ES8301626A1 - Un procedimiento mejorado para producir un preparado antimicrobiano de d-7(&-(4-hidroxi-6-metilnicotinamido)-4-hidroxi- fenilacetamido)-3-(1-metiltetrazol-5-il) tiometil-a3-cefem-4-carboxilato de sodio. - Google Patents

Un procedimiento mejorado para producir un preparado antimicrobiano de d-7(&-(4-hidroxi-6-metilnicotinamido)-4-hidroxi- fenilacetamido)-3-(1-metiltetrazol-5-il) tiometil-a3-cefem-4-carboxilato de sodio.

Info

Publication number
ES8301626A1
ES8301626A1 ES505865A ES505865A ES8301626A1 ES 8301626 A1 ES8301626 A1 ES 8301626A1 ES 505865 A ES505865 A ES 505865A ES 505865 A ES505865 A ES 505865A ES 8301626 A1 ES8301626 A1 ES 8301626A1
Authority
ES
Spain
Prior art keywords
cefem
methylnicotinamide
hydroxy
thymetil
methyletherzole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505865A
Other languages
English (en)
Other versions
ES505865A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of ES505865A0 publication Critical patent/ES505865A0/es
Publication of ES8301626A1 publication Critical patent/ES8301626A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B25—HAND TOOLS; PORTABLE POWER-DRIVEN TOOLS; MANIPULATORS
    • B25J—MANIPULATORS; CHAMBERS PROVIDED WITH MANIPULATION DEVICES
    • B25J18/00—Arms
    • B25J18/02—Arms extensible
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B25—HAND TOOLS; PORTABLE POWER-DRIVEN TOOLS; MANIPULATORS
    • B25J—MANIPULATORS; CHAMBERS PROVIDED WITH MANIPULATION DEVICES
    • B25J9/00—Program-controlled manipulators
    • B25J9/02—Program-controlled manipulators characterised by movement of the arms, e.g. cartesian coordinate type
    • B25J9/04—Program-controlled manipulators characterised by movement of the arms, e.g. cartesian coordinate type by rotating at least one arm, excluding the head movement itself, e.g. cylindrical coordinate type or polar coordinate type
    • B25J9/041—Cylindrical coordinate type

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Robotics (AREA)
  • Mechanical Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Manipulator (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

PREPARADO ANTIMICROBIANO DEL COMPUESTO D-7-<014><007>-(4-HIDROXI-6-METILNICOTINAMIDO)-4HIDROXIFENILACETAMIDO<015>-3-(1-METILTETRAZOL-5-IL)TIOMETIL-<019> - CEFEM-4-CARBOXILATO DE SODIO. UNA SOLUCION ACUOSA INYECTABLE DE ESTE COMPUESTO Y DE UN ESTABILIZADOR SE SOMETE A LIOFILIZACION. LA SOLUCION SE AJUSTA A UN PH DE 6 A 9 Y EL ESTABILIZADOR SE SELECCIONA DEL GRUPO QUE CONSISTE EN ACIDO BENZOICO, BENZOATO SODICO Y NICOTINAMIDA.
ES505865A 1980-10-01 1981-09-29 Un procedimiento mejorado para producir un preparado antimicrobiano de d-7(&-(4-hidroxi-6-metilnicotinamido)-4-hidroxi- fenilacetamido)-3-(1-metiltetrazol-5-il) tiometil-a3-cefem-4-carboxilato de sodio. Expired ES8301626A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55137939A JPS5762284A (en) 1980-10-01 1980-10-01 Stabilizing method

Publications (2)

Publication Number Publication Date
ES505865A0 ES505865A0 (es) 1983-01-01
ES8301626A1 true ES8301626A1 (es) 1983-01-01

Family

ID=15210229

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505865A Expired ES8301626A1 (es) 1980-10-01 1981-09-29 Un procedimiento mejorado para producir un preparado antimicrobiano de d-7(&-(4-hidroxi-6-metilnicotinamido)-4-hidroxi- fenilacetamido)-3-(1-metiltetrazol-5-il) tiometil-a3-cefem-4-carboxilato de sodio.

