ES8305710A1 - Procedimiento para preparar derivados de ciclopenteno. - Google Patents

Procedimiento para preparar derivados de ciclopenteno.

Info

Publication number
ES8305710A1
ES8305710A1 ES514592A ES514592A ES8305710A1 ES 8305710 A1 ES8305710 A1 ES 8305710A1 ES 514592 A ES514592 A ES 514592A ES 514592 A ES514592 A ES 514592A ES 8305710 A1 ES8305710 A1 ES 8305710A1
Authority
ES
Spain
Prior art keywords
represents hydrogen
hetero
preparing
processes
prostaglandin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514592A
Other languages
English (en)
Other versions
ES514592A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8305710A1 publication Critical patent/ES8305710A1/es
Publication of ES514592A0 publication Critical patent/ES514592A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/47—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CICLOPENTENO, DE FORMULA (I), EN LA QUE R ES UN GRUPO PROTECTOR DE HIDROXI DE FORMULA -CH R , DONDE R ES ARILO O ARALQUILO; Y A Y B PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA CICLIZACION DE UN DERIVADO DE HEXANODIOL DE FORMULA (II), EN LA QUE R ES EL MISMO QUE EN LA FORMULA (I) Y D PUEDE SER VARIOS RADICALES EN ATMOSFERA INERTE, CON ACETATO DE PIRROLIDINA O DE PIPERIDINA, EN UN DISOLVENTE INERTE, A TEMPERATURAS ENTRE -10 C Y LA AMBIENTE; SEGUIDA DEL TRATAMIENTO CON 1,3-PROPANODIOL, EN UN DISOLVENTE ANHIDRO, EN PRESENCIA DE ACIDO P-TOLUENSULFONICO, A TEMPERATURAS ENTRE LA AMBIENTE Y 40 C; REACCION CON ANHIDRO DIFENILSELENICO NEUTRO, A TEMPERATURA AMBIENTE; Y TRATAMIENTO CON HIDRURO DE DIISOBUTILALUMINIO EN UN DISOLVENTE INERTE, A TEMPERATURAS ENTRE -10 C Y LA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES COMO INTERMEDIARIOS PARA LA OBTENCION DE DERIVADOS DE PROSTAGLANDINA.
ES514592A 1980-08-12 1982-07-30 Procedimiento para preparar derivados de ciclopenteno. Granted ES514592A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8026240 1980-08-12
GB8113487 1981-05-01

Publications (2)

Publication Number Publication Date
ES8305710A1 true ES8305710A1 (es) 1983-04-16
ES514592A0 ES514592A0 (es) 1983-04-16

Family

ID=26276527

Family Applications (2)

Application Number Title Priority Date Filing Date
ES504681A Granted ES504681A0 (es) 1980-08-12 1981-08-11 Procedimiento para preparar derivados de 11- hidroxi-13 oxa-prostaglandina.
ES514592A Granted ES514592A0 (es) 1980-08-12 1982-07-30 Procedimiento para preparar derivados de ciclopenteno.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES504681A Granted ES504681A0 (es) 1980-08-12 1981-08-11 Procedimiento para preparar derivados de 11- hidroxi-13 oxa-prostaglandina.

Country Status (27)

Country Link
US (1) US4377704A (es)
AU (2) AU542975B2 (es)
BG (1) BG36345A3 (es)
CH (2) CH655716A5 (es)
DD (3) DD213437A5 (es)
DE (1) DE3131616A1 (es)
DK (1) DK356481A (es)
ES (2) ES504681A0 (es)
FI (1) FI812468A7 (es)
FR (2) FR2488604A1 (es)
GR (1) GR74314B (es)
HU (1) HU191416B (es)
IL (1) IL63369A (es)
IS (1) IS1184B6 (es)
IT (1) IT1214436B (es)
LU (1) LU83547A1 (es)
NL (1) NL8103710A (es)
NO (1) NO812720L (es)
NZ (1) NZ197729A (es)
OA (1) OA06879A (es)
PL (2) PL137212B1 (es)
PT (1) PT73457B (es)
RO (2) RO82680B (es)
SE (2) SE442297B (es)
SU (1) SU1187716A3 (es)
YU (2) YU193781A (es)
ZW (1) ZW17881A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8510277D0 (en) * 1985-04-23 1985-05-30 Glaxo Group Ltd Carbocyclic compounds
AU635065B2 (en) * 1989-09-08 1993-03-11 Emmanouilidis, Theo Mountable washing device
US6711436B1 (en) 1997-08-08 2004-03-23 Duke University Compositions, apparatus and methods for facilitating surgical procedures
AU758370B2 (en) * 1997-08-08 2003-03-20 Duke University Compositions, apparatus and methods for facilitating surgical procedures

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3664502A (en) * 1970-06-26 1972-05-23 Bird Machine Co Slurry screen and process of making it
US4229592A (en) * 1978-02-06 1980-10-21 Kansas University Endowment Association Intermediate for prostaglandins and process for preparing the intermediate
SE7906017L (sv) * 1978-07-11 1980-02-13 Glaxo Group Ltd Prostanoida foreningar

Also Published As

Publication number Publication date
SE442297B (sv) 1985-12-16
US4377704A (en) 1983-03-22
DE3131616A1 (de) 1982-04-22
AU3406784A (en) 1985-01-31
FR2509306A1 (fr) 1983-01-14
SE8502007D0 (sv) 1985-04-25
IS1184B6 (is) 1985-05-13
IT1214436B (it) 1990-01-18
FI812468L (fi) 1982-02-13
PL133879B1 (en) 1985-07-31
FI812468A7 (fi) 1982-02-13
HU191416B (en) 1987-02-27
SE8104703L (sv) 1982-02-13
CH650251A5 (fr) 1985-07-15
IL63369A (en) 1985-11-29
ZW17881A1 (en) 1981-10-14
AU542975B2 (en) 1985-03-28
DD202428A5 (de) 1983-09-14
YU86183A (en) 1984-04-30
RO82680B (ro) 1984-06-30
FR2488604B1 (es) 1984-11-09
SU1187716A3 (ru) 1985-10-23
DD223712A5 (de) 1985-06-19
PL137212B1 (en) 1986-05-31
IT8123455A0 (it) 1981-08-10
SE8502007L (sv) 1985-04-25
PT73457A (en) 1981-08-01
ES514592A0 (es) 1983-04-16
PT73457B (en) 1982-10-15
AU7400781A (en) 1982-03-04
ES8301465A1 (es) 1982-12-01
FR2488604A1 (fr) 1982-02-19
DK356481A (da) 1982-02-13
GR74314B (es) 1984-06-22
IS2661A7 (is) 1982-02-13
NL8103710A (nl) 1982-03-01
DD213437A5 (de) 1984-09-12
OA06879A (fr) 1983-02-28
FR2509306B1 (es) 1984-04-13
IL63369A0 (en) 1981-10-30
YU193781A (en) 1984-02-29
ES504681A0 (es) 1982-12-01
NO812720L (no) 1982-02-15
BG36345A3 (bg) 1984-10-15
NZ197729A (en) 1985-03-20
RO82680A (ro) 1984-05-12
HUT34147A (en) 1985-02-28
RO87011A (ro) 1985-05-20
LU83547A1 (fr) 1981-12-01
PL232567A1 (en) 1983-01-03
CH655716A5 (fr) 1986-05-15

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