ES8506025A1 - Un procedimiento para preparar derivados de cefem - Google Patents

Un procedimiento para preparar derivados de cefem

Info

Publication number
ES8506025A1
ES8506025A1 ES528003A ES528003A ES8506025A1 ES 8506025 A1 ES8506025 A1 ES 8506025A1 ES 528003 A ES528003 A ES 528003A ES 528003 A ES528003 A ES 528003A ES 8506025 A1 ES8506025 A1 ES 8506025A1
Authority
ES
Spain
Prior art keywords
carboxymethoxyphenylacetamido
substituted
same
alkanoyloxy
preparations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528003A
Other languages
English (en)
Other versions
ES528003A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP21772682A external-priority patent/JPS59108791A/ja
Priority claimed from JP3601783A external-priority patent/JPS59161389A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ES8506025A1 publication Critical patent/ES8506025A1/es
Publication of ES528003A0 publication Critical patent/ES528003A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE CEFEM.CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) O DE UNA DE SUS SALES CON UN GRUPO HETEROCICLO-TIOL QUE CONTIENE NITROGENO SUSTITUIDO O NO SUSTITUIDO, EN UN DISOLVENTE COMO AGUA, EN PRESENCIA DE UN HIDROGENOCARBONATO DE SODIO Y A UNA TEMPERATURA ENTRE 50 Y 70JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) O SU SAL FARMACEUTICAMENTE ACEPTABLE. SIENDO; R1, HIDROXI, ALCANOILOXI DE C 1 A 4 Y OTROS; R2, H O METOXI; A UN GRUPO DE FORMULA (III) O (IV); R4, H O ALQUILO DE C 1 A 4; RK3 ALCANOILOXI DE C 1 A 4, Y RL3 UN GRUPO HETEROCICLO-TIOL QUE CONTIENE NITROGENO SUSTITUIDO O NO SUSTITUIDO.SE UTILIZAN COMO AGENTES ANTIBACTERIANOS CONTRA LAS BACTERIAS GRAM (B) Y GRAM (C).
ES528003A 1982-12-14 1983-12-13 Un procedimiento para preparar derivados de cefem Granted ES528003A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21772682A JPS59108791A (ja) 1982-12-14 1982-12-14 ７−カルボキシメトキシフエニルアセトアミド−３−セフエム誘導体、その製造方法およびそれからなる抗菌剤
JP3601783A JPS59161389A (ja) 1983-03-07 1983-03-07 ７−カルボキシメトキシフエニルアセトアミドセフエム誘導体，その製造法およびそれからなる抗菌剤

Publications (2)

Publication Number Publication Date
ES8506025A1 true ES8506025A1 (es) 1985-06-16
ES528003A0 ES528003A0 (es) 1985-06-16

Family

ID=26375029

Family Applications (2)

Application Number Title Priority Date Filing Date
ES528003A Granted ES528003A0 (es) 1982-12-14 1983-12-13 Un procedimiento para preparar derivados de cefem
ES534297A Expired ES8505691A1 (es) 1982-12-14 1984-07-13 Un procedimiento para preparar derivados de cefem

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES534297A Expired ES8505691A1 (es) 1982-12-14 1984-07-13 Un procedimiento para preparar derivados de cefem

Country Status (16)

Country Link
US (1) US4546176A (es)
KR (1) KR840007012A (es)
AT (1) ATA435283A (es)
AU (1) AU2082783A (es)
BE (1) BE898442A (es)
CH (1) CH656131A5 (es)
DE (1) DE3345093A1 (es)
DK (1) DK572183A (es)
ES (2) ES528003A0 (es)
FR (1) FR2569195B1 (es)
GB (1) GB2132613B (es)
IT (1) IT1169969B (es)
NL (1) NL8304272A (es)
PH (1) PH20168A (es)
SE (1) SE8306882L (es)
YU (1) YU237283A (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232918A (en) * 1987-07-23 1993-08-03 Imperial Chemical Industries Plc Cephalosporin derivatives
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5273973A (en) * 1988-10-24 1993-12-28 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl esters
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
EP0366189A3 (en) * 1988-10-24 1992-01-02 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial lactam-quinolones
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
ES2147721T3 (es) * 1990-04-18 2000-10-01 Procter & Gamble Pharma Quinolonil lactamas antimicrobianas.
US5244892A (en) * 1990-10-16 1993-09-14 Kyorin Pharmaceutical Co., Ltd. Cephem compounds, and antibacterial agents
CA2196539C (en) * 1994-08-02 2001-05-15 The Procter & Gamble Company Process for making quinolonyl lactam antimicrobials and novel intermediate compounds
WO1996004247A1 (en) * 1994-08-02 1996-02-15 The Procter & Gamble Company Process for making antimicrobial compounds
TW200420573A (en) * 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
AU2004217919A1 (en) * 2003-03-05 2004-09-16 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using the same
WO2005042554A1 (en) * 2003-10-30 2005-05-12 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
US20070270357A1 (en) * 2003-11-18 2007-11-22 Farmer Jay J Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same
EP1723159B1 (en) * 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208171A1 (es) * 1972-09-29 1976-12-09 Ciba Geigy Ag Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico
US4338439A (en) * 1976-08-26 1982-07-06 Eli Lilly And Company 7-[2-[(Substituted benzoyl]amino]acetamido]cephalosporins
SE8009049L (sv) * 1980-03-04 1981-09-05 Eisai Co Ltd 7alfa-metoxicefalosporinderivat, sett for framstellning derav och antibakteriella lekemedel innehallande dessa foreningar
US4468394A (en) * 1981-04-02 1984-08-28 Eisai Co., Ltd. Cephalosporin compounds

