ES480053A1 - Un procedimiento para la preparacion de nuevos derivados de quinazolina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de quinazolina.

Info

Publication number
ES480053A1
ES480053A1 ES480053A ES480053A ES480053A1 ES 480053 A1 ES480053 A1 ES 480053A1 ES 480053 A ES480053 A ES 480053A ES 480053 A ES480053 A ES 480053A ES 480053 A1 ES480053 A1 ES 480053A1
Authority
ES
Spain
Prior art keywords
formula
lower alkyl
hydrogen
quinazoline
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480053A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Publication of ES480053A1 publication Critical patent/ES480053A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados de quinazolina de fórmula: **(Formula-01)** donde R es un grupo alquilo inferior; Y es un grupo de fórmula - (CHR1)m-Z, donde R1 es un átomo de hidrógeno o un grupo alquilo inferior, m es 1 o 2 con la condición de que cuando m es 2, los grupos R1 pueden ser iguales o diferentes y Z es un grupo de fórmula -N(R2)CONHR5 o -OCNHR5, donde R2 es un átomo de higrógeno o un grupo alquilo inferior y R5 es hidrógeno, alquilo inferior, bencilo o fenilo; cuyo procedimiento se caracteriza por hacer reaccionar una quinazolina de fórmula: **(Fórmula- 02)** donde R, R1, R2 y m son los definidos anteriormente, con un isocianato de fórmula R5NCO, donde R5 es el definido anteriormente pero distinto de hidrógeno, o, para preparar compuestos donde R5 es hidrógeno, con cianato sódico o potásico en presencia de un ácido; opcionalmente seguido de conversión del producto de fórmula (I) es una sal de adición de ácido farmacéuticamente aceptable por reacción con un ácido no tóxico.
ES480053A 1977-11-03 1979-04-27 Un procedimiento para la preparacion de nuevos derivados de quinazolina. Expired ES480053A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4566977 1977-11-03

Publications (1)

Publication Number Publication Date
ES480053A1 true ES480053A1 (es) 1980-07-16

Family

ID=10438111

Family Applications (2)

Application Number Title Priority Date Filing Date
ES474763A Expired ES474763A1 (es) 1977-11-03 1978-11-02 Un procedimiento para la preparacion de nuevos derivados de quinazolona.
ES480053A Expired ES480053A1 (es) 1977-11-03 1979-04-27 Un procedimiento para la preparacion de nuevos derivados de quinazolina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES474763A Expired ES474763A1 (es) 1977-11-03 1978-11-02 Un procedimiento para la preparacion de nuevos derivados de quinazolona.

Country Status (24)

Country Link
US (1) US4188391A (es)
JP (1) JPS5498786A (es)
AR (2) AR221851A1 (es)
AT (1) AT366043B (es)
AU (1) AU506317B2 (es)
BE (1) BE871769A (es)
CA (1) CA1086735A (es)
CH (1) CH637130A5 (es)
DE (1) DE2847622A1 (es)
DK (1) DK488078A (es)
ES (2) ES474763A1 (es)
FI (1) FI63934C (es)
FR (1) FR2407926A1 (es)
HK (1) HK94184A (es)
IE (1) IE47996B1 (es)
IL (1) IL55845A (es)
IT (1) IT1101287B (es)
KE (1) KE3351A (es)
LU (1) LU80461A1 (es)
MY (1) MY8500284A (es)
NL (1) NL174144C (es)
PH (1) PH14693A (es)
PT (1) PT68733A (es)
SE (1) SE7811323L (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489075A (en) * 1982-05-15 1984-12-18 Pfizer Inc. Cyclic sulfonamidoalkyl substituted 4-piperidinoquinazoline cardiac stimulants
JPS61215389A (ja) * 1985-03-20 1986-09-25 Kyowa Hakko Kogyo Co Ltd キナゾリン誘導体およびそれを含有する強心剤
US5614627A (en) * 1993-09-10 1997-03-25 Eisai Co., Ltd. Quinazoline compounds
EP0934941A1 (en) * 1996-08-09 1999-08-11 Eisai Co., Ltd. Benzopiperidine derivatives
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
EP1991212A1 (en) * 2006-03-08 2008-11-19 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2068872A1 (en) * 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
AU2007299920A1 (en) * 2006-09-19 2008-03-27 Braincells, Inc. PPAR Mediated Modulation of Neurogenesis
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
CN101522662A (zh) * 2006-10-06 2009-09-02 博士伦公司 喹诺酮羧酸、其衍生物、及其制备方法和其用作抗菌剂的用途
US7632944B2 (en) * 2007-01-24 2009-12-15 Bausch & Lomb Incorporated Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US11407729B2 (en) * 2019-03-19 2022-08-09 Stingray Therapeutics, Inc. Quinoline and quinazoline compounds and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1199768A (en) * 1966-10-31 1970-07-22 Pfizer & Co C Nitrogen Heterocycles and process for their preparation
US3812127A (en) * 1966-10-31 1974-05-21 Pfizer 4-(quinolin-4-yl)piperazine-1-carboxylic acid esters
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
GB1460389A (en) * 1974-07-25 1977-01-06 Pfizer Ltd 4-substituted quinazoline cardiac stimulants

