ES8504814A1 - Un procedimiento para preparar una b-lactama - Google Patents

Un procedimiento para preparar una b-lactama

Info

Publication number
ES8504814A1
ES8504814A1 ES526282A ES526282A ES8504814A1 ES 8504814 A1 ES8504814 A1 ES 8504814A1 ES 526282 A ES526282 A ES 526282A ES 526282 A ES526282 A ES 526282A ES 8504814 A1 ES8504814 A1 ES 8504814A1
Authority
ES
Spain
Prior art keywords
formula
product
iii
hydrogen
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526282A
Other languages
English (en)
Other versions
ES526282A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES8504814A1 publication Critical patent/ES8504814A1/es
Publication of ES526282A0 publication Critical patent/ES526282A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UNA BETA-LACTAMA DE FORMULA GENERAL (I) O UNA SAL O UN ESTER DE LA MISMA, EN LA QUE R1 ES ACILO, HIDROGENO O UN GRUPO PROTECTOR DE AMINO.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE CICLIZA UN COMPUESTO DE FORMULA (II) PARA OBTENER UN PRODUCTO DE FORMULA (III), EN LA QUE R2 ES HIDROGENO; SEGUNDA, SE METOXILA EL PRODUCTO DE FORMULA (III) POR TRATAMIENTO CON UN AGENTE HALOGENANTE Y UN AGENTE METOXILANTE, PARA FORMAR UN PRODUCTO DE FORMULA (III), EN LA QUE R2 ES METOXILO; Y POR ULTIMO, SE SEPARA EL GRUPO PROTECTOR DE AMINO, PARA FORMAR UN PRODUCTO EN EL QUE R1 ES HIDROGENO.DE APLICACION COMO AGENTES PARA COMBATIR INFECCIONES BACTERIANAS.
ES526282A 1982-10-06 1983-10-06 Un procedimiento para preparar una b-lactama Granted ES526282A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43317582A 1982-10-06 1982-10-06

Publications (2)

Publication Number Publication Date
ES8504814A1 true ES8504814A1 (es) 1985-04-16
ES526282A0 ES526282A0 (es) 1985-04-16

Family

ID=23719123

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526282A Granted ES526282A0 (es) 1982-10-06 1983-10-06 Un procedimiento para preparar una b-lactama

Country Status (27)

Country Link
JP (1) JPS5988462A (es)
KR (1) KR900005132B1 (es)
AU (1) AU568312B2 (es)
BE (1) BE897883A (es)
CA (1) CA1253501A (es)
CH (1) CH658858A5 (es)
DD (1) DD222016A5 (es)
DE (1) DE3336262A1 (es)
DK (1) DK457983A (es)
ES (1) ES526282A0 (es)
FI (1) FI833631A7 (es)
FR (1) FR2534253B1 (es)
GB (1) GB2129428B (es)
GR (1) GR79704B (es)
HU (1) HU190507B (es)
IE (1) IE56600B1 (es)
IL (1) IL69917A (es)
IT (1) IT1171722B (es)
LU (1) LU85033A1 (es)
NL (1) NL8303410A (es)
NO (1) NO833626L (es)
NZ (1) NZ205642A (es)
PH (1) PH24175A (es)
PT (1) PT77458B (es)
SE (1) SE8305509L (es)
SU (1) SU1318146A3 (es)
ZA (1) ZA837491B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0135194A1 (en) * 1983-09-16 1985-03-27 Takeda Chemical Industries, Ltd. Azetidinones and their production
WO1985004876A1 (fr) * 1984-04-24 1985-11-07 Takeda Chemical Industries, Ltd. Derives de 2-azetidinone et leur procede de preparation
US4581170A (en) * 1984-08-03 1986-04-08 E. R. Squibb & Sons, Inc. N-hydroxyl protecting groups and process and intermediates for the preparation of 3-acylamino-1-hydroxy-2-azetidinones
EP0171064B1 (en) * 1984-08-06 1995-07-12 Fujisawa Pharmaceutical Co., Ltd. Azetidinone derivative and processes for production thereof
UY34585A (es) 2012-01-24 2013-09-02 Aicuris Gmbh & Co Kg Compuestos b-lactámicos sustituidos con amidina, su preparación y uso

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337197A (en) * 1980-10-31 1982-06-29 E. R. Squibb & Sons, Inc. O-sulfated β-lactam hydroxamic acids and intermediates

Also Published As

Publication number Publication date
AU1993983A (en) 1984-04-12
SE8305509D0 (sv) 1983-10-06
FI833631A0 (fi) 1983-10-06
KR900005132B1 (ko) 1990-07-20
DE3336262A1 (de) 1984-04-12
FI833631A7 (fi) 1984-04-07
CA1253501A (en) 1989-05-02
SU1318146A3 (ru) 1987-06-15
DK457983D0 (da) 1983-10-04
IL69917A (en) 1987-10-20
NO833626L (no) 1984-04-09
GR79704B (es) 1984-10-31
GB2129428B (en) 1986-03-19
GB8326626D0 (en) 1983-11-09
AU568312B2 (en) 1987-12-24
IE56600B1 (en) 1991-10-09
JPS5988462A (ja) 1984-05-22
SE8305509L (sv) 1984-04-07
IE832354L (en) 1984-04-06
PT77458B (en) 1986-02-26
PH24175A (en) 1990-03-22
DK457983A (da) 1984-04-07
CH658858A5 (fr) 1986-12-15
FR2534253A1 (fr) 1984-04-13
IT1171722B (it) 1987-06-10
BE897883A (fr) 1984-03-30
HU190507B (en) 1986-09-29
DD222016A5 (de) 1985-05-08
GB2129428A (en) 1984-05-16
NL8303410A (nl) 1984-05-01
FR2534253B1 (fr) 1985-07-26
KR840006337A (ko) 1984-11-29
PT77458A (en) 1983-11-01
IT8323172A0 (it) 1983-10-06
ES526282A0 (es) 1985-04-16
ZA837491B (en) 1984-06-27
IL69917A0 (en) 1984-01-31
LU85033A1 (fr) 1984-05-10
NZ205642A (en) 1986-08-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401