ES8401075A1 - "procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas". - Google Patents

"procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas".

Info

Publication number
ES8401075A1
ES8401075A1 ES512275A ES512275A ES8401075A1 ES 8401075 A1 ES8401075 A1 ES 8401075A1 ES 512275 A ES512275 A ES 512275A ES 512275 A ES512275 A ES 512275A ES 8401075 A1 ES8401075 A1 ES 8401075A1
Authority
ES
Spain
Prior art keywords
hydrogen
hypertensive
substituted
procedure
alcohyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512275A
Other languages
English (en)
Other versions
ES512275A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES8401075A1 publication Critical patent/ES8401075A1/es
Publication of ES512275A0 publication Critical patent/ES512275A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ESPIRO PIPERIDINO-OXOBENZOXACINAS SUSTITUIDAS EN POSICION 1 ANTI-HIPERTENSIVAS, DE FORMULA GENERAL (I), EN LA QUE R1, R2, R3 Y R4 SON, CADA UNO DE ELLOS INDEPENDIENTEMENTE, HIDROGENO, HIDROXI O HALO; R ES HIDROGENO O ALCOHILO INFERIOR; Y A SE SELECCIONA ENTRE 2-(BENZODIOXAN-2-IL)-2-HIDROXIETILO, 3-(ARILOXI)-2-HIDROXIPROPILO, V-ARILALCOHILO Y V-ARIL-V-OXO-ALCOHILO, Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN TRATAR UN COMPUESTO DE FORMULA (II), EN DONDE R1, R2, R3 Y R4 TIENEN LOS SIGNIFICADOS YA INDICADOS;Y R ES HIDROGENO O ALCOHILO INFERIOR, CON UN COMPUESTO SELECCIONADO DEL GRUPO DE FORMULA (III), EN DONDE A ES V-(BENZODIOXAN-2-IL)-ALCO HILO, V-ARILOXIALCOHILO O V-ARIL-V-OXO-ALCOHILO.DE APLICACION EN EL TRATAMIENTO DE LA HIPERTENSION.
ES512275A 1981-05-18 1982-05-17 "procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas". Granted ES512275A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/264,779 US4349549A (en) 1981-05-18 1981-05-18 Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s

Publications (2)

Publication Number Publication Date
ES8401075A1 true ES8401075A1 (es) 1983-12-01
ES512275A0 ES512275A0 (es) 1983-12-01

Family

ID=23007572

Family Applications (3)

Application Number Title Priority Date Filing Date
ES512275A Granted ES512275A0 (es) 1981-05-18 1982-05-17 "procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas".
ES521124A Granted ES521124A0 (es) 1981-05-18 1983-03-30 Procedimiento para preparar espino (piperidino-oxobenzo-xazinas) substituidas en posicion 1 anti-hipertensivas.
ES521125A Expired ES8404791A1 (es) 1981-05-18 1983-03-30 Procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES521124A Granted ES521124A0 (es) 1981-05-18 1983-03-30 Procedimiento para preparar espino (piperidino-oxobenzo-xazinas) substituidas en posicion 1 anti-hipertensivas.
ES521125A Expired ES8404791A1 (es) 1981-05-18 1983-03-30 Procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas.

Country Status (20)

