ES8401496A1 - Cianoesteroides. - Google Patents

Cianoesteroides.

Info

Publication number
ES8401496A1
ES8401496A1 ES516372A ES516372A ES8401496A1 ES 8401496 A1 ES8401496 A1 ES 8401496A1 ES 516372 A ES516372 A ES 516372A ES 516372 A ES516372 A ES 516372A ES 8401496 A1 ES8401496 A1 ES 8401496A1
Authority
ES
Spain
Prior art keywords
compounds
pharmaceutical compositions
compositions containing
oxaestra
acetonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516372A
Other languages
English (en)
Other versions
ES516372A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES516372A0 publication Critical patent/ES516372A0/es
Publication of ES8401496A1 publication Critical patent/ES8401496A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE CIANOESTEROIDES DE FORMULA (I), EN LA QUE R1 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE UNA SAL SODICA DE FOSFONATO DE DIETILCIANOMETILENO CON UNA 19-NORANDROSTENO-3,17-DION A, CON EL GRUPO 3-CETONA PROTEGIDO, EN UN DISOLVENTE INERTE, TAL COMO TETRAHIDROFURANO O 1,2-DIMETOXIETANO, A LA TEMPERATURA DE REFLUJO DE LA MEZCLA REACCIONANTE; SEGUIDA DE LA SEPARACION DEL 7-CIANOMETILENO ESTEROIDE PROTEGIDO; Y SEPARACION DEL GRUPO PROTECTOR POR CALENTAMIENTO EN MEDIO ACUOALCONOLICO ACIDO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARAEL TRATAMIENTO DE HEMORRAGIA UTERINA FUNCIONAL, DISMENORREA Y ENDOMETRIOSIS.
ES516372A 1981-10-09 1982-10-08 Cianoesteroides. Expired ES8401496A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/310,204 US4389345A (en) 1981-10-09 1981-10-09 3-Oxoestra-17-acetonitrile and unsaturated analogs

Publications (2)

Publication Number Publication Date
ES516372A0 ES516372A0 (es) 1983-12-16
ES8401496A1 true ES8401496A1 (es) 1983-12-16

Family

ID=23201436

Family Applications (1)

Application Number Title Priority Date Filing Date
ES516372A Expired ES8401496A1 (es) 1981-10-09 1982-10-08 Cianoesteroides.

Country Status (9)

Country Link
US (1) US4389345A (es)
EP (1) EP0077040A1 (es)
JP (1) JPS5872600A (es)
AU (1) AU8923282A (es)
DK (1) DK446982A (es)
ES (1) ES8401496A1 (es)
NO (1) NO823374L (es)
PT (1) PT75664B (es)
ZA (1) ZA827381B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724174B1 (fr) * 1994-09-06 1997-01-17 Roussel Uclaf Procede de preparation d'un derive steroide 17beta-carboxy et nouveaux intermediaires
DE10043846A1 (de) * 2000-09-04 2002-04-04 Jenapharm Gmbh 17-Methylensteroide, Verfahren zu deren Herstellung und diese Verbindung enthaltende pharmazeutische Zusammensetzungen
WO2012116290A2 (en) * 2011-02-25 2012-08-30 Washington University Neuroactive 17(20)-z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
CN119192266A (zh) 2011-10-14 2024-12-27 萨奇治疗股份有限公司 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途
MX365644B (es) 2012-12-18 2019-06-10 Univ Washington Esteroides neuroactivos sustituidos con 19-alcoxi-17, profarmacos de los mismos, y metodos de tratamiento usando los mismos.
US9512170B2 (en) 2013-03-01 2016-12-06 Washington University Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors
US9365502B2 (en) 2013-03-11 2016-06-14 Washington University Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors
US9562026B2 (en) 2013-03-14 2017-02-07 Washington University Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
JP6470258B2 (ja) 2013-04-17 2019-02-13 セージ セラピューティクス， インコーポレイテッド １９−ノルｃ３，３−ジ置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法
ES2807264T3 (es) 2013-04-17 2021-02-22 Sage Therapeutics Inc Esteroides neuroactivos 19-nor para métodos de tratamiento
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
WO2015010054A2 (en) 2013-07-19 2015-01-22 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
ES2848823T3 (es) 2013-08-23 2021-08-12 Sage Therapeutics Inc Esteroides neuroactivos, composiciones y usos de los mismos
WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US10577390B2 (en) 2014-10-16 2020-03-03 Sage Therapeutics, Inc. Compositions and methods for treating CNS disorders
ME03809B (me) 2014-10-16 2021-04-20 Sage Therapeutics Inc KOMPOZICIJE I POSTUPCI ZA LEČENJE POREMEĆAJA CNS-a
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
WO2016123056A1 (en) 2015-01-26 2016-08-04 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP4155314A1 (en) 2015-02-20 2023-03-29 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
MA45599A (fr) 2016-07-11 2019-05-15 Sage Therapeutics Inc Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
US20190233465A1 (en) 2016-07-11 2019-08-01 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
CR20240234A (es) 2019-05-31 2024-07-09 Sage Therapeutics Inc ESTEROIDES NEUROACTIVOS Y COMPOSICIONES DE ESTOS (Divisional 2021-629)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2336438C2 (de) * 1973-07-14 1983-07-07 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 17 β- Oxalylsteroiden

Also Published As

Publication number Publication date
ES516372A0 (es) 1983-12-16
ZA827381B (en) 1983-11-30
US4389345A (en) 1983-06-21
PT75664A (en) 1982-11-01
JPS5872600A (ja) 1983-04-30
DK446982A (da) 1983-04-10
AU8923282A (en) 1983-04-14
PT75664B (en) 1985-01-11
EP0077040A1 (en) 1983-04-20
NO823374L (no) 1983-04-11

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