ES8308886A1 - "procedimiento para la produccion de 1-azaxantona". - Google Patents

"procedimiento para la produccion de 1-azaxantona".

Info

Publication number
ES8308886A1
ES8308886A1 ES515898A ES515898A ES8308886A1 ES 8308886 A1 ES8308886 A1 ES 8308886A1 ES 515898 A ES515898 A ES 515898A ES 515898 A ES515898 A ES 515898A ES 8308886 A1 ES8308886 A1 ES 8308886A1
Authority
ES
Spain
Prior art keywords
azaxanthone
processes
production
pharmaceutical compositions
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515898A
Other languages
English (en)
Other versions
ES515898A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lacer SA
Original Assignee
Lacer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer SA filed Critical Lacer SA
Publication of ES8308886A1 publication Critical patent/ES8308886A1/es
Publication of ES515898A0 publication Critical patent/ES515898A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1-AZAXANTONA. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (I), EN LA QUE X ES CLORO, BROMO O ALCOXI C<1<-<4; Y R ES HALOGENO, HIDROXILO O ALCOXI C<1<-<4, CON ACIDO CLORHIDRICO O BROMHIDRICO CONCENTRADOS. LA REACCION SE LLEVA A CABO POR CALENTAMIENTO A REFLUJO. LA 1-AZAXANTONA SE SEPARA DE LA MEZCLA DE REACCION Y PURIFICA SIGUIENDO METODOS CONVENCIONALES. LA 1-AZAXANTONA TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANALGESICA, ANTIPIRETICA, ANTIINFLAMATORIA, ESPALMOLITICA, BRONCODILATADORA Y DIURETICA.
ES515898A 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona". Granted ES515898A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP81107651A EP0075607B1 (en) 1981-09-25 1981-09-25 1-azaxanthone for use as therapeutic agent, processes for its production and pharmaceutical compositions

Publications (2)

Publication Number Publication Date
ES8308886A1 true ES8308886A1 (es) 1983-10-16
ES515898A0 ES515898A0 (es) 1983-10-16

Family

ID=8187931

Family Applications (2)

Application Number Title Priority Date Filing Date
ES515898A Granted ES515898A0 (es) 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona".
ES515897A Granted ES515897A0 (es) 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES515897A Granted ES515897A0 (es) 1981-09-25 1982-09-23 "procedimiento para la produccion de 1-azaxantona".

Country Status (7)

Country Link
US (1) US4623648A (es)
EP (1) EP0075607B1 (es)
JP (1) JPS5867618A (es)
AT (1) ATE12072T1 (es)
DE (1) DE3169269D1 (es)
ES (2) ES515898A0 (es)
PT (2) PT75582A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1200085B (it) * 1984-07-12 1989-01-05 Sandoz Ag Procedimento per la preparazione di xantoni e di tioxantoni
US5565413A (en) * 1994-12-06 1996-10-15 Zeneca Limited Substituted pyridyl phenyl ketone herbicides
BR9808136A (pt) * 1997-03-03 2000-03-28 Sanofi Synthelabo Formulações farmacêuticas contendo substâncias medicamentosas fracamente solúveis.
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803153A (en) 1970-11-16 1974-04-09 Schering Corp Benzopyrano pyridines
JPS5619350B2 (es) * 1972-07-21 1981-05-07
JPS5919113B2 (ja) * 1975-02-03 1984-05-02 ウェルファイド株式会社 新規なベンゾピラノピリジン誘導体の製法
JPS5195097A (ja) * 1975-02-08 1976-08-20 Benzopiranopirijinjudotainoseizoho

Also Published As

Publication number Publication date
PT75581A (fr) 1982-10-01
PT75582A (fr) 1982-10-01
ES8400441A1 (es) 1983-11-16
JPS5867618A (ja) 1983-04-22
ATE12072T1 (de) 1985-03-15
US4623648A (en) 1986-11-18
DE3169269D1 (en) 1985-04-18
JPH0354645B2 (es) 1991-08-20
EP0075607B1 (en) 1985-03-13
PT75581B (fr) 1985-05-31
ES515897A0 (es) 1983-11-16
ES515898A0 (es) 1983-10-16
EP0075607A1 (en) 1983-04-06

Similar Documents

Publication Publication Date Title
DE3169269D1 (en) 1-azaxanthone for use as therapeutic agent, processes for its production and pharmaceutical compositions
US2957883A (en) Sulfamyl derivatives of certain saccharins and process
AR248394A1 (es) Procedimiento para obtener nuevos derivados de la n-bencilpiridina.
CA1132562A (en) Halogeno derivatives of isopropylamino pyrimidine, their preparation and therapeutic use
ES8505178A1 (es) Procedimiento para la obtencion de derivados quinolinicos
DE3570979D1 (en) An ester of (+)6-methoxy- alpha -methyl-2-naphtalene acetic acid having mucosecretolytic, anti-inflammatory, analgesic, antipyretic activity, a process for its preparation and pharmaceutical compositions thereof
Jarman et al. Synthesis of tritium-labeled chlorambucil and aniline mustard of high specific activity
Lednicer et al. Synthesis and Antifertility Activity of 4-and5-(ι-Arylalkyl) oxazolidinethiones
JPS5239622A (en) Process for preparation of methacrylic acid
ES8307006A1 (es) Procedimiento de preparar nuevos derivados de aprovincaminol.
ES8205747A1 (es) Procedimiento de preparacion de un compuesto util en el tra-tamiento de la psoriasis
DE3572171D1 (en) Theophylline-7-acetic acid ester of d,l-trans-sobrerol having mucosecretolytic-fluidizing and antibronchospastic activity, a process for its preparation and pharmaceutical compositions thereof
ES8301230A1 (es) Un procedimiento para la preparacion de 1-fenil-5-amidotetrazoles.
JPS5661365A (en) Dimethoxyphthalazinone derivative and its preparation
ES8304146A1 (es) &#34;procedimiento de obtencion del ester orto fosforico de la serina&#34;.
US3789120A (en) Sulfamoyl azide process and composition for lowering blood pressure
US3597479A (en) Substituted anilino benzyl alcohols
JPS57106668A (en) Preparation of n,n&#39;-bis-(3-(3&#39;,4&#39;,5&#39;-trimethoxybenzoyloxy)- propyl)homopiperazine
ES8201974A1 (es) Procedimiento para preparar nuevos compuestos de quinolona
FR2367075A1 (fr) Nouvelles tropinones substituees en position 6 et procede pour leur preparation
JPS5277093A (en) Preparation of condensed quinazoline derivative
ES8300338A1 (es) Un procedimiento para la preparacion de derivados de acido fosfinico y fosfonico.
ES8301875A1 (es) &#34;procedimiento de obtencion de derivados de bifenilo&#34;.
ES8301960A1 (es) Procedimiento de obtencion de nuevos derivados del acido 2- hidroxibenzoico
JPS51128998A (en) Process for preparing 4-hydroxy-1h- pyrazolo (3,4-d) pyrimidine

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401