ES8400441A1 - "procedimiento para la produccion de 1-azaxantona". - Google Patents

"procedimiento para la produccion de 1-azaxantona".

Info

Publication number
ES8400441A1
ES8400441A1 ES515897A ES515897A ES8400441A1 ES 8400441 A1 ES8400441 A1 ES 8400441A1 ES 515897 A ES515897 A ES 515897A ES 515897 A ES515897 A ES 515897A ES 8400441 A1 ES8400441 A1 ES 8400441A1
Authority
ES
Spain
Prior art keywords
azaxanthone
processes
production
pharmaceutical compositions
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515897A
Other languages
English (en)
Other versions
ES515897A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lacer SA
Original Assignee
Lacer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer SA filed Critical Lacer SA
Publication of ES515897A0 publication Critical patent/ES515897A0/es
Publication of ES8400441A1 publication Critical patent/ES8400441A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1-AZAXANTONA.CONSISTE EN LA REACCION DE CICLIZACION DE ACIDO 2-FENOXINICOTINICO POR CALENTAMIENTO A UNA TEMPERATURA ENTRE 160JC Y 200JC EN PRESENCIA DE ACIDO POLIFOSFORICO COMO AGENTE DESHIDRATANTE. LA REACCION SE LLEVA A CABO AÑADIENDO EL ACIDO 2-FENOXINICOTINICO SOBRE 5-10 VECES SU PESO DE ACIDO POLIFOSFORICO DE 80-85, EXPRESADO EN P2O5, PREVIAMENTE CALENTADO. LA MEZCLA DE REACCION SE DILUYE CON AGUA, SE NEUTRALIZA HASTA PH 2-3 CON ALCALI Y SE SEPARA DE LA 1-AZAXANTONA.LA 1-AZAXANTONA TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANALGESICA, ANTIPIRETICA,ANTIINFLAMATORIA, ESPASMOLITICA, BRONCODILATADORA Y DIURETICA.
ES515897A 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona". Expired ES8400441A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP81107651A EP0075607B1 (en) 1981-09-25 1981-09-25 1-azaxanthone for use as therapeutic agent, processes for its production and pharmaceutical compositions

Publications (2)

Publication Number Publication Date
ES515897A0 ES515897A0 (es) 1983-11-16
ES8400441A1 true ES8400441A1 (es) 1983-11-16

Family

ID=8187931

Family Applications (2)

Application Number Title Priority Date Filing Date
ES515898A Expired ES8308886A1 (es) 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona".
ES515897A Expired ES8400441A1 (es) 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES515898A Expired ES8308886A1 (es) 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona".

Country Status (7)

Country Link
US (1) US4623648A (es)
EP (1) EP0075607B1 (es)
JP (1) JPS5867618A (es)
AT (1) ATE12072T1 (es)
DE (1) DE3169269D1 (es)
ES (2) ES8308886A1 (es)
PT (2) PT75582A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE902790A (fr) * 1984-07-12 1986-01-02 Sandoz Sa Procede de preparation de xanthones et de thioxanthones.
US5565413A (en) * 1994-12-06 1996-10-15 Zeneca Limited Substituted pyridyl phenyl ketone herbicides
JP4510156B2 (ja) * 1997-03-03 2010-07-21 サノフィーアベンティス 難溶性薬剤物質を含有する医薬製剤
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
EP2671507A3 (en) 2005-04-28 2014-02-19 Proteus Digital Health, Inc. Pharma-informatics system
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
CA2752373C (en) 2009-02-20 2017-10-10 To-Bbb Holding B.V. Glutathione-based drug delivery system
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803153A (en) 1970-11-16 1974-04-09 Schering Corp Benzopyrano pyridines
JPS5619350B2 (es) * 1972-07-21 1981-05-07
JPS5919113B2 (ja) * 1975-02-03 1984-05-02 ウェルファイド株式会社 新規なベンゾピラノピリジン誘導体の製法
JPS5195097A (ja) * 1975-02-08 1976-08-20 Benzopiranopirijinjudotainoseizoho

Also Published As

Publication number Publication date
JPS5867618A (ja) 1983-04-22
PT75582A (fr) 1982-10-01
ES515897A0 (es) 1983-11-16
PT75581B (fr) 1985-05-31
JPH0354645B2 (es) 1991-08-20
US4623648A (en) 1986-11-18
ATE12072T1 (de) 1985-03-15
PT75581A (fr) 1982-10-01
EP0075607B1 (en) 1985-03-13
EP0075607A1 (en) 1983-04-06
ES515898A0 (es) 1983-10-16
ES8308886A1 (es) 1983-10-16
DE3169269D1 (en) 1985-04-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519