ES8308534 A1 ES 8308534A1
Authority
ES
Spain
Prior art keywords
polypeptides
human interferon
dna sequences
recombinant dna
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498343A
Other languages
English (en)
Other versions
ES498343A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Original Assignee
Biogen NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27224760&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8308534(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen NV filed Critical Biogen NV
Publication of ES498343A0 publication Critical patent/ES498343A0/es
Publication of ES8308534A1 publication Critical patent/ES8308534A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/839—Bacillus subtilis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UN METODO DE PRODUCIR UN POLIPEPTIDO QUE EXHIBE ACTIVIDAD INMUNOLOGICA O BIOLOGICA DEL INTERFERON DE LEUCOCITOS HUMANOS. SE EFECTUAN LAS SIGUIENTES OPERACIONES: 1 ) CULTIVAR UN HUESPED TRANSFORMADO QUE SE CARACTERIZA POR UNA SECUENCIA DE ADN QUE CODIFICA EL POLIPEPTIDO, UNIDA OPERATIVAMENTE A UNA SECUENCIA DE CONTROL DE EXPRESION. 2 ) COSECHAR EL POLIPEPTIDO, SELECCIONANDOSE LA SECUENCIA DE ADN DEL GRUPO CONSTITUIDO POR LAS INSERCIONES DE ADN DE Z-PBR322(PST)/HCIF-4C, Z-PBR322(PST)/HCIF-2H, Z-PBR322(PST)/HCIF- -SN35, Z-PBR322(PST)/HCIF-SN42, Z-PKT287(PST)/HCIF-2H-AH6, SECUENCIAS DE ADN QUE SE HIBRIDAN A CUALQUIERA DE LAS INSERCIONES DE ADN PRECEDENTES Y QUE CODIFICAN UN POLIPEPTIDO DEL TIPO IFN-~C, Y SECUENCIAS DE ADN QUE CODIFICAN POR EXPRESION UN POLIPEPTIDO CODIFICADO POR EXPRESION POR CUALQUIERA DE LAS SECUENCIAS E INSERCIONES DE ADN PRECEDENTES.
ES498343A 1980-01-08 1981-01-07 Un metodo de producir un polipeptido que exhibe actividad inmunologica o biologica del interferon de leucocitos humanos. Expired ES8308534A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP80300079 1980-01-08
EP80301100 1980-04-03
GB8031737 1980-10-02

Publications (2)

Publication Number Publication Date
ES498343A0 ES498343A0 (es) 1983-09-01
ES8308534A1 true ES8308534A1 (es) 1983-09-01

Family

ID=27224760

Family Applications (2)

Application Number Title Priority Date Filing Date
ES498343A Expired ES8308534A1 (es) 1980-01-08 1981-01-07 Un metodo de producir un polipeptido que exhibe actividad inmunologica o biologica del interferon de leucocitos humanos.
ES509222A Granted ES509222A0 (es) 1980-01-08 1982-02-01 Un metodo para producir una molecula de adn recombinante caracterizada por una secuencia de adn codificada de un coni- peptido semejante al, interferon humano.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES509222A Granted ES509222A0 (es) 1980-01-08 1982-02-01 Un metodo para producir una molecula de adn recombinante caracterizada por una secuencia de adn codificada de un coni- peptido semejante al, interferon humano.

Country Status (22)

Country Link
EP (1) EP0032134B2 (es)
JP (1) JP2501889B2 (es)
AU (1) AU553400B2 (es)
CA (1) CA1341567C (es)
CY (1) CY1346A (es)
DD (2) DD203071A5 (es)
DE (1) DE3165463D1 (es)
DK (2) DK170236B1 (es)
ES (2) ES8308534A1 (es)
FI (1) FI86558C (es)
GR (1) GR73557B (es)
HU (1) HU194305B (es)
IE (1) IE54096B1 (es)
MY (1) MY8700559A (es)
NO (2) NO164037C (es)
NZ (1) NZ195980A (es)
OA (1) OA06717A (es)
PH (1) PH21848A (es)
PL (1) PL148434B1 (es)
PT (1) PT72322B (es)
SG (1) SG77286G (es)
YU (1) YU45533B (es)

Families Citing this family (66)

