NO842631L - Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-piperazino-pteridin-derivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-piperazino-pteridin-derivater

Info

Publication number: NO842631L
Authority: NO; Norway
Prior art keywords: piperazino; group; preparation; therapeutic active; pteridine derivatives
Prior art date: 1983-07-02

Application number

NO842631A

Other languages

English (en)

Other versions

NO160920C (no

NO160920B (no

Inventor

Josef Roch

Josef Nickl

Erich Mueller

Berthold Narr

Johannes Weisenberger

Rainer Zimmermann

Walter Haarmann

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-07-02

Filing date

1984-06-29

Publication date

1985-01-03

1984-06-29 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1985-01-03 Publication of NO842631L publication Critical patent/NO842631L/no

1989-03-06 Publication of NO160920B publication Critical patent/NO160920B/no

1989-06-14 Publication of NO160920C publication Critical patent/NO160920C/no

Links

RIBWUHCWCPYSQW-UHFFFAOYSA-N 2-piperazin-1-ylpteridine Chemical class C1CNCCN1C1=NC=C(N=CC=N2)C2=N1 RIBWUHCWCPYSQW-UHFFFAOYSA-N 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
-1 piperidino, morpholino, thiomorpholino Chemical group 0.000 abstract 4
239000002253 acid Substances 0.000 abstract 2
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
206010027476 Metastases Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000009401 metastasis Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000002071 phenylalkoxy group Chemical group 0.000 abstract 1
125000004660 phenylalkylthio group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrrole Compounds (AREA)

NO842631A 1983-07-02 1984-06-29 Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-piperazino-pteridin-derivater. NO160920C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19833323932 DE3323932A1 (de)	1983-07-02	1983-07-02	Neue 2-piperazino-pteridine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel

Publications (3)

Publication Number	Publication Date
NO842631L true NO842631L (no)	1985-01-03
NO160920B NO160920B (no)	1989-03-06
NO160920C NO160920C (no)	1989-06-14

Family

ID=6203017

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO842631A NO160920C (no)	1983-07-02	1984-06-29	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-piperazino-pteridin-derivater.

Country Status (17)

Country	Link
EP (1)	EP0134922B1 (no)
JP (1)	JPS6025991A (no)
AT (1)	ATE39253T1 (no)
AU (1)	AU565105B2 (no)
CA (1)	CA1233179A (no)
DD (1)	DD229990A5 (no)
DE (2)	DE3323932A1 (no)
DK (1)	DK159113C (no)
ES (2)	ES533298A0 (no)
FI (1)	FI80454C (no)
GB (1)	GB2143232B (no)
HU (1)	HU190932B (no)
IL (1)	IL72265A (no)
NO (1)	NO160920C (no)
NZ (1)	NZ208725A (no)
PH (1)	PH22493A (no)
ZA (1)	ZA844968B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3445298A1 (de) *	1984-12-12	1986-06-12	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
DE3540952C2 (de) *	1985-11-19	1997-08-14	Thomae Gmbh Dr K	2-Piperazino-pteridine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
WO2005021003A2 (en) *	2003-08-29	2005-03-10	4 Aza Bioscience Nv	Immunosuppressive effects of pteridine derivatives
US7276506B2 (en)	1998-12-28	2007-10-02	4 Aza Bioscience Nv	Immunosuppressive effects of pteridine derivatives
DE10202468A1 (de) *	2002-01-23	2004-09-30	Faustus Forschungs Cie. Translational Cancer Research Gmbh	Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung
GB2407089A (en) *	2003-10-17	2005-04-20	4 Aza Bioscience Nv	Pteridine derivatives
DE102004057594A1 (de)	2004-11-29	2006-06-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057645A1 (de) *	2004-11-29	2006-06-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057595A1 (de) *	2004-11-29	2006-06-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057618A1 (de)	2004-11-29	2006-06-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
EP2029600B1 (de) *	2006-05-24	2012-03-14	Boehringer Ingelheim International GmbH	Substituierte pteridine, die mit einem viergliedrigen heterocyclus substituiert sind
CA2652840C (en)	2006-05-24	2014-09-09	Boehringer Ingelheim International Gmbh	2-piperazino-6-chloro-pteridines as pde4-inhibitors for the treatment of inflammatory diseases
WO2008003149A2 (en) *	2006-07-06	2008-01-10	Gilead Sciences , Inc.	Substituted pteridines for the treatment and prevention of viral infections
WO2008009079A2 (en)	2006-07-20	2008-01-24	Gilead Sciences, Inc.	Substituted pteridines useful for the treatment and prevention of viral infections
US9259426B2 (en)	2006-07-20	2016-02-16	Gilead Sciences, Inc.	4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
WO2016141092A1 (en)	2015-03-04	2016-09-09	Gilead Sciences, Inc.	Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
EP3507288B1 (en)	2016-09-02	2020-08-26	Gilead Sciences, Inc.	4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
CN109923106B (zh)	2016-09-02	2022-09-13	吉利德科学公司	toll样受体调节剂化合物
TW202212339A (zh)	2019-04-17	2022-04-01	美商基利科學股份有限公司	類鐸受體調節劑之固體形式
TW202210480A (zh)	2019-04-17	2022-03-16	美商基利科學股份有限公司	類鐸受體調節劑之固體形式
TWI879779B (zh)	2019-06-28	2025-04-11	美商基利科學股份有限公司	類鐸受體調節劑化合物的製備方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2940972A (en) *	1957-06-27	1960-06-14	Thomae Gmbh Dr K	Tri-and tetra-substituted pteridine derivatives
FR1352111A (fr) *	1962-01-25	1964-02-14	Lumiere Lab	Triamino ptéridines et leur préparation

