ES8401445A1 - Un procedimiento para obtener compuestos biciclicos derivados del indano o benzociclohexano. - Google Patents

Un procedimiento para obtener compuestos biciclicos derivados del indano o benzociclohexano.

Info

Publication number
ES8401445A1
ES8401445A1 ES515269A ES515269A ES8401445A1 ES 8401445 A1 ES8401445 A1 ES 8401445A1 ES 515269 A ES515269 A ES 515269A ES 515269 A ES515269 A ES 515269A ES 8401445 A1 ES8401445 A1 ES 8401445A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
bicyclic compounds
production
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515269A
Other languages
English (en)
Other versions
ES515269A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55154394A external-priority patent/JPS5777651A/ja
Priority claimed from JP56064371A external-priority patent/JPS57179141A/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8401445A1 publication Critical patent/ES8401445A1/es
Publication of ES515269A0 publication Critical patent/ES515269A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS BICICLICOS DERIVADOS DEL INDANO Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FOMRULA (I), EN LA QUE M Y N VALEN 1 O 2; Y R1-R6 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO, DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III), EN LAS QUE X ES HALOGENO O UN GRUPO DE FORMULA R7SO2-O-, SIENDO R7 ALCOHILO C1-4, FENILO O P-TOLILO, Y LOS DEMAS SIMBOLOS TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, A UNATEMPERATURA ENTRE C10JC Y 150JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA LA PREVENCION O TRATAMIENTO DE LA HIPERTENSION Y COMO ANALGESICOS.
ES515269A 1980-10-31 1982-08-26 Un procedimiento para obtener compuestos biciclicos derivados del indano o benzociclohexano. Granted ES515269A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP55154394A JPS5777651A (en) 1980-10-31 1980-10-31 Indane derivative and its preparation
JP56064371A JPS57179141A (en) 1981-04-28 1981-04-28 Bicyclic compound and its preparation

Publications (2)

Publication Number Publication Date
ES8401445A1 true ES8401445A1 (es) 1983-12-01
ES515269A0 ES515269A0 (es) 1983-12-01

Family

ID=26405485

Family Applications (3)

Application Number Title Priority Date Filing Date
ES506714A Expired ES8306710A1 (es) 1980-10-31 1981-10-30 Un procedimiento para obtener compuestos biciclicos
ES515269A Granted ES515269A0 (es) 1980-10-31 1982-08-26 Un procedimiento para obtener compuestos biciclicos derivados del indano o benzociclohexano.
ES524148A Expired ES8504671A1 (es) 1980-10-31 1983-07-15 Un procedimiento para obtener compuestos biciclicos derivados del indano o benzociclohexano

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES506714A Expired ES8306710A1 (es) 1980-10-31 1981-10-30 Un procedimiento para obtener compuestos biciclicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES524148A Expired ES8504671A1 (es) 1980-10-31 1983-07-15 Un procedimiento para obtener compuestos biciclicos derivados del indano o benzociclohexano

Country Status (19)

