ES8601205A1 - Procedimiento para la preparacion de nuevas 2-piperazino-pteridinas - Google Patents
Procedimiento para la preparacion de nuevas 2-piperazino-pteridinasInfo
- Publication number
- ES8601205A1 ES8601205A1 ES537785A ES537785A ES8601205A1 ES 8601205 A1 ES8601205 A1 ES 8601205A1 ES 537785 A ES537785 A ES 537785A ES 537785 A ES537785 A ES 537785A ES 8601205 A1 ES8601205 A1 ES 8601205A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- pteridines
- piperazino
- compounds
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RIBWUHCWCPYSQW-UHFFFAOYSA-N 2-piperazin-1-ylpteridine Chemical class C1CNCCN1C1=NC=C(N=CC=N2)C2=N1 RIBWUHCWCPYSQW-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- -1 piperidino, morpholino, thiomorpholino Chemical group 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000002071 phenylalkoxy group Chemical group 0.000 abstract 1
- 125000004660 phenylalkylthio group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 2-PIPERAZINO-PTERIDINAS Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES DE FORMULA (I) EN LA QUE R1 R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R3-H O CON UNA DE SUS SALES DE METALES ALCALINOS FORMULAS EN LAS QUE Z3 REPRESENTA UN GRUPO INTERCAMBIABLE NUCLEOFILICAMENTE TAL COMO UN ATOMO DE HALOGENO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE A UNA TEMPERATURA ENTRE 50JC Y 150JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS DILATADORES DE LA CORONARIA SEDANTES ANTIPIRETICOS Y ANALGESICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833323932 DE3323932A1 (de) | 1983-07-02 | 1983-07-02 | Neue 2-piperazino-pteridine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8601205A1 true ES8601205A1 (es) | 1985-10-16 |
| ES537785A0 ES537785A0 (es) | 1985-10-16 |
Family
ID=6203017
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES533298A Granted ES533298A0 (es) | 1983-07-02 | 1984-06-11 | Procedimiento para la preparacion de 2-piperazino-pferidinas |
| ES537785A Granted ES537785A0 (es) | 1983-07-02 | 1984-11-20 | Procedimiento para la preparacion de nuevas 2-piperazino-pteridinas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES533298A Granted ES533298A0 (es) | 1983-07-02 | 1984-06-11 | Procedimiento para la preparacion de 2-piperazino-pferidinas |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0134922B1 (es) |
| JP (1) | JPS6025991A (es) |
| AT (1) | ATE39253T1 (es) |
| AU (1) | AU565105B2 (es) |
| CA (1) | CA1233179A (es) |
| DD (1) | DD229990A5 (es) |
| DE (2) | DE3323932A1 (es) |
| DK (1) | DK159113C (es) |
| ES (2) | ES533298A0 (es) |
| FI (1) | FI80454C (es) |
| GB (1) | GB2143232B (es) |
| HU (1) | HU190932B (es) |
| IL (1) | IL72265A (es) |
| NO (1) | NO160920C (es) |
| NZ (1) | NZ208725A (es) |
| PH (1) | PH22493A (es) |
| ZA (1) | ZA844968B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3445298A1 (de) * | 1984-12-12 | 1986-06-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel |
| DE3540952C2 (de) * | 1985-11-19 | 1997-08-14 | Thomae Gmbh Dr K | 2-Piperazino-pteridine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US7276506B2 (en) | 1998-12-28 | 2007-10-02 | 4 Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
| DE10202468A1 (de) * | 2002-01-23 | 2004-09-30 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung |
| DK1658081T3 (da) * | 2003-08-29 | 2008-02-25 | 4 Aza Ip Nv | Immunsuppressive virkninger af pteridinderivater |
| GB2407089A (en) * | 2003-10-17 | 2005-04-20 | 4 Aza Bioscience Nv | Pteridine derivatives |
| DE102004057595A1 (de) * | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057594A1 (de) | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057618A1 (de) * | 2004-11-29 | 2006-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057645A1 (de) | 2004-11-29 | 2006-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| JP5440934B2 (ja) | 2006-05-24 | 2014-03-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換プテリジン |
