ES8401496A1 - Cianoesteroides. - Google Patents

Cianoesteroides.

Info

Publication number
ES8401496A1
ES8401496A1 ES516372A ES516372A ES8401496A1 ES 8401496 A1 ES8401496 A1 ES 8401496A1 ES 516372 A ES516372 A ES 516372A ES 516372 A ES516372 A ES 516372A ES 8401496 A1 ES8401496 A1 ES 8401496A1
Authority
ES
Spain
Prior art keywords
compounds
pharmaceutical compositions
compositions containing
oxaestra
acetonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516372A
Other languages
English (en)
Other versions
ES516372A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES516372A0 publication Critical patent/ES516372A0/es
Publication of ES8401496A1 publication Critical patent/ES8401496A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE CIANOESTEROIDES DE FORMULA (I), EN LA QUE R1 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE UNA SAL SODICA DE FOSFONATO DE DIETILCIANOMETILENO CON UNA 19-NORANDROSTENO-3,17-DION A, CON EL GRUPO 3-CETONA PROTEGIDO, EN UN DISOLVENTE INERTE, TAL COMO TETRAHIDROFURANO O 1,2-DIMETOXIETANO, A LA TEMPERATURA DE REFLUJO DE LA MEZCLA REACCIONANTE; SEGUIDA DE LA SEPARACION DEL 7-CIANOMETILENO ESTEROIDE PROTEGIDO; Y SEPARACION DEL GRUPO PROTECTOR POR CALENTAMIENTO EN MEDIO ACUOALCONOLICO ACIDO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARAEL TRATAMIENTO DE HEMORRAGIA UTERINA FUNCIONAL, DISMENORREA Y ENDOMETRIOSIS.
ES516372A 1981-10-09 1982-10-08 Cianoesteroides. Expired ES8401496A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/310,204 US4389345A (en) 1981-10-09 1981-10-09 3-Oxoestra-17-acetonitrile and unsaturated analogs

Publications (2)

Publication Number Publication Date
ES516372A0 ES516372A0 (es) 1983-12-16
ES8401496A1 true ES8401496A1 (es) 1983-12-16

Family

ID=23201436

Family Applications (1)

Application Number Title Priority Date Filing Date
ES516372A Expired ES8401496A1 (es) 1981-10-09 1982-10-08 Cianoesteroides.

Country Status (9)

Country Link
US (1) US4389345A (es)
EP (1) EP0077040A1 (es)
JP (1) JPS5872600A (es)
AU (1) AU8923282A (es)
DK (1) DK446982A (es)
ES (1) ES8401496A1 (es)
NO (1) NO823374L (es)
PT (1) PT75664B (es)
ZA (1) ZA827381B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724174B1 (fr) * 1994-09-06 1997-01-17 Roussel Uclaf Procede de preparation d'un derive steroide 17beta-carboxy et nouveaux intermediaires
DE10043846A1 (de) * 2000-09-04 2002-04-04 Jenapharm Gmbh 17-Methylensteroide, Verfahren zu deren Herstellung und diese Verbindung enthaltende pharmazeutische Zusammensetzungen
WO2012116290A2 (en) * 2011-02-25 2012-08-30 Washington University Neuroactive 17(20)-z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
CA3152410A1 (en) 2011-10-14 2013-04-18 Sage Therapeutics, Inc. 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders
TR201808616T4 (tr) 2012-12-18 2018-07-23 Sage Therapeutics Inc Nöroaktif 19-alkoksi-17-ikameli steroidler, bunların ön ilaçları ve bunları kullanan tedavi yöntemleri.
US9512170B2 (en) 2013-03-01 2016-12-06 Washington University Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors
US9365502B2 (en) 2013-03-11 2016-06-14 Washington University Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors
US9562026B2 (en) 2013-03-14 2017-02-07 Washington University Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
CN113527400B (zh) 2013-04-17 2024-06-28 萨奇治疗股份有限公司 19-去甲c3,3-二取代的c21-n-吡唑基类固醇及其使用方法
RU2019126333A (ru) 2013-04-17 2019-10-08 Сейдж Терапьютикс, Инк. 19-нор нейроактивные стероиды и способы их применения
WO2015010054A2 (en) 2013-07-19 2015-01-22 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
AU2014308621C1 (en) 2013-08-23 2022-01-06 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
MX2021004492A (es) 2014-10-16 2022-12-05 Sage Therapeutics Inc Composiciones para el tratamiento de trastornos del snc.
SMT202000414T1 (it) 2014-10-16 2020-09-10 Sage Therapeutics Inc Composizioni e metodi per trattare disturbi del snc
ME03749B (me) 2014-11-27 2021-04-20 Sage Therapeutics Inc KOMPOZICIJE I POSTUPCIZA LEČENJE POREMEĆAJA CNS-a
DK3250210T3 (da) 2015-01-26 2021-03-08 Sage Therapeutics Inc Sammensætninger og fremgangsmåder til behandling af cns-forstyrrelser
JP6875996B2 (ja) 2015-02-20 2021-05-26 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイド、組成物、およびその使用
WO2018013613A1 (en) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C17, c20, and c21 substituted neuroactive steroids and their methods of use
CA3030420C (en) 2016-07-11 2025-11-18 Sage Therapeutics, Inc. C7, C12 AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND ASSOCIATED METHODS OF USE
CN114206900A (zh) 2019-05-31 2022-03-18 萨奇治疗股份有限公司 神经活性类固醇及其组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2336438C2 (de) * 1973-07-14 1983-07-07 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 17 β- Oxalylsteroiden

Also Published As

Publication number Publication date
JPS5872600A (ja) 1983-04-30
ES516372A0 (es) 1983-12-16
PT75664B (en) 1985-01-11
ZA827381B (en) 1983-11-30
AU8923282A (en) 1983-04-14
NO823374L (no) 1983-04-11
EP0077040A1 (en) 1983-04-20
PT75664A (en) 1982-11-01
DK446982A (da) 1983-04-10
US4389345A (en) 1983-06-21

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