ES8501759A1 - Procedimiento para preparar esteres de acidos imino-&-carboxilicos biciclicos opticamente puros - Google Patents
Procedimiento para preparar esteres de acidos imino-&-carboxilicos biciclicos opticamente purosInfo
- Publication number
- ES8501759A1 ES8501759A1 ES531284A ES531284A ES8501759A1 ES 8501759 A1 ES8501759 A1 ES 8501759A1 ES 531284 A ES531284 A ES 531284A ES 531284 A ES531284 A ES 531284A ES 8501759 A1 ES8501759 A1 ES 8501759A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- chain
- carbon atoms
- together form
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 101000740162 Homo sapiens Sodium- and chloride-dependent transporter XTRP3 Proteins 0.000 title 1
- -1 IMINO ACIDS Chemical class 0.000 title 1
- 102100037189 Sodium- and chloride-dependent transporter XTRP3 Human genes 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 6
- 150000007513 acids Chemical class 0.000 abstract 4
- IRZQDMYEJPNDEN-UHFFFAOYSA-N 2-azaniumyl-3-phenylbutanoate Chemical compound OC(=O)C(N)C(C)C1=CC=CC=C1 IRZQDMYEJPNDEN-UHFFFAOYSA-N 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 abstract 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
- VHVGNTVUSQUXPS-YUMQZZPRSA-N L-threo-3-phenylserine Chemical compound [O-]C(=O)[C@@H]([NH3+])[C@@H](O)C1=CC=CC=C1 VHVGNTVUSQUXPS-YUMQZZPRSA-N 0.000 abstract 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 2
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 2
- 230000008025 crystallization Effects 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 2
- 238000007127 saponification reaction Methods 0.000 abstract 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS IMINO-BAB-CARBOXILICOS BICICLICOS OPTICAMENTE PUROS, DE FORMULA (I) O (II), EN LAS QUE A, B, B, C, X, Y, Z, R Y R PUEDEN SER VARIOS RADICALES, Y R VALE 0 O 1.CONSISTE EN LA REACCION, EN PRESENCIA DE UN AGENTE CONDENSANTE, DE LOS COMPUESTOS OPTICAMENTE PUROS DE FORMULAS (III) Y (IV), CON COMPUESTOS OPTICAMENTE PUROS DE FORMULA (V), EN LAS QUE R PUEDE SER UNO DE VARIOS RADICALES Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LAS FORMULAS (I) Y (II).ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO HIPOTENSOR.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833303139 DE3303139A1 (de) | 1983-01-31 | 1983-01-31 | Verfahren zur herstellung von carboxyalkyldipeptiden |
| DE19833303112 DE3303112A1 (de) | 1983-01-31 | 1983-01-31 | Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES531284A0 ES531284A0 (es) | 1984-12-01 |
| ES8501759A1 true ES8501759A1 (es) | 1984-12-01 |
Family
ID=25807929
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES529272A Expired ES8500228A1 (es) | 1983-01-31 | 1984-01-30 | Procedimiento para desdoblar mezclas racemicas de esteres de acidos imino- -carboxilicos biciclicos |
| ES531284A Expired ES8501759A1 (es) | 1983-01-31 | 1984-04-04 | Procedimiento para preparar esteres de acidos imino-&-carboxilicos biciclicos opticamente puros |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES529272A Expired ES8500228A1 (es) | 1983-01-31 | 1984-01-30 | Procedimiento para desdoblar mezclas racemicas de esteres de acidos imino- -carboxilicos biciclicos |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0115345B1 (es) |
| JP (1) | JPH0788358B2 (es) |
| KR (1) | KR910001438B1 (es) |
| AU (1) | AU566589B2 (es) |
| CA (2) | CA1283249C (es) |
| DE (1) | DE3468415D1 (es) |
| DK (1) | DK174386B1 (es) |
| ES (2) | ES8500228A1 (es) |
| FI (1) | FI88153C (es) |
| GR (1) | GR82650B (es) |