Also Published As

Publication number Publication date
GB2132613B (en) 1986-05-08
AU2082783A (en) 1984-06-21
GB8329554D0 (en) 1983-12-07
ES534297A0 (es) 1985-06-01
SE8306882L (sv) 1984-06-15
IT8324122A0 (it) 1983-12-12
ATA435283A (de) 1986-12-15
PH20168A (en) 1986-10-09
ES8505691A1 (es) 1985-06-01
DE3345093A1 (de) 1984-06-14
DK572183D0 (da) 1983-12-13
DK572183A (da) 1984-06-27
ES528003A0 (es) 1985-06-16
IT1169969B (it) 1987-06-03
FR2569195B1 (fr) 1987-01-09
US4546176A (en) 1985-10-08
FR2569195A1 (fr) 1986-02-21
CH656131A5 (de) 1986-06-13
GB2132613A (en) 1984-07-11
SE8306882D0 (sv) 1983-12-13
BE898442A (fr) 1984-06-13
NL8304272A (nl) 1984-07-02
KR840007012A (ko) 1984-12-04
YU237283A (en) 1986-04-30

Similar Documents

Publication Publication Date Title
ES8505691A1 (es) Un procedimiento para preparar derivados de cefem
NZ330656A (en) Tricyclic compounds, their production and use
SE8600193L (sv) Nya cefalosporiner
ES8602673A1 (es) Un metodo para producir acidos 1,4-dihidro-4-oxo-quinolin-3-carboxilico
ES8305335A1 (es) "procedimiento de preparacion de nuevos derivados de la quinoleina".
EP0612751A3 (en) Compounds for the preparation of cephem derivatives.
ES8606361A1 (es) Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
AU6307586A (en) Quinoline derivatives
ES8202021A1 (es) Un procedimiento para la preparacion de un compuesto de ce- falosporina
HUT73172A (en) 3`-aziridino-anthracycline derivatives, pharmaceutical compns. contg. the said compds, process to prepare them and their use
IE43346L (en) Cephalosporin derivatives.
DE3170503D1 (en) 3-0-demethyl derivatives of istamycin b series compounds and their preparation
ES429864A1 (es) Procedimiento para la obtencion de derivados cefem.
ES8304973A1 (es) Un procedimiento para la preparacion de nuevos derivados de tiocarbapenem 3-sustituidos.
EP0287116A3 (en) Thiadiazolylacetamide cephem derivatives
ES8406156A1 (es) Procedimiento para la preparacion de n-pteridinil-ureas(como divisional de la patente numero 521.331)
ES454469A1 (es) Un procedimiento de produccion de derivados de 7-(4-carboxi-butiramido)-7-metoxicefalosporina.
GB1081635A (en) Novel amines and a process for the preparation thereof
AU4441593A (en) Tetrahydronaphthalene derivatives, their preparation and their application in therapy
ES2014041A6 (es) Un procedimiento para preparar un derivado de amina.
ES8201587A1 (es) Procedimiento de producir compuestos cefalosporinicos anti- microbianos
JPS56123990A (en) 7- n-acylamino-alpha-arylacetamide -3- substituted or unsubstituted-1-pyridiniummethyl cephalosporins
EP0652220A4 (en) CEPHALOSPORINE DERIVATIVES.
ES8506313A1 (es) Un procedimiento para la preparacion de nuevos derivados de 7-oxo-1-azabiciclo(3.2.0)hepteno.
GB2010835A (en) I-Thiocyanato-8-substituted naphthalene derivatives