ATE15198T1 - Blutdrucksenkende 1-substituierte spiro(piperidin-oxobenzoxazine). - Google Patents

Blutdrucksenkende 1-substituierte spiro(piperidin-oxobenzoxazine).

Info

Publication number
ATE15198T1
ATE15198T1 AT82302494T AT82302494T ATE15198T1 AT E15198 T1 ATE15198 T1 AT E15198T1 AT 82302494 T AT82302494 T AT 82302494T AT 82302494 T AT82302494 T AT 82302494T AT E15198 T1 ATE15198 T1 AT E15198T1
Authority
AT
Austria
Prior art keywords
omega
aryl
halo
lower alkyl
group
Prior art date
Application number
AT82302494T
Other languages
English (en)
Inventor
Adolph Peter Roszkowski
Robin Douglas Clark
Arthur Frederick Kluge
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of ATE15198T1 publication Critical patent/ATE15198T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT82302494T 1981-05-18 1982-05-17 Blutdrucksenkende 1-substituierte spiro(piperidin-oxobenzoxazine). ATE15198T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/264,779 US4349549A (en) 1981-05-18 1981-05-18 Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s
EP82302494A EP0065864B1 (de) 1981-05-18 1982-05-17 Blutdrucksenkende 1-substituierte Spiro(piperidin-oxobenzoxazine)

Publications (1)

Publication Number Publication Date
ATE15198T1 true ATE15198T1 (de) 1985-09-15

Family

ID=23007572

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82302494T ATE15198T1 (de) 1981-05-18 1982-05-17 Blutdrucksenkende 1-substituierte spiro(piperidin-oxobenzoxazine).

Country Status (20)

Country Link
US (1) US4349549A (de)
EP (1) EP0065864B1 (de)
JP (1) JPS57193485A (de)
KR (1) KR830010115A (de)
AT (1) ATE15198T1 (de)
AU (1) AU8376982A (de)
BR (1) BR8202861A (de)
DE (1) DE3265802D1 (de)
DK (1) DK221882A (de)
ES (3) ES8401075A1 (de)
FI (1) FI821733A7 (de)
HU (1) HU186933B (de)
IE (1) IE53034B1 (de)
IL (1) IL65801A (de)
NO (1) NO821616L (de)
NZ (1) NZ200631A (de)
PH (1) PH20072A (de)
PL (2) PL236472A1 (de)
PT (1) PT74912B (de)
ZA (1) ZA823414B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5815979A (ja) * 1981-07-11 1983-01-29 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体およびその製造法
JPS5959685A (ja) * 1982-09-28 1984-04-05 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
US4558049A (en) * 1982-11-24 1985-12-10 Farmitalia Carlo Erba S.P.A. Antipsycotic benzoxazines
GB2131021B (en) * 1982-11-24 1985-12-18 Erba Farmitalia Antipsychotic benzoxazines
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
SE9202218D0 (sv) * 1992-07-22 1992-07-22 Kabi Pharmacia Ab Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation
US6374762B1 (en) * 1997-10-27 2002-04-23 Correct Craft, Inc. Water sport towing apparatus
WO2001045707A1 (en) * 1999-12-21 2001-06-28 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU2001230537A1 (en) * 2000-02-01 2001-08-14 Daiichi Pharmaceutical Co., Ltd. Pyridoxazine derivatives
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
US7879834B2 (en) 2004-08-19 2011-02-01 Vertex Pharmaceuticals Incorporated Spiroindoline modulators of muscarinic receptors
JP2008521825A (ja) * 2004-11-29 2008-06-26 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体のモジュレーター
CA2634456A1 (en) * 2005-12-22 2007-07-05 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
US7351706B2 (en) * 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
RU2008137583A (ru) * 2006-02-22 2010-03-27 Вертекс Фармасьютикалз Инкорпорейшн (Us) Спиропиперидины в качестве модуляторов мускариновых рецепторов
US8003660B2 (en) 2006-02-22 2011-08-23 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
US7858790B2 (en) * 2006-06-29 2010-12-28 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
CN101553231A (zh) * 2006-08-15 2009-10-07 弗特克斯药品有限公司 毒蕈碱受体调节剂
US7786107B2 (en) * 2006-08-18 2010-08-31 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
JP2010540640A (ja) * 2007-10-03 2010-12-24 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン作用性レセプターのモジュレーター
CN113264949B (zh) * 2021-05-31 2022-04-05 西南大学 一类螺苯并噁嗪哌啶α,β-不饱和酮类衍生物的设计合成与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA952908A (en) * 1970-02-27 1974-08-13 Yoshitomi Pharmaceutical Industries Benzodioxane derivatives
FR2420536A1 (fr) * 1978-03-22 1979-10-19 Roussel Uclaf Nouveaux derives de 1,3-dihydro 3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl)2-hydroxyethyl/piperidin-4-yl/2h-indol-2-one, procede pour leur preparation et application comme medicaments

Also Published As

Publication number Publication date
EP0065864B1 (de) 1985-08-28
KR830010115A (ko) 1983-12-26
IE53034B1 (en) 1988-05-11
FI821733A0 (fi) 1982-05-17
DK221882A (da) 1982-11-19
EP0065864A1 (de) 1982-12-01
IL65801A0 (en) 1982-08-31
US4349549A (en) 1982-09-14
PH20072A (en) 1986-09-18
AU8376982A (en) 1982-11-25
NO821616L (no) 1982-11-19
ES8404791A1 (es) 1984-06-01
PT74912A (en) 1982-06-01
JPS57193485A (en) 1982-11-27
PL236472A1 (en) 1984-07-30
ES521125A0 (es) 1984-06-01
NZ200631A (en) 1985-10-11
ES512275A0 (es) 1983-12-01
FI821733A7 (fi) 1982-11-19
PT74912B (en) 1983-12-07
ES8401075A1 (es) 1983-12-01
ZA823414B (en) 1983-12-28
ES8404790A1 (es) 1984-06-01
BR8202861A (pt) 1983-04-26
DE3265802D1 (en) 1985-10-03
PL246771A1 (en) 1984-10-22
HU186933B (en) 1985-10-28
IL65801A (en) 1985-09-29
IE821179L (en) 1982-11-18
ES521124A0 (es) 1984-06-01

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