ES8307002A1 - "procedimiento para preparar nuevos compuestos de aroilimidazol-2-onas". - Google Patents
"procedimiento para preparar nuevos compuestos de aroilimidazol-2-onas".Info
- Publication number
- ES8307002A1 ES8307002A1 ES509636A ES509636A ES8307002A1 ES 8307002 A1 ES8307002 A1 ES 8307002A1 ES 509636 A ES509636 A ES 509636A ES 509636 A ES509636 A ES 509636A ES 8307002 A1 ES8307002 A1 ES 8307002A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- aroylimidazol
- ones
- novel
- piperazino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- -1 methylenedioxy Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005360 alkyl sulfoxide group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polyurethanes Or Polyureas (AREA)
- Luminescent Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR NUEVOS COMPUESTOS DE AROILIMIDAZOL-2-ONAS. CONSISTE EN ACILAR SEGUN FRIDEL-CRAFTS UN COMPUESTOS (II) CON 1 A 10 EQUIVALENTES MOLARES DE HALURO DE BENZOILO MONOSUSTITUIDO EN LA POSICION ORTO, META O PARA, EN PRESENCIA DE UN CATALIZADOR DE ACIDO DE LEWIS EN UN DISOLVENTE A TEMPERATURAS COMPRENDIDAS ENTRE 0 C Y 100 C DURANTE UN TIEMPO DE 1 A 10 HORAS. SE OBTIENE EL COMPUESTO (I) EN QUE AR ES FENILO MONOSUSTITUIDO EN ORTO, META O PARA CON X ; X ES UN ALQUILSULFOXIDO DE CADENA RECTA O RAMIFICADA O UNA ALQUILSULFONA INFERIOR; R ES HIDROGENO, UN ALQUILO INFERIOR, UN ALQUILCARBONILO INFERIOR O UN BENZOILO; R ES HIDROGENO O UN ALQUILO INFERIOR DE CADENA RECTA O RAMIFICADA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23545381A | 1981-02-18 | 1981-02-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8307002A1 true ES8307002A1 (es) | 1983-07-01 |
| ES509636A0 ES509636A0 (es) | 1983-07-01 |
Family
ID=22885573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509636A Granted ES509636A0 (es) | 1981-02-18 | 1982-02-16 | "procedimiento para preparar nuevos compuestos de aroilimidazol-2-onas". |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0058435B1 (es) |
| JP (1) | JPS57150668A (es) |
| KR (1) | KR860001338B1 (es) |
| AT (1) | ATE24496T1 (es) |
| AU (1) | AU558789B2 (es) |
| CA (1) | CA1173047A (es) |
| DE (1) | DE3274855D1 (es) |
| DK (1) | DK161250C (es) |
| ES (1) | ES509636A0 (es) |
| GB (1) | GB2093031B (es) |
| GR (1) | GR76025B (es) |
| HK (1) | HK61586A (es) |
| IE (1) | IE52422B1 (es) |
| IL (1) | IL65010A0 (es) |
| MY (1) | MY8600710A (es) |
| NZ (1) | NZ199733A (es) |
| PH (1) | PH18106A (es) |
| ZA (1) | ZA82969B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405628A (en) * | 1981-03-05 | 1983-09-20 | Merrell Dow Pharmaceuticals Inc. | 4-Pyridylimidazolones and method of use |
| US4410540A (en) * | 1981-11-04 | 1983-10-18 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 4-aroylimidazolidin-2-ones |
| US4367236A (en) * | 1981-11-04 | 1983-01-04 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives |
| ZA826501B (en) * | 1982-09-06 | 1984-04-25 | Du Pont | Anti-hypertensive imidazole derivative |
| US4552880A (en) * | 1983-02-15 | 1985-11-12 | Merrell Dow Pharmaceuticals Inc. | Aroylimidazolones |
| US4556665A (en) * | 1984-07-09 | 1985-12-03 | Schering A.G. | Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones |
| EP1737448A1 (en) * | 2004-03-22 | 2007-01-03 | Myogen, Inc. | (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
| JP2007530566A (ja) * | 2004-03-22 | 2007-11-01 | ミオゲン インコーポレイティッド | （ｒ）−エノキシモンスルホキシドおよびｐｄｅ−ｉｉｉ媒介疾患の治療におけるその使用 |
| CN117105827A (zh) * | 2017-03-27 | 2023-11-24 | 魁北克电力公司 | 用于电解质组合物中或用作电极添加剂的盐 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA803332B (en) * | 1979-06-18 | 1981-01-28 | Richardson Merrell Inc | Novel 4-aroylimidazol-2-ones |
| NZ193935A (en) * | 1979-06-18 | 1985-05-31 | Richardson Merrell Inc | 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions |
-
1982
- 1982-02-12 PH PH26861A patent/PH18106A/en unknown
- 1982-02-14 IL IL65010A patent/IL65010A0/xx unknown
- 1982-02-15 NZ NZ199733A patent/NZ199733A/en unknown
- 1982-02-15 AU AU80486/82A patent/AU558789B2/en not_active Expired