Also Published As

Publication number Publication date
PH14693A (en) 1981-11-10
DE2847622A1 (de) 1979-05-31
CH637130A5 (de) 1983-07-15
CA1086735A (en) 1980-09-30
IE47996B1 (en) 1984-08-22
ATA783878A (de) 1981-07-15
AU506317B2 (en) 1979-12-20
JPS5498786A (en) 1979-08-03
KE3351A (en) 1983-12-16
AR221251A1 (es) 1981-01-15
NL174144B (nl) 1983-12-01
AT366043B (de) 1982-03-10
NL174144C (nl) 1984-05-01
FI63934C (fi) 1983-09-12
FI63934B (fi) 1983-05-31
FR2407926A1 (fr) 1979-06-01
AU4127778A (en) 1979-05-17
JPS566428B2 (es) 1981-02-10
ES474763A1 (es) 1980-12-16
US4188391A (en) 1980-02-12
DK488078A (da) 1979-05-04
HK94184A (en) 1984-12-07
IL55845A0 (en) 1979-01-31
IT1101287B (it) 1985-09-28
MY8500284A (en) 1985-12-31
PT68733A (en) 1978-12-01
FI783325A7 (fi) 1979-05-04
SE7811323L (sv) 1979-05-04
AR221851A1 (es) 1981-03-31
LU80461A1 (fr) 1980-05-07
FR2407926B1 (es) 1982-11-12
BE871769A (fr) 1979-05-03
NL7810865A (nl) 1979-05-07
IT7829368A0 (it) 1978-11-02
IL55845A (en) 1982-07-30

Similar Documents

Publication Publication Date Title
ES480053A1 (es) Un procedimiento para la preparacion de nuevos derivados de quinazolina.
ES473074A1 (es) Un procedimiento para la preparacion de derivados de tieno- tiacina
ES483767A1 (es) Procedimiento para producir n-arilsulfonil-l-argininamidas
ES472742A1 (es) Procedimiento para la obtencion de derivados de alqueno
ES2112332T3 (es) Derivados de substitucion de oxigeno de productos de adicion de nucleofilo-oxido nitrico utilizados como promedicamentos donadores de oxido nitrico.
ES8800132A1 (es) Un procedimiento para la produccion de compuestos de fenetanolamina
ES485274A1 (es) Un procedimiento para la preparacion de derivados de fenil- piperacina
ES479991A1 (es) Un procedimiento para la preparacion de ftalazinas.
ES8504738A1 (es) Procedimiento para la obtencion de nuevos derivados de mercaptoimidazol
ES2069281T3 (es) Derivado de fenantreno.
ES8607912A1 (es) Un derivado de fenilserina
ES8607299A1 (es) Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas
ES8704153A1 (es) Un procedimiento para preparar derivados de pirimidina
ATE13765T1 (de) 2-(1,4-benzodioxan-2-ylalkyl)-imidazole, deren herstellung und sie enthaltende pharmazeutische mittel.
ES480671A1 (es) Un procedimiento para la preparacion de nuevos derivados de quinazolina.
ES463971A1 (es) Perfeccionamientos en o relacionados con compuestos organi- cos.
ES8600240A1 (es) Metodo para preparar derivados de fenilindeno
ES483003A1 (es) Procedimiento de preparacion de derivados de fenil-1-pipera-zina
SE7704829L (sv) Indazolyl-(4)-oxi-propanolaminer
ES470916A1 (es) Ÿun procedimiento para la preparacion de derivados de acidos4-hidroxi-2-quinolinon-3-carboxilicosŸ
ES8202818A1 (es) Un procedimiento para preparar derivados de tetrazolilcuma- rina
ES8205215A1 (es) Un procedimiento para la preparacion de nuevos derivados del acido acetico.
ES448629A1 (es) Procedimiento para la preparacion de nuevos derivados de 1,4-bis-(carboxil-alcohil-benzoxazolil)-naftaleno.
ES8601138A1 (es) Un procedimiento para preparar derivados de 5-(piridinil o fenil)-2(1h)-piridinona
SE7613193L (sv) Framstellning av tetrahydropyridin- och piperidinderivat