ES8302772A1 - "un procedimiento para tratar termicamente con fines de inactivacion el virus de la hepatitis en una composicion de factor viii de coagulacion de la sangre humana". - Google Patents

"un procedimiento para tratar termicamente con fines de inactivacion el virus de la hepatitis en una composicion de factor viii de coagulacion de la sangre humana".

Info

Publication number
ES8302772A1
ES8302772A1 ES509941A ES509941A ES8302772A1 ES 8302772 A1 ES8302772 A1 ES 8302772A1 ES 509941 A ES509941 A ES 509941A ES 509941 A ES509941 A ES 509941A ES 8302772 A1 ES8302772 A1 ES 8302772A1
Authority
ES
Spain
Prior art keywords
factor viii
human blood
procedure
composition
inactivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509941A
Other languages
English (en)
Other versions
ES509941A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
GC Biopharma Corp
Original Assignee
Green Cross Corp
Green Cross Corp Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp, Green Cross Corp Korea filed Critical Green Cross Corp
Publication of ES509941A0 publication Critical patent/ES509941A0/es
Publication of ES8302772A1 publication Critical patent/ES8302772A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A61L2103/09—Blood or products thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA TRATAR TERMICAMENTE CON FINES DE INACTIVACION EL VIRUS DE LA HEPATITIS EN UNA COMPOSICION DE FACTOR VIII DE COAGULACION DE LA SANGRE HUMANA. SE EFECTUA EL TRATAMIENTO TERMICO A 50-80<025>C DE UNA SOLUCION QUE CONTIENE EL FACTOR VIII DE COAGULACION DE LA SANGRE HUMANA EN PRESENCIA DE UN 10% EN PESO POR VOLUMEN DE LA SOLUCION O MAS DE UN AGENTE DE ESTABILIZACION PRINCIPAL, SELECCIONADO DEL GRUPO QUE CONSISTE EN AMINOACIDOS NEUTROS, MONOSACARIDOS, OLIGOSACARIDOS Y ALCOHOLES AZUCARES, Y UN 10% EN PESO POR VOLUMEN DE LA SOLUCION O MAS DE UNA AGENTE DE ESTABILIZACION AUXILIAR, SELECCIONADO DEL GRUPO QUE CONSISTE EN SALES DE ACIDOS CARBOXILICOS HIDROXI-HIDROCARBONADOS, QUE TIENEN DE 3 A 10 ATOMOS DE CARBONO.
ES509941A 1981-10-28 1982-02-26 "un procedimiento para tratar termicamente con fines de inactivacion el virus de la hepatitis en una composicion de factor viii de coagulacion de la sangre humana". Expired ES8302772A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56173585A JPS5874617A (ja) 1981-10-28 1981-10-28 人由来血液凝固第７因子含有水溶液の加熱処理方法

Publications (2)

Publication Number Publication Date
ES509941A0 ES509941A0 (es) 1983-01-16
ES8302772A1 true ES8302772A1 (es) 1983-01-16

Family

ID=15963301

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509941A Expired ES8302772A1 (es) 1981-10-28 1982-02-26 "un procedimiento para tratar termicamente con fines de inactivacion el virus de la hepatitis en una composicion de factor viii de coagulacion de la sangre humana".

Country Status (6)

