ES8601205A1 - Procedimiento para la preparacion de nuevas 2-piperazino-pteridinas - Google Patents

Procedimiento para la preparacion de nuevas 2-piperazino-pteridinas

Info

Publication number
ES8601205A1
ES8601205A1 ES537785A ES537785A ES8601205A1 ES 8601205 A1 ES8601205 A1 ES 8601205A1 ES 537785 A ES537785 A ES 537785A ES 537785 A ES537785 A ES 537785A ES 8601205 A1 ES8601205 A1 ES 8601205A1
Authority
ES
Spain
Prior art keywords
group
pteridines
piperazino
compounds
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537785A
Other languages
English (en)
Other versions
ES537785A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KARL mbH
Original Assignee
KARL mbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KARL mbH filed Critical KARL mbH
Publication of ES8601205A1 publication Critical patent/ES8601205A1/es
Publication of ES537785A0 publication Critical patent/ES537785A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 2-PIPERAZINO-PTERIDINAS Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES DE FORMULA (I) EN LA QUE R1 R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R3-H O CON UNA DE SUS SALES DE METALES ALCALINOS FORMULAS EN LAS QUE Z3 REPRESENTA UN GRUPO INTERCAMBIABLE NUCLEOFILICAMENTE TAL COMO UN ATOMO DE HALOGENO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE A UNA TEMPERATURA ENTRE 50JC Y 150JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS DILATADORES DE LA CORONARIA SEDANTES ANTIPIRETICOS Y ANALGESICOS.
ES537785A 1983-07-02 1984-11-20 Procedimiento para la preparacion de nuevas 2-piperazino-pteridinas Granted ES537785A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833323932 DE3323932A1 (de) 1983-07-02 1983-07-02 Neue 2-piperazino-pteridine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8601205A1 true ES8601205A1 (es) 1985-10-16
ES537785A0 ES537785A0 (es) 1985-10-16

Family

ID=6203017

Family Applications (2)

Application Number Title Priority Date Filing Date
ES533298A Granted ES533298A0 (es) 1983-07-02 1984-06-11 Procedimiento para la preparacion de 2-piperazino-pferidinas
ES537785A Granted ES537785A0 (es) 1983-07-02 1984-11-20 Procedimiento para la preparacion de nuevas 2-piperazino-pteridinas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES533298A Granted ES533298A0 (es) 1983-07-02 1984-06-11 Procedimiento para la preparacion de 2-piperazino-pferidinas

Country Status (17)

Country Link
EP (1) EP0134922B1 (es)
JP (1) JPS6025991A (es)
AT (1) ATE39253T1 (es)
AU (1) AU565105B2 (es)
CA (1) CA1233179A (es)
DD (1) DD229990A5 (es)
DE (2) DE3323932A1 (es)
DK (1) DK159113C (es)
ES (2) ES533298A0 (es)
FI (1) FI80454C (es)
GB (1) GB2143232B (es)
HU (1) HU190932B (es)
IL (1) IL72265A (es)
NO (1) NO160920C (es)
NZ (1) NZ208725A (es)
PH (1) PH22493A (es)
ZA (1) ZA844968B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445298A1 (de) * 1984-12-12 1986-06-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
DE3540952C2 (de) * 1985-11-19 1997-08-14 Thomae Gmbh Dr K 2-Piperazino-pteridine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
WO2005021003A2 (en) * 2003-08-29 2005-03-10 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
DE10202468A1 (de) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung
GB2407089A (en) * 2003-10-17 2005-04-20 4 Aza Bioscience Nv Pteridine derivatives
DE102004057594A1 (de) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057645A1 (de) * 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057595A1 (de) * 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057618A1 (de) 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
EP2029600B1 (de) * 2006-05-24 2012-03-14 Boehringer Ingelheim International GmbH Substituierte pteridine, die mit einem viergliedrigen heterocyclus substituiert sind
CA2652840C (en) 2006-05-24 2014-09-09 Boehringer Ingelheim International Gmbh 2-piperazino-6-chloro-pteridines as pde4-inhibitors for the treatment of inflammatory diseases
WO2008003149A2 (en) * 2006-07-06 2008-01-10 Gilead Sciences , Inc. Substituted pteridines for the treatment and prevention of viral infections
WO2008009079A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
US9259426B2 (en) 2006-07-20 2016-02-16 Gilead Sciences, Inc. 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
WO2016141092A1 (en) 2015-03-04 2016-09-09 Gilead Sciences, Inc. Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
EP3507288B1 (en) 2016-09-02 2020-08-26 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
CN109923106B (zh) 2016-09-02 2022-09-13 吉利德科学公司 toll样受体调节剂化合物
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940972A (en) * 1957-06-27 1960-06-14 Thomae Gmbh Dr K Tri-and tetra-substituted pteridine derivatives
FR1352111A (fr) * 1962-01-25 1964-02-14 Lumiere Lab Triamino ptéridines et leur préparation

Also Published As

Publication number Publication date
GB8416682D0 (en) 1984-08-01
FI842622A7 (fi) 1985-01-03
ES8503352A1 (es) 1985-02-16
DE3323932A1 (de) 1985-01-10
HU190932B (en) 1986-12-28
ES533298A0 (es) 1985-02-16
FI80454C (fi) 1990-06-11
EP0134922A1 (de) 1985-03-27
AU3009284A (en) 1985-01-03
EP0134922B1 (de) 1988-12-14
IL72265A (en) 1987-08-31
DK316284D0 (da) 1984-06-28
DK316284A (da) 1985-01-03
GB2143232B (en) 1986-11-05
DE3475620D1 (en) 1989-01-19
DK159113C (da) 1991-02-18
PH22493A (en) 1988-09-12
FI80454B (fi) 1990-02-28
HUT34487A (en) 1985-03-28
NO160920C (no) 1989-06-14
AU565105B2 (en) 1987-09-03
NZ208725A (en) 1988-10-28
NO842631L (no) 1985-01-03
ZA844968B (en) 1986-03-26
GB2143232A (en) 1985-02-06
DK159113B (da) 1990-09-03
IL72265A0 (en) 1984-10-31
JPS6025991A (ja) 1985-02-08
ATE39253T1 (de) 1988-12-15
DD229990A5 (de) 1985-11-20
CA1233179A (en) 1988-02-23
NO160920B (no) 1989-03-06
FI842622A0 (fi) 1984-06-29
ES537785A0 (es) 1985-10-16

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