Country Link
US (1) US4349549A (es)
EP (1) EP0065864B1 (es)
JP (1) JPS57193485A (es)
KR (1) KR830010115A (es)
AT (1) ATE15198T1 (es)
AU (1) AU8376982A (es)
BR (1) BR8202861A (es)
DE (1) DE3265802D1 (es)
DK (1) DK221882A (es)
ES (3) ES512275A0 (es)
FI (1) FI821733A7 (es)
HU (1) HU186933B (es)
IE (1) IE53034B1 (es)
IL (1) IL65801A (es)
NO (1) NO821616L (es)
NZ (1) NZ200631A (es)
PH (1) PH20072A (es)
PL (2) PL236472A1 (es)
PT (1) PT74912B (es)
ZA (1) ZA823414B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5815979A (ja) * 1981-07-11 1983-01-29 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体およびその製造法
JPS5959685A (ja) * 1982-09-28 1984-04-05 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
GB2131021B (en) * 1982-11-24 1985-12-18 Erba Farmitalia Antipsychotic benzoxazines
US4558049A (en) * 1982-11-24 1985-12-10 Farmitalia Carlo Erba S.P.A. Antipsycotic benzoxazines
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
SE9202218D0 (sv) * 1992-07-22 1992-07-22 Kabi Pharmacia Ab Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation
US6374762B1 (en) * 1997-10-27 2002-04-23 Correct Craft, Inc. Water sport towing apparatus
WO2001045707A1 (en) * 1999-12-21 2001-06-28 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU2001230537A1 (en) * 2000-02-01 2001-08-14 Daiichi Pharmaceutical Co., Ltd. Pyridoxazine derivatives
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
EP2374455A3 (en) 2004-08-19 2012-03-28 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
RU2007124373A (ru) * 2004-11-29 2009-01-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецептеров
AU2006330866A1 (en) * 2005-12-22 2007-07-05 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
US7351706B2 (en) * 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
AU2007221214A1 (en) 2006-02-22 2007-09-07 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
KR20080098070A (ko) * 2006-02-22 2008-11-06 버텍스 파마슈티칼스 인코포레이티드 무스카린성 수용체의 조절제로서의 스피로 축합된 피페리딘
CN101500565A (zh) * 2006-06-29 2009-08-05 弗特克斯药品有限公司 毒蕈碱性受体的调节剂
AU2007284548A1 (en) * 2006-08-15 2008-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
CA2660974A1 (en) * 2006-08-18 2008-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
JP2010540640A (ja) * 2007-10-03 2010-12-24 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン作用性レセプターのモジュレーター
CN113264949B (zh) * 2021-05-31 2022-04-05 西南大学 一类螺苯并噁嗪哌啶α,β-不饱和酮类衍生物的设计合成与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA952908A (en) * 1970-02-27 1974-08-13 Yoshitomi Pharmaceutical Industries Benzodioxane derivatives
FR2420536A1 (fr) * 1978-03-22 1979-10-19 Roussel Uclaf Nouveaux derives de 1,3-dihydro 3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl)2-hydroxyethyl/piperidin-4-yl/2h-indol-2-one, procede pour leur preparation et application comme medicaments

Also Published As

Publication number Publication date
IE821179L (en) 1982-11-18
US4349549A (en) 1982-09-14
FI821733A0 (fi) 1982-05-17
NZ200631A (en) 1985-10-11
IL65801A (en) 1985-09-29
JPS57193485A (en) 1982-11-27
IE53034B1 (en) 1988-05-11
BR8202861A (pt) 1983-04-26
FI821733A7 (fi) 1982-11-19
AU8376982A (en) 1982-11-25
ES512275A0 (es) 1983-12-01
PT74912A (en) 1982-06-01
EP0065864A1 (en) 1982-12-01
EP0065864B1 (en) 1985-08-28
ES8404790A1 (es) 1984-06-01
KR830010115A (ko) 1983-12-26
PH20072A (en) 1986-09-18
HU186933B (en) 1985-10-28
PL246771A1 (en) 1984-10-22
IL65801A0 (en) 1982-08-31
DK221882A (da) 1982-11-19
ES521124A0 (es) 1984-06-01
ES521125A0 (es) 1984-06-01
PT74912B (en) 1983-12-07
ATE15198T1 (de) 1985-09-15
NO821616L (no) 1982-11-19
ZA823414B (en) 1983-12-28
PL236472A1 (en) 1984-07-30
ES8404791A1 (es) 1984-06-01
DE3265802D1 (en) 1985-10-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001