ES8304567A1 - "un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida". - Google Patents
"un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida".Info
- Publication number
- ES8304567A1 ES8304567A1 ES512852A ES512852A ES8304567A1 ES 8304567 A1 ES8304567 A1 ES 8304567A1 ES 512852 A ES512852 A ES 512852A ES 512852 A ES512852 A ES 512852A ES 8304567 A1 ES8304567 A1 ES 8304567A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical preparations
- preparation
- carbon atoms
- salts
- quinoleine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 2
- 229960005038 quinisocaine Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- VRNULUQTQVWDQN-UHFFFAOYSA-N n-(4,5-dihydro-1,3-thiazol-2-yl)-4-oxo-1h-quinoline-3-carboxamide Chemical class C1=NC2=CC=CC=C2C(O)=C1C(=O)NC1=NCCS1 VRNULUQTQVWDQN-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA N-DIHIDROTIAZOLIL-3-QUINOLEIN-CARBOXAMIDA Y DE SUS SALES DE ADICION DE ACIDOS, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALCOHILO C <- ; Y R PUEDE SER UNO DE VARIOS RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); Y X ES CLORO, BROMO, HIDROXI O ALCOXI C <- , CON LA 2-AMINOTIAZOLINA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE Y DE UN AGENTE DE CONDENSACION, A LA TEMPERATURA DE REFLUJO DEL MEDIO DE REACCION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANALGESICA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8111607A FR2507602A1 (fr) | 1981-06-12 | 1981-06-12 | Nouveau derive dihydrothiazole de la quinoleine, ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
| FR8204331A FR2523130A1 (fr) | 1982-03-15 | 1982-03-15 | Nouveaux derives de la n-dihydrothiazolyl-3-quinoleine carboxamide, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8304567A1 true ES8304567A1 (es) | 1983-03-01 |
| ES512852A0 ES512852A0 (es) | 1983-03-01 |
Family
ID=26222434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES512852A Granted ES512852A0 (es) | 1981-06-12 | 1982-06-04 | "un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida". |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4450166A (es) |
| EP (1) | EP0067772B1 (es) |
| KR (1) | KR880000808B1 (es) |
| AU (1) | AU552029B2 (es) |
| CA (1) | CA1216795A (es) |
| DE (1) | DE3262536D1 (es) |
| DK (1) | DK150070C (es) |
| ES (1) | ES512852A0 (es) |
| FI (1) | FI78087C (es) |
| GR (1) | GR77201B (es) |
| HU (1) | HU190796B (es) |
| IE (1) | IE53520B1 (es) |
| IL (1) | IL65943A (es) |
| MA (1) | MA19488A1 (es) |
| NZ (1) | NZ200931A (es) |
| PT (1) | PT75023B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2557570B1 (fr) * | 1984-01-04 | 1986-04-18 | Adir | Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| FR2566405B1 (fr) * | 1984-06-25 | 1986-09-26 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus |
| US4602014A (en) * | 1984-07-09 | 1986-07-22 | Ciba-Geigy Corporation | Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators |
| US4560692A (en) * | 1984-07-18 | 1985-12-24 | Hoffmann-La Roche Inc. | 4-Piperidino-2-phenylquinolines |
| US4786644A (en) * | 1987-11-27 | 1988-11-22 | Hoechst-Roussel Pharmaceuticals Inc. | 1-aryl-3-quinolinecarboxamide |
| AU2794099A (en) | 1998-02-26 | 1999-09-15 | Neurogen Corporation | Substituted cycloalkyl-4-oxonicotinic carboxamides; gaba brain receptor ligands |
| MXPA01011173A (es) * | 1999-05-06 | 2002-04-24 | Neurogen Corp | 4-0x0-quinolin-3-carboxamidas sustituidas: ligandos del receptor cerebro de gaba. |
