ES8501762A1 - Procedimiento para preparar nuevos derivados de piperidina - Google Patents

Procedimiento para preparar nuevos derivados de piperidina

Info

Publication number
ES8501762A1
ES8501762A1 ES525876A ES525876A ES8501762A1 ES 8501762 A1 ES8501762 A1 ES 8501762A1 ES 525876 A ES525876 A ES 525876A ES 525876 A ES525876 A ES 525876A ES 8501762 A1 ES8501762 A1 ES 8501762A1
Authority
ES
Spain
Prior art keywords
represent
formula
derivatives
alcohyl
piperidinoquinoxaline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525876A
Other languages
English (en)
Other versions
ES525876A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Publication of ES8501762A1 publication Critical patent/ES8501762A1/es
Publication of ES525876A0 publication Critical patent/ES525876A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE PIPERIDINA.CONSISTE EN HACER REACCIONAR UNA 4-AMINOQUINOXALINA DE FORMULA (II) CON UN DERIVADO DE PIPERIDINA DE FORMULA (III), PARA OBTENER NUEVOS DERIVADOS DE PIPERIDINAS DE FORMULA (I), EN FORMA DE BASES LIBRES Y DE SALES, POR ADICION DE ACIDO. DONDE: R1 Y R2 PUEDEN SER IGUALES O DIFERENTES, REPRESENTAN H, ALCOHILO DE C 1 A 8 Y OTROS Y REPRESENTAN UN COMUN, -(CH2)4 O -(CH2)5-; R3 Y R4 PUEDEN SER IGUALES O DIFERENTES, REPRESENTAN H, ALCOHILO DE C 1 A 4 Y OTROS Y REPRESENTAN EN COMUN -CH2- O -CH2-CH2-; X REPRESENTA CL, BR O ALCOHILO DE (1 A 4). LA REACCION SE REALIZA EN UN DISOLVENTE INERTE EN PRESENCIA DE AGENTES FIJADORES DE ACIDO, COMO CARBONATOS ALCALINOS, AMINAS Y OTROS Y A TEMPERATURA DE REFLUJO.
ES525876A 1982-09-25 1983-09-23 Procedimiento para preparar nuevos derivados de piperidina Granted ES525876A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823235565 DE3235565A1 (de) 1982-09-25 1982-09-25 Piperidinderivate, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
ES8501762A1 true ES8501762A1 (es) 1984-12-01
ES525876A0 ES525876A0 (es) 1984-12-01

Family

ID=6174159

Family Applications (4)

Application Number Title Priority Date Filing Date
ES525876A Granted ES525876A0 (es) 1982-09-25 1983-09-23 Procedimiento para preparar nuevos derivados de piperidina
ES534349A Granted ES534349A0 (es) 1982-09-25 1984-07-16 Procedimiento para preparar nuevos derivados de piperidina
ES534351A Granted ES534351A0 (es) 1982-09-25 1984-07-16 Procedimiento para preparar nuevos derivados de piperidina
ES534350A Granted ES534350A0 (es) 1982-09-25 1984-07-16 Procedimiento para preparar nuevos derivados de piperidina

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES534349A Granted ES534349A0 (es) 1982-09-25 1984-07-16 Procedimiento para preparar nuevos derivados de piperidina
ES534351A Granted ES534351A0 (es) 1982-09-25 1984-07-16 Procedimiento para preparar nuevos derivados de piperidina
ES534350A Granted ES534350A0 (es) 1982-09-25 1984-07-16 Procedimiento para preparar nuevos derivados de piperidina

Country Status (23)

Country Link
US (1) US4539323A (es)
EP (1) EP0104445A3 (es)
JP (1) JPS5978187A (es)
KR (1) KR840006222A (es)
AU (1) AU561118B2 (es)
CA (1) CA1215981A (es)
CS (1) CS235342B2 (es)
DD (1) DD212517A5 (es)
DE (1) DE3235565A1 (es)
DK (1) DK436583A (es)
ES (4) ES525876A0 (es)
FI (1) FI833292A7 (es)
GR (1) GR78973B (es)
HU (1) HU191637B (es)
IL (1) IL69777A (es)
NO (1) NO833423L (es)
NZ (1) NZ205716A (es)
PH (1) PH20015A (es)
PL (1) PL139590B1 (es)
PT (1) PT77380B (es)
SU (1) SU1187720A3 (es)
YU (1) YU192183A (es)
ZA (1) ZA837081B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4601897A (en) * 1985-11-06 1986-07-22 Pfizer Inc. Prazosin-pirbuterol combination for bronchodilation
JPS62212385A (ja) * 1986-03-13 1987-09-18 Kotobuki Seiyaku Kk キナゾリン誘導体並びに血圧降下剤及びその製法
EP1317258B1 (en) * 2000-06-28 2009-02-11 Merck & Co., Inc. Use of allopurinol for the treatment of hypertension
CA2490764C (en) 2002-07-01 2011-11-22 Tibotec Pharmaceuticals Ltd. New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance
FR2854633B1 (fr) * 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
FR2866885B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009465A1 (de) * 1978-09-20 1980-04-02 Ciba-Geigy Ag N-(1-(4-Amino-2-chinazolinyl)-3- oder -4-piperidyl-lactame, Verfahren zu ihrer Herstellung, sowie pharmazeutische Präparate enthaltend diese Verbindungen
US4309541A (en) * 1978-09-20 1982-01-05 Ciba-Geigy Corporation Piperidinyl-lactams
FR2483920A1 (fr) * 1980-06-09 1981-12-11 Synthelabo Nouveaux derives de quinazoline, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
EP0104445A3 (de) 1985-07-10
ES8504182A1 (es) 1985-04-01
NO833423L (no) 1984-03-26
PH20015A (en) 1986-08-28
ZA837081B (en) 1985-05-29
SU1187720A3 (ru) 1985-10-23
PT77380B (de) 1986-03-20
KR840006222A (ko) 1984-11-22
FI833292L (fi) 1984-03-26
ES534351A0 (es) 1985-04-01
DK436583D0 (da) 1983-09-23
DD212517A5 (de) 1984-08-15
ES8504181A1 (es) 1985-04-01
ES8504180A1 (es) 1985-04-01
FI833292A7 (fi) 1984-03-26
HU191637B (en) 1987-03-30
YU192183A (es) 1986-12-31
CA1215981A (en) 1986-12-30
PL243878A1 (en) 1985-01-02
NZ205716A (en) 1985-08-30
JPS5978187A (ja) 1984-05-04
AU561118B2 (en) 1987-04-30
AU1939683A (en) 1984-03-29
ES534349A0 (es) 1985-04-01
US4539323A (en) 1985-09-03
PL139590B1 (en) 1987-02-28
DK436583A (da) 1984-03-26
ES525876A0 (es) 1984-12-01
EP0104445A2 (de) 1984-04-04
GR78973B (es) 1984-10-02
PT77380A (de) 1983-10-01
IL69777A (en) 1986-09-30
CS235342B2 (en) 1985-05-15
ES534350A0 (es) 1985-04-01
FI833292A0 (fi) 1983-09-15
DE3235565A1 (de) 1984-03-29

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