1983
- 1983-07-02 DE DE19833323932 patent/DE3323932A1/de not_active Withdrawn
1984
- 1984-06-11 ES ES533298A patent/ES533298A0/es active Granted
- 1984-06-19 EP EP84106993A patent/EP0134922B1/de not_active Expired
- 1984-06-19 DE DE8484106993T patent/DE3475620D1/de not_active Expired
- 1984-06-19 AT AT84106993T patent/ATE39253T1/de not_active IP Right Cessation
- 1984-06-28 DK DK316284A patent/DK159113C/da not_active IP Right Cessation
- 1984-06-28 JP JP59132187A patent/JPS6025991A/ja active Pending
- 1984-06-29 ZA ZA844968A patent/ZA844968B/xx unknown
- 1984-06-29 DD DD84264739A patent/DD229990A5/de not_active IP Right Cessation
- 1984-06-29 IL IL72265A patent/IL72265A/xx unknown
- 1984-06-29 NZ NZ208725A patent/NZ208725A/xx unknown
- 1984-06-29 PH PH30906A patent/PH22493A/en unknown
- 1984-06-29 NO NO842631A patent/NO160920C/no unknown
- 1984-06-29 FI FI842622A patent/FI80454C/fi not_active IP Right Cessation
- 1984-06-29 CA CA000457880A patent/CA1233179A/en not_active Expired
- 1984-06-29 GB GB08416682A patent/GB2143232B/en not_active Expired
- 1984-07-02 HU HU842559A patent/HU190932B/hu not_active IP Right Cessation
- 1984-07-02 AU AU30092/84A patent/AU565105B2/en not_active Ceased
- 1984-11-20 ES ES537785A patent/ES537785A0/es active Granted

Also Published As

Publication number	Publication date
GB8416682D0 (en)	1984-08-01
FI842622A7 (fi)	1985-01-03
ES8503352A1 (es)	1985-02-16
DE3323932A1 (de)	1985-01-10
HU190932B (en)	1986-12-28
ES533298A0 (es)	1985-02-16
FI80454C (fi)	1990-06-11
EP0134922A1 (de)	1985-03-27
ES8601205A1 (es)	1985-10-16
AU3009284A (en)	1985-01-03
EP0134922B1 (de)	1988-12-14
IL72265A (en)	1987-08-31
DK316284D0 (da)	1984-06-28
DK316284A (da)	1985-01-03
GB2143232B (en)	1986-11-05
DE3475620D1 (en)	1989-01-19
DK159113C (da)	1991-02-18
PH22493A (en)	1988-09-12
FI80454B (fi)	1990-02-28
HUT34487A (en)	1985-03-28
NO160920C (no)	1989-06-14
AU565105B2 (en)	1987-09-03
NZ208725A (en)	1988-10-28
ZA844968B (en)	1986-03-26
GB2143232A (en)	1985-02-06
DK159113B (da)	1990-09-03
IL72265A0 (en)	1984-10-31
JPS6025991A (ja)	1985-02-08
ATE39253T1 (de)	1988-12-15
DD229990A5 (de)	1985-11-20
CA1233179A (en)	1988-02-23
NO160920B (no)	1989-03-06
FI842622A0 (fi)	1984-06-29
ES537785A0 (es)	1985-10-16

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