- 1982-02-15 CA CA000396247A patent/CA1173047A/en not_active Expired
- 1982-02-15 ZA ZA82969A patent/ZA82969B/xx unknown
- 1982-02-15 GR GR67318A patent/GR76025B/el unknown
- 1982-02-16 IE IE333/82A patent/IE52422B1/en not_active IP Right Cessation
- 1982-02-16 DK DK067582A patent/DK161250C/da not_active IP Right Cessation
- 1982-02-16 ES ES509636A patent/ES509636A0/es active Granted
- 1982-02-16 JP JP57022154A patent/JPS57150668A/ja active Granted
- 1982-02-17 GB GB8204721A patent/GB2093031B/en not_active Expired
- 1982-02-18 EP EP82101233A patent/EP0058435B1/en not_active Expired
- 1982-02-18 AT AT82101233T patent/ATE24496T1/de not_active IP Right Cessation
- 1982-02-18 DE DE8282101233T patent/DE3274855D1/de not_active Expired
- 1982-02-18 KR KR8200715A patent/KR860001338B1/ko not_active Expired
-
1986
- 1986-08-21 HK HK615/86A patent/HK61586A/xx not_active IP Right Cessation
- 1986-12-30 MY MY710/86A patent/MY8600710A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH18106A (en) | 1985-03-21 |
| DK161250C (da) | 1991-12-09 |
| AU8048682A (en) | 1982-08-26 |
| CA1173047A (en) | 1984-08-21 |
| KR830009045A (ko) | 1983-12-17 |
| JPS57150668A (en) | 1982-09-17 |
| IE820333L (en) | 1982-08-18 |
| ES509636A0 (es) | 1983-07-01 |
| KR860001338B1 (ko) | 1986-09-15 |
| HK61586A (en) | 1986-08-29 |
| IL65010A0 (en) | 1982-04-30 |
| GR76025B (es) | 1984-08-03 |
| EP0058435A2 (en) | 1982-08-25 |
| EP0058435A3 (en) | 1984-03-21 |
| NZ199733A (en) | 1985-05-31 |
| ATE24496T1 (de) | 1987-01-15 |
| DK67582A (da) | 1982-08-19 |
| DK161250B (da) | 1991-06-17 |
| DE3274855D1 (de) | 1987-02-05 |
| GB2093031B (en) | 1984-10-24 |
| IE52422B1 (en) | 1987-10-28 |
| ZA82969B (en) | 1983-09-28 |
| AU558789B2 (en) | 1987-02-12 |
| JPH048421B2 (es) | 1992-02-17 |
| EP0058435B1 (en) | 1986-12-30 |
| MY8600710A (en) | 1986-12-31 |
| GB2093031A (en) | 1982-08-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1026147T3 (da) | Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater | |
| ES8400422A1 (es) | "procedimiento de preparacion de eteres triciclicos, asi como de sus sales de adicion con un acido mineral u organico terapeuticamente compatible". | |
| AU558789B2 (en) | 4-aroylimidazol-2-ones | |
| ES2073398T3 (es) | Nuevos derivados substituidos del acido bencilideno- y cinamilideno-malonico con actividad como inhibidores de la proliferacion celular. | |
| ES8603711A1 (es) | Procedimiento para preparar compuestos benzimidazoles 2-piridilmetil-tio y sulfinil substituidos | |
| ATE75743T1 (de) | Hydrazinderivate und ihre verwendung. | |
| ATE46146T1 (de) | Phenylpiperidinderivat und seine salze, ihre herstellung, sie enthaltende zusammensetzungen und ihre therapeutische verwendung. | |
| PL255089A1 (en) | Method of obtaining novel derivatives of three-ring oxindolocarbonamide | |
| YU48063B (sh) | Novi derivati 3,4-dihidroizohinolina i postupci za njihovo pripremanje | |
| ES2152379T3 (es) | Dihidropiridinas condensadas y su utilizacion para la produccion de preparados farmaceuticos. | |
| AU552310B2 (en) | 4-aroylimidazolin-2-ones | |
| GR3023757T3 (en) | Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents. | |
| MA24197A1 (fr) | Nouvelles fungarrestines | |
| ES8704478A1 (es) | Procedimiento para la obtencion de derivados de piridina | |
| FR2230349A1 (en) | 1-Phenyl-2-methyl-5-methoxy indoles - with e.g. sedative, cardiac analeptic, vasodilator, antihypertensive, analgesic, and antiinflammatory activities | |
| ITMI911095A0 (it) | Composizioni farmaceutiche contenenti l'estere 4-(2 metilamminoetil)- 1,2- fenilenicodell`acido 2-metilpropanoico per il trattamento della neurootticopatia glaucomatosa | |
| ES8406489A1 (es) | Procedimiento para la obtencion de derivados de pirano-pirazol | |
| JPS55104266A (en) | Novel pyridone derivative | |
| ES2009283A6 (es) | Procedimiento para preparar nuevos aminoacilatos de glicerol-acetal. | |
| MX9804482A (es) | Quinolinas y quinazolinas utiles en terapias. | |
| JPS5430166A (en) | 2-aminomethyl-5-phenyloxazoles and their pharmaceutically acceptable acid salts |