ES8401942A1 - Procedimiento para la preparacion de n-piridil-amidas de acido 1-fenil-ciclopentancarboxilico. - Google Patents

Procedimiento para la preparacion de n-piridil-amidas de acido 1-fenil-ciclopentancarboxilico.

Info

Publication number
ES8401942A1
ES8401942A1 ES518137A ES518137A ES8401942A1 ES 8401942 A1 ES8401942 A1 ES 8401942A1 ES 518137 A ES518137 A ES 518137A ES 518137 A ES518137 A ES 518137A ES 8401942 A1 ES8401942 A1 ES 8401942A1
Authority
ES
Spain
Prior art keywords
antiinflammatory
preparation
pharmaceutical compositions
new compounds
antitussive activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518137A
Other languages
English (en)
Other versions
ES518137A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medea Research SRL
Original Assignee
Medea Research SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT8125570A external-priority patent/IT1226048B/it
Priority claimed from IT24116/82A external-priority patent/IT1154522B/it
Application filed by Medea Research SRL filed Critical Medea Research SRL
Publication of ES8401942A1 publication Critical patent/ES8401942A1/es
Publication of ES518137A0 publication Critical patent/ES518137A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE N-PIRIDIL-AMIDAS DE ACIDO 1-FENIL-CICLOPENTACARBOXILICO, DE FORMULA (I), EN LA QUE PY ES EL ANILLO DE PIRIDINA, EVENTUALMENTE SUSTITUIDO POR UNO O MAS GRUPOS DE METILO O ATOMOS DE CLORO.CONSISTE EN HACER REACCIONAR DERIVADOS ACTIVADOS DE ACIDO 1-FENIL-CICLOPENTAN-CARBOXIL ICO, DE FORMULA GENERAL (II), CON AMINOPIRIDINAS, DE FORMULA (III), EN LAS QUE X ES UN ATOMO DE HALOGENO O UN GRUPO ALCOXILO: Y R Y RK, IGUALES O DIFERENTES, REPRESENTAN ATOMOS DE HIDROGENO, GRUPOS METILO O ATOMOS DE CLORO.DE APLICACION EN COMPOSICIONES FARMACEUTICAS POR SU ACTIVIDAD ANTIINFLAMATORIA.
ES518137A 1981-12-14 1982-12-13 Procedimiento para la preparacion de n-piridil-amidas de acido 1-fenil-ciclopentancarboxilico. Granted ES518137A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8125570A IT1226048B (it) 1981-12-14 1981-12-14 Composti ad attivita'antiinfiammatoria, processo per la loro preparazione e composizioni farmaceutiche relative
IT24116/82A IT1154522B (it) 1982-11-08 1982-11-08 Composti ad attivita' antiinfirmmatoria, processo per la loro preparazione e composizioni farmaceutiche relative

Publications (2)

Publication Number Publication Date
ES8401942A1 true ES8401942A1 (es) 1984-01-16
ES518137A0 ES518137A0 (es) 1984-01-16

Family

ID=26328463

Family Applications (1)

Application Number Title Priority Date Filing Date
ES518137A Granted ES518137A0 (es) 1981-12-14 1982-12-13 Procedimiento para la preparacion de n-piridil-amidas de acido 1-fenil-ciclopentancarboxilico.

Country Status (3)

Country Link
EP (1) EP0081756B1 (es)
DE (1) DE3263567D1 (es)
ES (1) ES518137A0 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1945632B1 (en) 2005-11-08 2013-09-18 Vertex Pharmaceuticals Incorporated Heterocyclic modulators of atp-binding cassette transporters
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
US8969386B2 (en) 2007-05-09 2015-03-03 Vertex Pharmaceuticals Incorporated Modulators of CFTR
SI2225230T1 (sl) 2007-12-07 2017-03-31 Vertex Pharmaceuticals Incorporated Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline
EP2639224B1 (en) 2007-12-07 2016-08-24 Vertex Pharmaceuticals Incorporated Process for producing cycloalkylcarboxiamido-pyridine benzoic acids
NZ720282A (en) 2008-02-28 2017-12-22 Vertex Pharma Heteroaryl derivatives as cftr modulators
AU2013270464B2 (en) * 2008-03-31 2016-05-26 Vertex Pharmaceuticals Incorporated Pyridyl derivatives as CFTR modulators
EP2271621B1 (en) * 2008-03-31 2013-11-20 Vertex Pharmaceuticals Incorporated Pyridyl derivatives as cftr modulators
HRP20211752T1 (hr) 2010-04-07 2022-02-18 Vertex Pharmaceuticals Incorporated Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena
WO2013112804A1 (en) 2012-01-25 2013-08-01 Vertex Pharmaceuticals Incorporated Formulations of 3-(6-(1-(2.2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
JP6963896B2 (ja) 2013-11-12 2021-11-10 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Ｃｆｔｒ媒介性疾患の処置のための医薬組成物を調製する方法
EP2878339A1 (en) 2013-12-02 2015-06-03 Siena Biotech S.p.A. SIP3 antagonists
PT3221692T (pt) 2014-11-18 2021-09-10 Vertex Pharma Processo de realização de testagem de alta produtividade por cromatografia líquida de alta eficiência

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584802A (es) * 1968-09-09 1970-01-02

Also Published As

Publication number Publication date
DE3263567D1 (en) 1985-06-20
EP0081756A1 (en) 1983-06-22
ES518137A0 (es) 1984-01-16
EP0081756B1 (en) 1985-05-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009