| CA2881078C (en) | 2004-06-24 | 2018-10-02 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| US8354427B2 (en) * | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| WO2007075901A2 (en) * | 2005-12-24 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Quinolin- 4 - one derivatives as modulators of abc transporters |
| LT1993360T (lt) | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| SI3330255T1 (sl) | 2009-03-20 | 2021-03-31 | Vertex Pharmaceuticals Incorporated | Postopek izdelave regulatorja transmembranske prevodnosti pri cistični fibrozi |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| EP2819670B1 (en) | 2012-02-27 | 2026-05-20 | Vertex Pharmaceuticals Incorporated | Pharmaceutical Composition and Their Administration |
| CA2963945C (en) | 2014-10-07 | 2023-01-10 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1364605A (fr) * | 1962-03-01 | 1964-06-26 | Procédé de préparation d'amides des acides carboxyliques | |
| FR2281761A1 (fr) * | 1974-08-13 | 1976-03-12 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| FR2324304A2 (fr) * | 1975-09-22 | 1977-04-15 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| FR2340735A1 (fr) * | 1976-02-11 | 1977-09-09 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| FR2377400A2 (fr) * | 1977-01-18 | 1978-08-11 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| FR2443467A1 (fr) * | 1978-12-08 | 1980-07-04 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| FR2482596A1 (fr) * | 1980-05-19 | 1981-11-20 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament |
-
1982
- 1982-05-24 HU HU821657A patent/HU190796B/hu not_active IP Right Cessation
- 1982-05-26 MA MA19695A patent/MA19488A1/fr unknown
- 1982-06-01 IL IL65943A patent/IL65943A/xx unknown
- 1982-06-04 ES ES512852A patent/ES512852A0/es active Granted
- 1982-06-08 PT PT75023A patent/PT75023B/pt not_active IP Right Cessation
- 1982-06-09 US US06/386,597 patent/US4450166A/en not_active Expired - Fee Related
- 1982-06-10 GR GR68384A patent/GR77201B/el unknown
- 1982-06-10 FI FI822067A patent/FI78087C/fi not_active IP Right Cessation
- 1982-06-11 AU AU84827/82A patent/AU552029B2/en not_active Ceased
- 1982-06-11 CA CA000405006A patent/CA1216795A/fr not_active Expired
- 1982-06-11 DE DE8282401062T patent/DE3262536D1/de not_active Expired
- 1982-06-11 IE IE1394/82A patent/IE53520B1/en unknown
- 1982-06-11 EP EP82401062A patent/EP0067772B1/fr not_active Expired
- 1982-06-11 NZ NZ200931A patent/NZ200931A/en unknown
- 1982-06-11 KR KR8202613A patent/KR880000808B1/ko not_active Expired
- 1982-06-11 DK DK262782A patent/DK150070C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI78087C (fi) | 1989-06-12 |
| MA19488A1 (fr) | 1982-12-31 |
| US4450166A (en) | 1984-05-22 |
| AU8482782A (en) | 1982-12-16 |
| PT75023A (fr) | 1982-07-01 |
| ES512852A0 (es) | 1983-03-01 |
| CA1216795A (fr) | 1987-01-20 |
| IL65943A (en) | 1985-12-31 |
| DE3262536D1 (en) | 1985-04-18 |
| NZ200931A (en) | 1984-12-14 |
| PT75023B (fr) | 1985-05-17 |
| HU190796B (en) | 1986-11-28 |
| EP0067772B1 (fr) | 1985-03-13 |
| DK262782A (da) | 1982-12-13 |
| KR880000808B1 (ko) | 1988-05-11 |
| IE821394L (en) | 1982-12-12 |
| IL65943A0 (en) | 1982-09-30 |
| DK150070B (da) | 1986-12-01 |
| EP0067772A1 (fr) | 1982-12-22 |
| IE53520B1 (en) | 1988-12-07 |
| GR77201B (es) | 1984-09-11 |
| DK150070C (da) | 1987-11-09 |
| KR840000541A (ko) | 1984-02-25 |
| FI78087B (fi) | 1989-02-28 |
| FI822067A0 (fi) | 1982-06-10 |
| AU552029B2 (en) | 1986-05-22 |
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