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FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
FI88175C (fi) 1980-04-03 1993-04-13 Biogen Inc Rekombinant-dna-molekyler och foerfaranden foer framstaellning av polypeptider liknande humant -interferon
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
CH657141A5 (de) * 1980-07-01 1986-08-15 Hoffmann La Roche Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen.
ES8302778A1 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
DE3280127D1 (de) * 1981-03-27 1990-04-12 Ici Plc Genetisch modifizierte mikroorganismen.
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
GB2108510B (en) * 1981-10-03 1984-12-12 Ciba Geigy Ag Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
DE3220116A1 (de) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
GB8315980D0 (en) * 1983-06-10 1983-07-13 Biogen Nv Producing hybrid dna sequences
US4892743A (en) * 1983-12-21 1990-01-09 Schering Corporation Novel hybrid interferon species
EP0146903A3 (en) * 1983-12-19 1987-07-22 Schering Corporation Production of a vector encoding a novel hybrid interferon species
FR2560212B1 (fr) * 1984-02-24 1989-12-29 Unicet Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps
DE3574145D1 (en) * 1984-08-27 1989-12-14 Genentech Inc Novel, distinct family of human leukocyte interferons, compositions containing them, methods for their production, and dna and transfected hosts therefor
US5231176A (en) * 1984-08-27 1993-07-27 Genentech, Inc. Distinct family DNA encoding of human leukocyte interferons
IL76360A0 (en) * 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
EP0194006B1 (en) * 1985-02-01 1992-04-29 Imperial Chemical Industries Plc Analogous interferon polypeptides, process for their preparation and pharmaceutical compositions containing them
SE8502430L (sv) * 1985-05-15 1986-11-16 Kabivitrum Ab En cdna-molekyl som kodar for expressionen av en polypeptid av typen interferon alfa, en bakteriell eller celluler verd transformerad med en sadan molekyl och en polypeptid som uppvisar interferonaktivetet framstelld me
EP0205404B1 (en) * 1985-06-11 1992-07-15 Ciba-Geigy Ag Hybrid interferons
EP0208491B1 (en) * 1985-07-03 1993-08-25 Genencor International, Inc. Hybrid polypeptides and process for their preparation
US4846782A (en) * 1986-03-14 1989-07-11 Schering Corporation Treatment of cancer with interferon and radiotherapy
DE3751409T2 (de) 1986-04-15 1996-01-25 Ciba Geigy Ag Monoklonale Antikörper gegen Interferon-induziertes humanes Protein in gereignigter Form, und diese Antikörper enthaltende Testsätze.
US5028422A (en) * 1986-05-27 1991-07-02 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
US4851220A (en) * 1986-11-26 1989-07-25 Schering Corporation Stable oleaginous gel
US5190751A (en) * 1987-01-20 1993-03-02 Schering Corporation Treatment of certain leukemias with a combination of gamma interferon and alpha interferon
US4853218A (en) * 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
US4871538A (en) * 1987-07-13 1989-10-03 Schering Corporation Insoluble copper-alpha interferon complex
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US5256410A (en) * 1988-12-01 1993-10-26 Schering Corporation Treatment of squamous cell carcinoma intralesionally with recombinant human alpha interferon
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
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US6927040B2 (en) * 2000-06-30 2005-08-09 Zymogenetics, Inc. Interferon-like protein Zcyto21
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FR2824333B1 (fr) 2001-05-03 2003-08-08 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 5
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US8273561B2 (en) 2007-10-05 2012-09-25 Nuron Biotech, Inc. High pressure treatment of aggregated interferons
US20110257368A1 (en) 2008-12-23 2011-10-20 Schering Corporation Purification of recombinantly produced interferon
WO2019226050A2 (en) * 2018-05-24 2019-11-28 Wageningen Universiteit Novel viral anti-infective reagents

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AT373279B (de) * 1977-11-08 1984-01-10 Genentech Inc Verfahren zur herstellung eines rekombinationsclonbildungstraegers
AU538665B2 (en) * 1979-10-30 1984-08-23 Juridical Foundation, Japanese Foundation For Cancer Research Human interferon dna

Also Published As

Publication number Publication date
SG77286G (en) 1987-02-27
EP0032134A2 (en) 1981-07-15
DK61595A (da) 1995-05-31
JP2501889B2 (ja) 1996-05-29
DD203071A5 (de) 1983-10-12
OA06717A (fr) 1982-06-30
JPH02131431A (ja) 1990-05-21
DK5681A (da) 1981-07-09
FI86558B (fi) 1992-05-29
IE810025L (en) 1981-07-08
AU553400B2 (en) 1986-07-17
NO164037B (no) 1990-05-14
PL229123A1 (en) 1983-07-18
GR73557B (es) 1984-03-15
NO850733L (no) 1981-07-09
AU6605781A (en) 1981-07-30
PH21848A (en) 1988-03-17
DE3165463D1 (en) 1984-09-20
PT72322A (en) 1981-03-01
FI810030L (fi) 1981-07-09
HU194305B (en) 1988-01-28
EP0032134A3 (en) 1981-08-26
EP0032134B2 (en) 1993-10-13
ES498343A0 (es) 1983-09-01
YU45533B (en) 1992-05-28
YU2681A (en) 1983-12-31
PL148434B1 (en) 1989-10-31
MY8700559A (en) 1987-12-31
DK170236B1 (da) 1995-07-10
IE54096B1 (en) 1989-06-21
DD159782A5 (de) 1983-04-06
NO164037C (no) 1990-08-22
PT72322B (en) 1982-09-23
FI86558C (fi) 1992-09-10
ES8400770A1 (es) 1983-11-01
CY1346A (en) 1987-01-16
ES509222A0 (es) 1983-11-01
EP0032134B1 (en) 1984-08-15
NZ195980A (en) 1984-10-19
CA1341567C (en) 2008-02-19
NO810041L (no) 1981-07-09

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