ES8504661A1 - Procedimiento de preparacion de fenilpiruvato de sodio cristalizado monohidratado - Google Patents
Procedimiento de preparacion de fenilpiruvato de sodio cristalizado monohidratadoInfo
- Publication number
- ES8504661A1 ES8504661A1 ES534381A ES534381A ES8504661A1 ES 8504661 A1 ES8504661 A1 ES 8504661A1 ES 534381 A ES534381 A ES 534381A ES 534381 A ES534381 A ES 534381A ES 8504661 A1 ES8504661 A1 ES 8504661A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- crystalline sodium
- sodium phenylpyruvate
- monohydrate
- hot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ABWVLWHPVBHFLQ-UHFFFAOYSA-M sodium;2-oxo-3-phenylpropanoate;hydrate Chemical compound O.[Na+].[O-]C(=O)C(=O)CC1=CC=CC=C1 ABWVLWHPVBHFLQ-UHFFFAOYSA-M 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
- 239000001903 2-oxo-3-phenylpropanoic acid Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 abstract 1
- 229940091173 hydantoin Drugs 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- MQGYVGKMCRDEAF-UHFFFAOYSA-M sodium;2-oxo-3-phenylpropanoate Chemical compound [Na+].[O-]C(=O)C(=O)CC1=CC=CC=C1 MQGYVGKMCRDEAF-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO DE FABRICACION DEL FENILPIRUVATO SODICO CRISTALIZADO MONOHIDRATADO.SE HACE REACCIONAR, EN CALIENTE, EN MEDIO ACUOSO EN PRESENCIA DE UNA CANTIDAD CATALITICA DE ETANOLAMINA, EL BENZALDEHIDO CON LA CANTIDAD ESTEQUIOMETRICA DE HIDANTOINA, SE TRATA SEGUIDAMENTE EL MEDIO DE REACCION EN CALIENTE, A PH F 14 CON UN EXCESO DE SOSA Y, DESPUES SE ACIDIFICA HASTA PH F 9, CON ACIDO CLORHIDRICO CONTRADO, LA SOLUCION ASI OBTENIDA, Y SE SEPARA EL PRECIPITADO FORMADO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8311792A FR2549469B1 (fr) | 1983-07-18 | 1983-07-18 | Procede de preparation du phenylpyruvate de sodium monohydrate cristallise |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8504661A1 true ES8504661A1 (es) | 1985-04-16 |
| ES534381A0 ES534381A0 (es) | 1985-04-16 |
Family
ID=9290851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES534381A Granted ES534381A0 (es) | 1983-07-18 | 1984-07-17 | Procedimiento de preparacion de fenilpiruvato de sodio cristalizado monohidratado |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4518800A (es) |
| EP (1) | EP0132201B1 (es) |
| JP (1) | JPS6038344A (es) |
| AT (1) | ATE23035T1 (es) |
| CA (1) | CA1223885A (es) |
| DE (1) | DE3461029D1 (es) |
| ES (1) | ES534381A0 (es) |
| FR (1) | FR2549469B1 (es) |
| SG (1) | SG27387G (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912255A (en) * | 1989-04-13 | 1990-03-27 | Chan Albert S | Process for preparing sodium phenylpyruvate from calcium phenylpyruvate |
| US5360927A (en) * | 1994-01-24 | 1994-11-01 | Development Center For Biotechnology | Process for the preparation of monohydrated sodium phenylpyruvate |
| WO2003014057A1 (en) * | 2001-08-08 | 2003-02-20 | Tanabe Seiyaku Co., Ltd. | Processes for producing halogenophenylpyruvic acid and optically active halogenophenylalanine |
| CN107033089B (zh) * | 2017-04-28 | 2019-06-21 | 浙江昂利泰制药有限公司 | 一种α-酮苯丙氨酸钙的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3254109A (en) * | 1963-08-13 | 1966-05-31 | Gulf Research Development Co | Nitrate esters of aldehyde cyanohydrins |
| US3412116A (en) * | 1965-11-01 | 1968-11-19 | Akad Wissenschaften Ddr | Method of producing gamma-keto acids |
| JPS5227147B1 (es) * | 1971-06-16 | 1977-07-19 | ||
| GB1521904A (en) * | 1974-07-27 | 1978-08-16 | Nisshin Flour Milling Co | 3-methyl-3-(substituted aryl)-pyruvic acids and a process of preparing them and their lower alkyl esters |
| ES496382A0 (es) * | 1979-10-31 | 1982-03-01 | Byk Gulden Lomberg Chem Fab | Procedimiento para la preparacion de acidos oxocarboxilicos sustituidos |
-
1983
- 1983-07-18 FR FR8311792A patent/FR2549469B1/fr not_active Expired
-
1984
- 1984-07-06 CA CA000458352A patent/CA1223885A/en not_active Expired
- 1984-07-12 EP EP84401484A patent/EP0132201B1/fr not_active Expired
- 1984-07-12 DE DE8484401484T patent/DE3461029D1/de not_active Expired
- 1984-07-12 AT AT84401484T patent/ATE23035T1/de not_active IP Right Cessation
- 1984-07-13 US US06/630,427 patent/US4518800A/en not_active Expired - Fee Related
- 1984-07-16 JP JP59147425A patent/JPS6038344A/ja active Pending
- 1984-07-17 ES ES534381A patent/ES534381A0/es active Granted
-
1987
- 1987-03-18 SG SG273/87A patent/SG27387G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG27387G (en) | 1988-09-23 |
| FR2549469A1 (fr) | 1985-01-25 |
| JPS6038344A (ja) | 1985-02-27 |
| EP0132201A3 (en) | 1985-03-06 |
| CA1223885A (en) | 1987-07-07 |
| DE3461029D1 (en) | 1986-11-27 |
| ES534381A0 (es) | 1985-04-16 |
| FR2549469B1 (fr) | 1985-11-08 |
| ATE23035T1 (de) | 1986-11-15 |
| EP0132201B1 (fr) | 1986-10-22 |
| US4518800A (en) | 1985-05-21 |
| EP0132201A2 (fr) | 1985-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970203 |