JPS5772981A - 1,8-naphthyridine derivative and its salt - Google Patents

1,8-naphthyridine derivative and its salt

Info

Publication number
JPS5772981A
JPS5772981A JP55148797A JP14879780A JPS5772981A JP S5772981 A JPS5772981 A JP S5772981A JP 55148797 A JP55148797 A JP 55148797A JP 14879780 A JP14879780 A JP 14879780A JP S5772981 A JPS5772981 A JP S5772981A
Authority
JP
Japan
Prior art keywords
lower alkyl
formula
salt
carboxylic acid
naphthyridine derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55148797A
Other languages
Japanese (ja)
Inventor
Junichi Matsumoto
Koshi Miyamoto
Hiroshi Egawa
Yoshiyuki Takase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP55148797A priority Critical patent/JPS5772981A/en
Publication of JPS5772981A publication Critical patent/JPS5772981A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NEW MATERIAL:A 1,8-naphthyridine derivative of formulaI(R1 is group of formula II or formula III; R4 is H or amino-protecting group, R5 is H or lower alkyl; R2 is lower alkyl; R3 is H or lower alkyl) and its salt.
EXAMPLE: 7-(4-Acetyl-1-piperazinyl)-1-ethyl-6-fluoro-1,2,3,4-tetrahydro-4-oxo-1,8- naphthyl-ridine-3-carboxylic acid ethyl ester.
USE: Intermediate for the preparation of antimicrobial agent.
PROCESS: The compond of formulaIis prepared by cyclizing the pyridine derivative of formula IV (R6 is lower alkyl) in the presence of a base such as sodium metal, in a solvent such as benzene, at 15W180°C. The starting raw material of formula IV is also a novel compound, and is obtained from known 3-fluro-2,6- dihydropyridine-5-carboxylic acid amide.
COPYRIGHT: (C)1982,JPO&Japio
JP55148797A 1980-10-22 1980-10-22 1,8-naphthyridine derivative and its salt Pending JPS5772981A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55148797A JPS5772981A (en) 1980-10-22 1980-10-22 1,8-naphthyridine derivative and its salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55148797A JPS5772981A (en) 1980-10-22 1980-10-22 1,8-naphthyridine derivative and its salt

Publications (1)

Publication Number Publication Date
JPS5772981A true JPS5772981A (en) 1982-05-07

Family

ID=15460913

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55148797A Pending JPS5772981A (en) 1980-10-22 1980-10-22 1,8-naphthyridine derivative and its salt

Country Status (1)

Country Link
JP (1) JPS5772981A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5967269A (en) * 1982-09-09 1984-04-16 ワ−ナ−−ランバ−ト・コンパニ− Antibacterial compound
WO1996023782A1 (en) * 1995-02-02 1996-08-08 Daiichi Pharmaceutical Co., Ltd. Heterocyclic compounds
WO1996024593A1 (en) * 1995-02-07 1996-08-15 Daiichi Pharmaceutical Co., Ltd. Heterocyclic spiro derivatives
WO2000006547A1 (en) * 1998-07-31 2000-02-10 Asahi Glass Company Ltd. Process for the preparation of 2,6-dichloronicotinonitriles

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50111080A (en) * 1974-02-13 1975-09-01
JPS5531042A (en) * 1978-08-25 1980-03-05 Dainippon Pharmaceut Co Ltd 1,8-naphthylidine derivative and its salt
JPS5583785A (en) * 1978-12-20 1980-06-24 Dainippon Pharmaceut Co Ltd 6-fluoro-1,8-naphthyridine derivative and its salt

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50111080A (en) * 1974-02-13 1975-09-01
JPS5531042A (en) * 1978-08-25 1980-03-05 Dainippon Pharmaceut Co Ltd 1,8-naphthylidine derivative and its salt
JPS5583785A (en) * 1978-12-20 1980-06-24 Dainippon Pharmaceut Co Ltd 6-fluoro-1,8-naphthyridine derivative and its salt

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5967269A (en) * 1982-09-09 1984-04-16 ワ−ナ−−ランバ−ト・コンパニ− Antibacterial compound
WO1996023782A1 (en) * 1995-02-02 1996-08-08 Daiichi Pharmaceutical Co., Ltd. Heterocyclic compounds
US5849757A (en) * 1995-02-02 1998-12-15 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives substituted by a bicyclic amino group as antibacterials
WO1996024593A1 (en) * 1995-02-07 1996-08-15 Daiichi Pharmaceutical Co., Ltd. Heterocyclic spiro derivatives
US6469023B1 (en) 1995-02-07 2002-10-22 Daiichi Pharmaceutical Co., Ltd. Heterocyclic spiro-derivative
EA003334B1 (en) * 1995-02-07 2003-04-24 Дайити Фармасьютикал Ко., Лтд. PYRIDONCARBONIC ACID DERIVATIVES AND ANTIBACTERIAL COMPOSITION ON THEIR BASIS
WO2000006547A1 (en) * 1998-07-31 2000-02-10 Asahi Glass Company Ltd. Process for the preparation of 2,6-dichloronicotinonitriles

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