ES8302632A1 - Un procedimiento para la preparacion de derivados de 9-carbamoil-9-aminoalquilfluoreno. - Google Patents

Un procedimiento para la preparacion de derivados de 9-carbamoil-9-aminoalquilfluoreno.

Info

Publication number
ES8302632A1
ES8302632A1 ES501339A ES501339A ES8302632A1 ES 8302632 A1 ES8302632 A1 ES 8302632A1 ES 501339 A ES501339 A ES 501339A ES 501339 A ES501339 A ES 501339A ES 8302632 A1 ES8302632 A1 ES 8302632A1
Authority
ES
Spain
Prior art keywords
fluorene derivatives
preparing
preparing fluorene
fluorenes
carbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501339A
Other languages
English (en)
Other versions
ES501339A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8302632A1 publication Critical patent/ES8302632A1/es
Publication of ES501339A0 publication Critical patent/ES501339A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 9-CARBAMOIL-9-AMINOALQUILFLUORENO Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R Y R SON HIDROGENO, ALQUILO C <003> , FLUOR O CLORO; R Y R SON HIDROGENO O ALQUILO C <003> ; Y R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN 9-CARBAMOILFLUORENO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON ACRILONITRILO, EN PRESENCIA DE UNA BASE, EN UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA ENTRE 0<025>C Y 100<025>C; SEGUIDA DE LA REDUCCION DEL PRODUCTO OBTENIDO, EN PRESENCIA DE UNA AMINA DE FORMULA R R NH; Y ALQUILACION EVENTUAL DEL PRODUCTO REDUCIDO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIARRITMICA.
ES501339A 1980-04-17 1981-04-14 Un procedimiento para la preparacion de derivados de 9-carbamoil-9-aminoalquilfluoreno. Granted ES501339A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/141,229 US4282170A (en) 1980-04-17 1980-04-17 9-Carbamoyl-9-(2-cyanoethyl)fluorenes

Publications (2)

Publication Number Publication Date
ES8302632A1 true ES8302632A1 (es) 1983-01-16
ES501339A0 ES501339A0 (es) 1983-01-16

Family

ID=22494758

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501339A Granted ES501339A0 (es) 1980-04-17 1981-04-14 Un procedimiento para la preparacion de derivados de 9-carbamoil-9-aminoalquilfluoreno.

Country Status (26)

Country Link
US (1) US4282170A (es)
EP (1) EP0038676B1 (es)
JP (2) JPS574954A (es)
KR (1) KR840001071B1 (es)
AR (1) AR228596A1 (es)
AT (1) ATE9897T1 (es)
AU (1) AU543345B2 (es)
BG (1) BG35464A3 (es)
CA (1) CA1172646A (es)
CS (1) CS225833B2 (es)
DD (1) DD158395A5 (es)
DE (1) DE3166679D1 (es)
DK (1) DK172181A (es)
ES (1) ES501339A0 (es)
FI (1) FI75337C (es)
GB (1) GB2074161B (es)
GR (1) GR73824B (es)
IE (1) IE51221B1 (es)
IL (1) IL62669A (es)
NZ (1) NZ196814A (es)
PH (1) PH15857A (es)
PL (1) PL131122B1 (es)
PT (1) PT72854B (es)
RO (1) RO82739B (es)
SU (1) SU1297724A3 (es)
ZA (1) ZA812482B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552982A (en) * 1983-08-01 1985-11-12 Eli Lilly And Company Synthesis of 9-carbamoyl-9-(3-aminopropyl)fluorenes
US4508735A (en) * 1983-09-21 1985-04-02 Eli Lilly And Company Anti-arrhythmic N-alkanoylaminoalkyl fluorenes
US4585894A (en) * 1983-10-19 1986-04-29 Eli Lilly And Company Process for producing 9-carbamoyl fluorene derivatives
IL73261A (en) * 1983-10-19 1988-03-31 Lilly Co Eli Process for producing 9-carbamoyl-9-aminoalkyl fluorene derivatives,and certain intermediates thereof
US4486592A (en) * 1983-10-19 1984-12-04 Eli Lilly And Company 9-Carbamoylfluorene derivatives
US4842420A (en) * 1987-12-14 1989-06-27 Mobil Oil Corporation Variable-width draw tape for thermoplastic bags
US5736578A (en) * 1995-06-06 1998-04-07 Bristol-Myers Squibb Company Ethylamido fluorenes and improved method of making same
JP4129993B2 (ja) * 1996-01-16 2008-08-06 ブリストル―マイヤーズ・スクイブ・カンパニー ミクロソーム・トリグリセリド転移プロテインの立体配座制限芳香族抑制剤および方法
US5760246A (en) * 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
CN100463249C (zh) * 2006-01-24 2009-02-18 吉林大学 电化学沉积制备有机发光薄膜的方法及在发光器件中的应用
US7520124B2 (en) * 2006-09-12 2009-04-21 United Technologies Corporation Asymmetric serrated nozzle for exhaust noise reduction

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2280058A (en) * 1942-04-21 Cyanoethylation of carbocycijc
GB960758A (en) 1962-12-21 1964-06-17 Boehringer & Soehne Gmbh Basic fluorene derivatives
US3325544A (en) * 1965-06-10 1967-06-13 Upjohn Co 9-(2-amino-1-methylethyl) fluoren-9-ol and salts thereof
US3660485A (en) * 1970-10-05 1972-05-02 Searle & Co Fluorene-9-carboxylic acid hydrazides
US3843657A (en) * 1972-12-08 1974-10-22 Searle & Co 9-dialkylamin oalkyl-n-substituted fluorene-9-carboxamides

Also Published As

Publication number Publication date
EP0038676A1 (en) 1981-10-28
GB2074161A (en) 1981-10-28
IL62669A0 (en) 1981-06-29
FI811176L (fi) 1981-10-18
RO82739B (ro) 1984-01-30
JPH01125363A (ja) 1989-05-17
IE51221B1 (en) 1986-11-12
AU6961181A (en) 1981-10-22
PL131122B1 (en) 1984-10-31
CA1172646A (en) 1984-08-14
ES501339A0 (es) 1983-01-16
GB2074161B (en) 1984-03-14
JPH0149701B2 (es) 1989-10-25
DE3166679D1 (en) 1984-11-22
EP0038676B1 (en) 1984-10-17
GR73824B (es) 1984-05-03
JPS574954A (en) 1982-01-11
NZ196814A (en) 1984-07-06
KR840001071B1 (ko) 1984-07-31
AR228596A1 (es) 1983-03-30
PT72854A (en) 1981-05-01
BG35464A3 (en) 1984-04-15
PH15857A (en) 1983-04-13
US4282170A (en) 1981-08-04
PT72854B (en) 1982-03-30
FI75337B (fi) 1988-02-29
RO82739A (ro) 1984-01-14
JPH0153267B2 (es) 1989-11-13
PL230714A1 (es) 1982-08-02
AU543345B2 (en) 1985-04-18
ATE9897T1 (de) 1984-11-15
FI75337C (fi) 1988-06-09
DD158395A5 (de) 1983-01-12
CS225833B2 (en) 1984-02-13
SU1297724A3 (ru) 1987-03-15
IL62669A (en) 1984-06-29
IE810873L (en) 1981-10-17
DK172181A (da) 1981-10-18
KR830005110A (ko) 1983-07-23
ZA812482B (en) 1982-11-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001