Country Status (12)

Country Link
US (1) US4880796A (es)
EP (1) EP0048944B1 (es)
JP (1) JPS5762284A (es)
KR (1) KR880001154B1 (es)
AT (1) ATE6587T1 (es)
CA (1) CA1183086A (es)
DE (1) DE3162678D1 (es)
DK (1) DK156938C (es)
ES (1) ES8301626A1 (es)
HU (1) HU184890B (es)
NO (1) NO157765C (es)
NZ (1) NZ198446A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045514A (ja) * 1983-08-22 1985-03-12 Shionogi & Co Ltd 安定な抗菌性凍結乾燥製剤
KR950010150B1 (ko) * 1986-01-14 1995-09-11 쥬우가이세이야꾸 가부시끼가이샤 니코란딜 함유 주사제의 안정화 방법
KR100609490B1 (ko) * 2000-04-17 2006-08-09 동화약품공업주식회사 항바이러스제로 유용한 6-메틸니코틴아미드 유도체
CN1305877C (zh) * 2004-07-07 2007-03-21 广州白云山医药科技发展有限公司 头孢匹胺钠的制备方法
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
CN100480251C (zh) 2007-04-18 2009-04-22 武汉同源药业有限公司 化合物头孢匹胺钠的合成方法
EP2214679B1 (en) 2007-11-13 2019-03-27 Meritage Pharma, Inc. Corticosteroid compositions
US20090143343A1 (en) 2007-11-13 2009-06-04 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
US20100216754A1 (en) * 2007-11-13 2010-08-26 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
DE102017115084A1 (de) 2017-07-06 2019-01-10 Voith Patent Gmbh Pressmantel und Verfahren zur Herstellung eines solchen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK128611B (da) * 1961-05-16 1974-06-04 Glaxo Lab Ltd Fremgangsmåde til fremstilling af derivater af cephalosporin C eller salte deraf.
US3846417A (en) * 1972-06-23 1974-11-05 Squibb & Sons Inc 1,4-cyclohexadienyl imidazolidinyl cephalosporanic acids and derivatives thereof
US3856785A (en) * 1972-07-24 1974-12-24 Squibb & Sons Inc Cephalosporin esters
US4084049A (en) * 1972-10-20 1978-04-11 Fujisawa Pharmaceutical Co., Ltd. Cepham derivatives
US3923797A (en) * 1974-03-18 1975-12-02 American Home Prod Substituted carboximidic acid esters of 7-(2-mercaptoacetamido) cephalosporanic acid derivatives
US4160087A (en) * 1974-09-06 1979-07-03 Sumitomo Chemical Company, Limited N-acylamino-α-arylacetamido cephalosporins
US4150223A (en) * 1977-02-15 1979-04-17 Merck & Co., Inc. Cephalosporin phosphonic acid, sulfonic acid and sulfonamide compounds
CA1152489A (en) * 1980-03-05 1983-08-23 Takao Okuda ANTIMICROBIAL 7- (.alpha.-ACYLAMINO-.alpha.-ARYLACETAMIDO)-3- (SUBSTITUTED METHYL) CEPHALOSPORIN COMPOUNDS, THEIR COMPOSITIONS AND PRODUCTION THEREOF

Also Published As

Publication number Publication date
ES505865A0 (es) 1983-01-01
EP0048944B1 (en) 1984-03-14
KR880001154B1 (ko) 1988-07-02
JPS6312444B2 (es) 1988-03-18
US4880796A (en) 1989-11-14
NO157765B (no) 1988-02-08
DK156938C (da) 1990-03-26
DE3162678D1 (en) 1984-04-19
NZ198446A (en) 1983-12-16
JPS5762284A (en) 1982-04-15
ATE6587T1 (de) 1984-03-15
KR830007230A (ko) 1983-10-19
DK156938B (da) 1989-10-23
NO157765C (no) 1988-06-01
EP0048944A1 (en) 1982-04-07
NO813309L (no) 1982-04-02
DK433681A (da) 1982-04-02
CA1183086A (en) 1985-02-26
HU184890B (en) 1984-10-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303