| HU (1) | HU191120B (es) |
| IE (1) | IE56654B1 (es) |
| IL (1) | IL70830A (es) |
| MA (1) | MA20020A1 (es) |
| NO (1) | NO166641C (es) |
| NZ (1) | NZ206980A (es) |
| PT (1) | PT78036B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4500713A (en) * | 1982-09-23 | 1985-02-19 | Usv Pharmaceutical Corporation | Therapeutic dipeptides |
| DE3345355A1 (de) * | 1983-12-15 | 1985-06-27 | Hoechst Ag, 6230 Frankfurt | Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester |
| WO1986000896A1 (en) * | 1984-07-30 | 1986-02-13 | Schering Corporation | NOVEL PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA ADb BDPYRROLE-2-CARBOXYLATE |
| HU192914B (en) * | 1985-02-11 | 1987-07-28 | Richter Gedeon Vegyeszet | Process for producing new 3-/substituted amino/-5-phenyl-2/3h/-furanone derivatives and pharmaceutically acceptable salts |
| FR2620703B1 (fr) * | 1987-09-17 | 1991-10-04 | Adir | Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides |
| HU904967D0 (en) * | 1988-04-22 | 1991-01-28 | Hoechst Ag | Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives |
| US6407262B1 (en) | 2001-11-21 | 2002-06-18 | Brantford Chemicals Inc. | Process for the preparation of Ramipril |
| WO2006059347A2 (en) * | 2004-12-01 | 2006-06-08 | Morepen Laboratories Limited | Improved process for preparation of ramipril |
| CN102984945B (zh) | 2010-04-20 | 2014-08-20 | 凯瑞斯德生化(苏州)有限公司 | 一种环烯基在β位取代的丙氨酸的不对称合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| IE52663B1 (en) * | 1980-04-02 | 1988-01-20 | Warner Lambert Co | Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids |
| US4374847A (en) * | 1980-10-27 | 1983-02-22 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
-
1984
- 1984-01-25 HU HU84312A patent/HU191120B/hu unknown
- 1984-01-27 FI FI840350A patent/FI88153C/fi not_active IP Right Cessation
- 1984-01-27 DE DE8484100858T patent/DE3468415D1/de not_active Expired
- 1984-01-27 EP EP84100858A patent/EP0115345B1/de not_active Expired
- 1984-01-28 KR KR1019840000396A patent/KR910001438B1/ko not_active Expired
- 1984-01-30 NO NO840350A patent/NO166641C/no not_active IP Right Cessation
- 1984-01-30 NZ NZ206980A patent/NZ206980A/en unknown
- 1984-01-30 PT PT78036A patent/PT78036B/pt unknown
- 1984-01-30 CA CA000446349A patent/CA1283249C/en not_active Expired - Lifetime
- 1984-01-30 ES ES529272A patent/ES8500228A1/es not_active Expired
- 1984-01-30 MA MA20241A patent/MA20020A1/fr unknown
- 1984-01-30 IE IE210/84A patent/IE56654B1/en not_active IP Right Cessation
- 1984-01-30 IL IL70830A patent/IL70830A/xx not_active IP Right Cessation
- 1984-01-30 DK DK198400415A patent/DK174386B1/da not_active IP Right Cessation
- 1984-01-30 GR GR73651A patent/GR82650B/el unknown
- 1984-01-31 AU AU23933/84A patent/AU566589B2/en not_active Expired
- 1984-04-04 ES ES531284A patent/ES8501759A1/es not_active Expired
-
1988
- 1988-09-06 CA CA000576609A patent/CA1317067C/en not_active Expired - Lifetime
-
1991
- 1991-01-30 JP JP3027801A patent/JPH0788358B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL70830A (en) | 1988-02-29 |
| IL70830A0 (en) | 1984-04-30 |
| IE840210L (en) | 1984-07-31 |
| NO166641C (no) | 1991-08-21 |
| EP0115345B1 (de) | 1988-01-07 |
| HUT34159A (en) | 1985-02-28 |
| FI840350A7 (fi) | 1984-08-01 |
| ES531284A0 (es) | 1984-12-01 |
| ES529272A0 (es) | 1984-10-01 |
| NO166641B (no) | 1991-05-13 |
| DK41584D0 (da) | 1984-01-30 |
| NO840350L (no) | 1984-08-01 |
| DK41584A (da) | 1984-08-01 |
| ES8500228A1 (es) | 1984-10-01 |
| PT78036B (de) | 1986-05-30 |