Country Link
US (1) US4446134A (es)
EP (1) EP0077870B1 (es)
JP (1) JPS5874617A (es)
AT (1) ATE44465T1 (es)
DE (1) DE3279807D1 (es)
ES (1) ES8302772A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581231A (en) * 1982-06-10 1986-04-08 The United States Of America As Represented By The Secretary Of Health And Human Services Inactivation of viruses containing essential lipids
US4650858A (en) * 1983-03-21 1987-03-17 Nordisk Gentofte A/S Concentrate of the antihemophilic factor VIII and a process for producing it
DE3330770A1 (de) * 1983-08-26 1985-03-14 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von humanplasma
US4615886A (en) * 1983-08-31 1986-10-07 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Utilizing a halohydrocarbon containing dissolved water to inactivate a lipid virus
AT389815B (de) * 1984-03-09 1990-02-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
US4797388A (en) * 1984-05-21 1989-01-10 Cetus Corporation Pharmaceutical compositions with galactitol as carrier
JPH0669961B2 (ja) * 1984-09-25 1994-09-07 株式会社ミドリ十字 免疫グロブリンの加熱処理方法
US4670394A (en) * 1984-11-16 1987-06-02 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Isolation and culture of adrenal medullary endothelial cells producing blood clotting factor VIII:C
JPH0825902B2 (ja) * 1985-02-21 1996-03-13 株式会社ミドリ十字 γ−グロブリンの加熱処理方法
AT390560B (de) * 1986-05-30 1990-05-25 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern
US4749783A (en) * 1986-07-11 1988-06-07 Miles Laboratories, Inc. Viral inactivation and purification of active proteins
DE3625090A1 (de) * 1986-07-24 1988-01-28 Behringwerke Ag Mittel zur therapie faktor viii-resistenter haemophilie a und verfahren zu seiner herstellung
GB8628104D0 (en) * 1986-11-25 1986-12-31 Connaught Lab Pasteurization of immunoglobin solutions
EP0413687A1 (en) * 1987-05-15 1991-02-27 Alan I. Rubinstein Sequential improved method for treatment of human blood-clotting factor products
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
IL86417A (en) * 1987-05-22 1992-09-06 Armour Pharma Process for the inactivation of pathogens in biological or pharmaceutical material by mixing with aqueous solution containing a sugar(alcohol)and neutral salts as stabilizers
DE3805459A1 (de) * 1988-02-22 1989-08-31 Biotest Pharma Gmbh Verfahren zur sterilisation von blut, plasma, blut- und plasmaderivaten, zellsuspensionen oder dgl.
US4939176A (en) * 1988-12-20 1990-07-03 Miles Inc. Viral inactivation process
DE4001451A1 (de) * 1990-01-19 1991-08-01 Octapharma Ag Stabile injizierbare loesungen von faktor viii und faktor ix
AT402891B (de) * 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
SE9302006D0 (sv) * 1992-10-02 1993-06-11 Kabi Pharmacia Ab Protein formulation
EP0674531A1 (de) * 1992-12-16 1995-10-04 IMMUNO Aktiengesellschaft Verfahren zur herstellung eines virussicheren biologischen präparates
JP3220539B2 (ja) * 1992-12-25 2001-10-22 日本ケミカルリサーチ株式会社 活性乳蛋白成分含有製品およびその製造法
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US6288030B1 (en) 1993-12-22 2001-09-11 Amgen Inc. Stem cell factor formulations and methods
JP4071283B2 (ja) * 1996-02-05 2008-04-02 旭化成クラレメディカル株式会社 滅菌保護剤及び滅菌方法
AUPO871997A0 (en) * 1997-08-25 1997-09-18 Csl Limited Dried biologically or therapeutically active preparations
CN1075736C (zh) * 1997-12-30 2001-12-05 长春市中心血站 高密度脂蛋白制剂的病毒灭活方法
EP1820516B1 (en) * 1999-02-22 2013-07-24 University of Connecticut Novel albumin-free factor VIII formulations
AUPR638801A0 (en) * 2001-07-13 2001-08-09 Life Therapeutics Limited Factor viii separation
KR100624013B1 (ko) * 2004-06-25 2006-09-19 주식회사 녹십자홀딩스 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제
EP2385825B1 (en) 2008-11-07 2018-10-10 University of Connecticut Factor viii formulations
ES2721311T3 (es) 2015-08-31 2019-07-30 Inst Grifols S A Procedimiento de preparación de inmunoglobulinas

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2705230A (en) * 1949-09-23 1955-03-29 Allen F Reid Method of purifying albumin
JPS51118819A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable antitrypsin
JPS51118820A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable macroglobulin
US4089944A (en) * 1975-12-22 1978-05-16 Baxter Travenol Laboratories, Inc. Rapidly solubilized AHF composition and process for preparing same
US4027013A (en) * 1976-01-22 1977-05-31 William L. Wilson Clottable fibrinogen free factor VIII and albumin product and process
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
JPS56135418A (en) * 1980-03-27 1981-10-22 Green Cross Corp:The Heat treatment of aqueous solution containing 8 factor of coagulation of blood derived from human

Also Published As

Publication number Publication date
ES509941A0 (es) 1983-01-16
JPS5874617A (ja) 1983-05-06
DE3279807D1 (en) 1989-08-17
EP0077870A3 (en) 1983-11-09
JPH0348170B2 (es) 1991-07-23
EP0077870A2 (en) 1983-05-04
US4446134A (en) 1984-05-01
EP0077870B1 (en) 1989-07-12
ATE44465T1 (de) 1989-07-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603