Country Link
US (3) US4822818A (es)
EP (1) EP0051391B1 (es)
KR (1) KR880000890B1 (es)
AU (1) AU543804B2 (es)
CA (1) CA1287444C (es)
DE (1) DE3165862D1 (es)
DK (1) DK164917C (es)
ES (3) ES8306710A1 (es)
FI (1) FI73698C (es)
GB (1) GB2086393B (es)
GR (1) GR75368B (es)
HK (1) HK19887A (es)
HU (1) HU183652B (es)
IE (1) IE51918B1 (es)
MY (1) MY8500500A (es)
NO (1) NO155133C (es)
NZ (1) NZ198826A (es)
PH (2) PH18357A (es)
PT (1) PT73912B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906615A (en) * 1980-12-18 1990-03-06 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4610816A (en) * 1980-12-18 1986-09-09 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4596791A (en) * 1983-03-16 1986-06-24 Usv Pharmaceutical Corp. Compounds for treating hypertension
US4666906A (en) * 1983-03-16 1987-05-19 Usv Pharmaceutical Corporation Compounds for treating hypertension
AT387717B (de) * 1983-03-16 1989-03-10 Immuno Ag Verfahren zum bestimmen von unvertraeglichkeitsreaktionen verursachenden substanzen in therapeutisch und prophylaktisch anzuwendenden blutprodukten sowie verwendung des verfahrens
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
US4638000A (en) * 1983-08-12 1987-01-20 Takeda Chemical Industries, Ltd. Condensed seven-membered ring compounds, their production and use
IL72523A (en) * 1983-08-12 1988-06-30 Takeda Chemical Industries Ltd 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
GB8414987D0 (en) * 1984-06-12 1984-07-18 Beecham Group Plc Active compounds
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use
DK100788A (da) * 1987-03-04 1988-09-05 Takeda Chemical Industries Ltd Fremgangsmaade til fremstilling af indanderivater
EP0284510A3 (en) * 1987-03-24 1990-08-22 Asahi Breweries, Ltd. N-[N alpha-(1(S)-carboxy-3-cyclohexyl-propyl)-1-lysyl] N-cyclopentylglycine as antihypertensives
US4956490A (en) * 1989-03-09 1990-09-11 Merck & Co., Inc. Process for preparing benzylpyruvic acids and esters
IT1232160B (it) * 1989-07-31 1992-01-25 Sigma Tau Ind Farmaceuti 2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono
DE4021108A1 (de) * 1990-07-03 1992-01-09 Bayer Ag Optisch aktive n-(alpha)-fluoracryloyl-aminosaeure-derivate, ihre herstellung, die daraus hergestellten optisch aktiven polymeren und deren verwendung zur spaltung von racematen
DE4123248C2 (de) * 1991-07-13 1996-03-07 Degussa Verfahren zur Herstellung von N-substituierten alpha-Aminosäuren und alpha-Aminosäure-Derivaten
US5977160A (en) * 1992-04-10 1999-11-02 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
KR20030046079A (ko) * 2001-12-05 2003-06-12 주식회사 코오롱 고순도 염산 델라프릴의 신규한 정제방법
JP4837557B2 (ja) * 2003-04-30 2011-12-14 ウェルスタット セラピューティクス コーポレイション 代謝障害の処置のための化合物
EA009646B1 (ru) * 2003-05-30 2008-02-28 Рэнбакси Лабораториз Лтд. Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa
JP2009514851A (ja) * 2005-11-08 2009-04-09 ランバクシー ラボラトリーズ リミテッド （３ｒ，５ｒ）−７−［２−（４−フルオロフェニル）−５−イソプロピル−３−フェニル−４−［（４−ヒドロキシメチルフェニルアミノ）カルボニル］−ピロール−１−イル］−３，５−ジヒドロキシ−ヘプタン酸ヘミカルシウム塩の製法
TW200744583A (en) * 2006-03-14 2007-12-16 Ranbaxy Lab Ltd Statin stabilizing dosage formulations
ITMI20061364A1 (it) * 2006-07-13 2008-01-14 Dipharma Spa Procedimento per la preparazione di delapril
BRPI0714361A2 (pt) * 2006-07-14 2013-03-26 Ranbaxy Lab Ltd polimorfo cristalino, composiÇço farmacÊutica contendo o mesmo, mÉtodo para sua preparaÇço e mÉtodo de tratamento
WO2014202659A1 (en) 2013-06-21 2014-12-24 Sanofi-Aventis Deutschland Gmbh Process for the preparation of amides of n-[1-(s)-(ethoxycarbonyl)-3-phenylpropyl]-l-alanine
US20240190809A1 (en) * 2021-05-11 2024-06-13 Awakn Ls Europe Holdings Limited Therapeutic aminoindane compounds and compositions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
FR2395998A1 (fr) * 1977-06-29 1979-01-26 Yoshitomi Pharmaceutical Nouveaux derives de la thiazolidine et leur application dans le traitement de l'hypertension
LU78804A1 (de) * 1977-12-30 1979-07-20 Byk Gulden Lomberg Chem Fab N-substituierte w-aminoalkanoyl-w-aminoalkansaeuren,ihre verwendung und verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
US4243678A (en) * 1977-12-30 1981-01-06 Byk Gulden Lomberg Chemische Fabrik Gmbh Acylhydrocarbylaminoalkanoic acids, compositions and uses
US4316896A (en) * 1978-09-07 1982-02-23 Merck & Co., Inc. Aminoacid derivatives as antihypertensives
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
DE3040021A1 (de) * 1980-10-23 1982-05-13 Windmöller & Hölscher, 4540 Lengerich Vorrichtung zum bilden und stapeln von von einer folienschlauchbahn abgetrennten abschnitten
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids

Also Published As

Publication number Publication date
ES506714A0 (es) 1983-06-01
IE812471L (en) 1982-04-30
MY8500500A (en) 1985-12-31
FI73698C (fi) 1987-11-09
IE51918B1 (en) 1987-04-29
PH18357A (en) 1985-06-05
US5098892A (en) 1992-03-24
ES8306710A1 (es) 1983-06-01
DK478181A (da) 1982-05-01
KR830007514A (ko) 1983-10-21
GR75368B (es) 1984-07-13
EP0051391B1 (en) 1984-09-05
NZ198826A (en) 1984-07-06
NO155133B (no) 1986-11-10
FI813383L (fi) 1982-05-01
PT73912B (en) 1983-01-25
FI73698B (fi) 1987-07-31
CA1287444C (en) 1991-08-06
DK164917B (da) 1992-09-07
KR880000890B1 (ko) 1988-05-30
ES524148A0 (es) 1985-05-01
AU7652181A (en) 1982-05-06
GB2086393B (en) 1984-01-11
ES515269A0 (es) 1983-12-01
HU183652B (en) 1984-05-28
PT73912A (en) 1981-11-01
DE3165862D1 (en) 1984-10-11
PH21390A (en) 1987-10-15
AU543804B2 (en) 1985-05-02
HK19887A (en) 1987-03-13
US4474692A (en) 1984-10-02
ES8504671A1 (es) 1985-05-01
US4822818A (en) 1989-04-18
GB2086393A (en) 1982-05-12
NO813662L (no) 1982-05-03
EP0051391A1 (en) 1982-05-12
NO155133C (no) 1987-02-18
DK164917C (da) 1993-02-01

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