| KR910001438B1 (ko) | 1991-03-07 |
| PT78036A (de) | 1984-02-01 |
| NZ206980A (en) | 1988-05-30 |
| AU2393384A (en) | 1984-08-02 |
| MA20020A1 (fr) | 1984-10-01 |
| CA1283249C (en) | 1991-04-16 |
| CA1317067C (en) | 1993-04-27 |
| DE3468415D1 (en) | 1988-02-11 |
| EP0115345A1 (de) | 1984-08-08 |
| DK174386B1 (da) | 2003-01-27 |
| JPH0517439A (ja) | 1993-01-26 |
| IE56654B1 (en) | 1991-10-23 |
| AU566589B2 (en) | 1987-10-22 |
| FI88153B (fi) | 1992-12-31 |
| FI840350A0 (fi) | 1984-01-27 |
| GR82650B (es) | 1985-02-07 |
| JPH0788358B2 (ja) | 1995-09-27 |
| HU191120B (en) | 1987-01-28 |
| FI88153C (fi) | 1993-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES452920A1 (es) | Procedimiento para preparar eteres de fenoles. | |
| EA200301193A1 (ru) | Оптическое разделение (1-бензил-4-метилпиперидин-3-ил)метиламина и его применение для получения производных пирроло 2,3-пиримидина в качестве ингибиторов протеинкиназы | |
| PT96890A (pt) | Processo para a preparacao de novos derivados com estrutura naftalenica e de composicoes farmaceuticas que os contem | |
| ES2005752A6 (es) | Un procedimiento asimetrico para la preparacion de 1-carbacefalosporinas. | |
| FI851318L (fi) | Optisesti aktiivisia alkyyliaryyliketaaleita ja menetelmä niiden valmistamiseksi | |
| ES8500228A1 (es) | Procedimiento para desdoblar mezclas racemicas de esteres de acidos imino- -carboxilicos biciclicos | |
| ATE52779T1 (de) | Zwischenverbindungen und verfahren fuer die herstellung von antibiotika. | |
| AR241019A2 (es) | "procedimiento para separar el grupo alilo de compuestos de carba-penem-carboxilatos de alilo para formar los correspondientes compuestos con el grupo carboxilo libre". | |
| ES8800667A1 (es) | Procedimiento para preparar acidos quinolina-3-carboxilicos con propiedades antibacteriales | |
| IL73822A (en) | Method of resolving bicyclic imino-carboxylic acid ester racemates,and novel intermediates therefor | |
| MX20639A (es) | Acidos aminoalquilfosfinicos substituidos con fosforo y procedimiento para su preparacion | |
| JPS5629551A (en) | Preparation of optically active threo-3- 3,4- dihydroxyphenyl serine | |
| DK182783D0 (da) | Fremgangsmade til fremstilling af 1-carboxy-(alkanoyl eller aralkanoyl)-indolin-2-carboxylsyreestere eller salte deraf | |
| ES499378A0 (es) | Procedimiento para la preparacion de nuevos benzoxazoles y benzotiazoles | |
| DK0625137T3 (da) | Fremgangsmåde til racematadskillelse af verapamil | |
| ES8506707A1 (es) | Un derivado de acido tiazolilacetico | |
| ATE19394T1 (de) | Verfahren zur herstellung von cyclopropancarbonsaeureesterderivaten. | |
| GB2069480B (en) | Process for the separation of the two optical isomers of moprolol and pharmaceutical compositions of the levorotatory antipode thereof | |
| ES8706705A1 (es) | Procedimiento para la resolucion optica de mezclas racemicas de acidos alfa-naftilpropionicos | |
| ES2009768B3 (es) | Procedimiento para preparar acido l-homoalanin-4-il (metil) fosfinicoasi como sus esteres alquilicos. | |
| PT79118A (de) | Cephalosporinderivate und verfahren zur ihrer herstellung | |
| ATE50558T1 (de) | Verfahren zur optischen auftrennung racemischer gemische von alpha-naphthylpropionsaeuren. | |
| ATE56697T1 (de) | Polymerisierbare verbindungen und verfahren zu ihrer herstellung. | |
| BG48694A3 (en) | Method for preparing alkandiol- dicarboxilates | |
| EA200000279A1 (ru) | Способ повышения оптической чистоты 2r-[1-гидрокси-1-трифторметил-3-циклопропилпропин-2-ил]-4-хлоранилина |