| ATE549338T1 (de) * | 2006-05-24 | 2012-03-15 | Boehringer Ingelheim Int | Substituierte pteridine, die mit einem viergliedrigen heterocyclus substituiert sind |
| WO2008003149A2 (en) * | 2006-07-06 | 2008-01-10 | Gilead Sciences , Inc. | Substituted pteridines for the treatment and prevention of viral infections |
| US10144736B2 (en) | 2006-07-20 | 2018-12-04 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| DK3097102T3 (en) | 2015-03-04 | 2018-01-22 | Gilead Sciences Inc | TOLL-LIKE RECEPTOR MODULATING 4,6-DIAMINO-PYRIDO [3,2-D] PYRIMIDINE COMPOUNDS |
| MA46093A (fr) | 2016-09-02 | 2021-05-19 | Gilead Sciences Inc | Composés modulateurs du recepteur de type toll |
| WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI879779B (zh) | 2019-06-28 | 2025-04-11 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2940972A (en) * | 1957-06-27 | 1960-06-14 | Thomae Gmbh Dr K | Tri-and tetra-substituted pteridine derivatives |
| FR1352111A (fr) * | 1962-01-25 | 1964-02-14 | Lumiere Lab | Triamino ptéridines et leur préparation |
-
1983
- 1983-07-02 DE DE19833323932 patent/DE3323932A1/de not_active Withdrawn
-
1984
- 1984-06-11 ES ES533298A patent/ES533298A0/es active Granted
- 1984-06-19 DE DE8484106993T patent/DE3475620D1/de not_active Expired
- 1984-06-19 EP EP84106993A patent/EP0134922B1/de not_active Expired
- 1984-06-19 AT AT84106993T patent/ATE39253T1/de not_active IP Right Cessation
- 1984-06-28 JP JP59132187A patent/JPS6025991A/ja active Pending
- 1984-06-28 DK DK316284A patent/DK159113C/da not_active IP Right Cessation
- 1984-06-29 NO NO842631A patent/NO160920C/no unknown
- 1984-06-29 CA CA000457880A patent/CA1233179A/en not_active Expired
- 1984-06-29 IL IL72265A patent/IL72265A/xx unknown
- 1984-06-29 NZ NZ208725A patent/NZ208725A/xx unknown
- 1984-06-29 FI FI842622A patent/FI80454C/fi not_active IP Right Cessation
- 1984-06-29 GB GB08416682A patent/GB2143232B/en not_active Expired
- 1984-06-29 ZA ZA844968A patent/ZA844968B/xx unknown
- 1984-06-29 PH PH30906A patent/PH22493A/en unknown
- 1984-06-29 DD DD84264739A patent/DD229990A5/de not_active IP Right Cessation
- 1984-07-02 HU HU842559A patent/HU190932B/hu not_active IP Right Cessation
- 1984-07-02 AU AU30092/84A patent/AU565105B2/en not_active Ceased
- 1984-11-20 ES ES537785A patent/ES537785A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DK316284D0 (da) | 1984-06-28 |
| DK159113C (da) | 1991-02-18 |
| GB8416682D0 (en) | 1984-08-01 |
| ZA844968B (en) | 1986-03-26 |
| FI80454B (fi) | 1990-02-28 |
| EP0134922B1 (de) | 1988-12-14 |
| IL72265A (en) | 1987-08-31 |
| ES8503352A1 (es) | 1985-02-16 |
| IL72265A0 (en) | 1984-10-31 |
| EP0134922A1 (de) | 1985-03-27 |
| GB2143232A (en) | 1985-02-06 |
| JPS6025991A (ja) | 1985-02-08 |
| ES537785A0 (es) | 1985-10-16 |
| HU190932B (en) | 1986-12-28 |
| NO160920C (no) | 1989-06-14 |
| NZ208725A (en) | 1988-10-28 |
| GB2143232B (en) | 1986-11-05 |
| NO842631L (no) | 1985-01-03 |
| FI842622A0 (fi) | 1984-06-29 |
| AU3009284A (en) | 1985-01-03 |
| FI842622A7 (fi) | 1985-01-03 |
| AU565105B2 (en) | 1987-09-03 |
| CA1233179A (en) | 1988-02-23 |
| ATE39253T1 (de) | 1988-12-15 |
| DK316284A (da) | 1985-01-03 |
| DD229990A5 (de) | 1985-11-20 |
| NO160920B (no) | 1989-03-06 |
| FI80454C (fi) | 1990-06-11 |
| DE3475620D1 (en) | 1989-01-19 |
| DK159113B (da) | 1990-09-03 |
| PH22493A (en) | 1988-09-12 |
| HUT34487A (en) | 1985-03-28 |
| ES533298A0 (es) | 1985-02-16 |
| DE3323932A1 (de) | 1985-01-10 |
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