ES8601695A1 - Procedimiento para la preparacion de compuestos de pteridina - Google Patents

Procedimiento para la preparacion de compuestos de pteridina

Info

Publication number
ES8601695A1
ES8601695A1 ES540684A ES540684A ES8601695A1 ES 8601695 A1 ES8601695 A1 ES 8601695A1 ES 540684 A ES540684 A ES 540684A ES 540684 A ES540684 A ES 540684A ES 8601695 A1 ES8601695 A1 ES 8601695A1
Authority
ES
Spain
Prior art keywords
formula
new
pteridine
pteridine compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540684A
Other languages
English (en)
Other versions
ES540684A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roehm Pharma GmbH
Original Assignee
Roehm Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm Pharma GmbH filed Critical Roehm Pharma GmbH
Publication of ES540684A0 publication Critical patent/ES540684A0/es
Publication of ES8601695A1 publication Critical patent/ES8601695A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE PTERIDINA. CONSISTENTES EN HACER REACCIONAR BAJO REFLUJO 2,4,6-TRIANINO-5-NITROSO PIRIDINA CON UN 10% EN EXCESO DEL BENCILCIANURO SUSTITUIDO DE FORMULA (II), PARA OBTENER EL COMPUESTO DE FORMULA (I) DONDE R1 Y R2 SON HIDROGENO, UN GRUPO ALQUILO O FORMAN PARTE DE UN HETEROCICLO DE CINCO O SEIS MIEMBROS. LA REACCION SE REALIZA BAJO CATALISIS BASICA Y A TEMPERATURA SUPERIOR A LA AMBIENTAL. COMO BASE SE EMPLEA UN ALCOHOL DE ALCALI UTILIZANDOSE EL ALCANOL CORRESPONDIENTE AL ALCOHOLATO COMO DISOLVENTE. DE ACCION DIURETICA.
ES540684A 1984-03-02 1985-02-25 Procedimiento para la preparacion de compuestos de pteridina Expired ES8601695A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843407695 DE3407695A1 (de) 1984-03-02 1984-03-02 Pteridinverbindungen mit pharmazeutischer wirksamkeit

Publications (2)

Publication Number Publication Date
ES540684A0 ES540684A0 (es) 1985-12-01
ES8601695A1 true ES8601695A1 (es) 1985-12-01

Family

ID=6229385

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540684A Expired ES8601695A1 (es) 1984-03-02 1985-02-25 Procedimiento para la preparacion de compuestos de pteridina

Country Status (14)

Country Link
US (1) US4910203A (es)
JP (1) JPS60202885A (es)
AT (1) AT392642B (es)
BE (1) BE901850A (es)
CA (1) CA1242441A (es)
CH (1) CH667269A5 (es)
DD (1) DD235871A5 (es)
DE (1) DE3407695A1 (es)
ES (1) ES8601695A1 (es)
FR (1) FR2560598B1 (es)
GB (2) GB2155923B (es)
HU (1) HU198301B (es)
IT (1) IT1183766B (es)
NL (1) NL8500564A (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3913142A1 (de) * 1989-04-21 1990-10-31 Roehm Gmbh Pharmazeutisch wirksame pteridinderivate
HU214331B (hu) * 1992-06-17 1998-03-02 Gyógyszerkutató Intézet Kft. Eljárás piperazin- és homopiperazinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
CN106967069A (zh) * 2017-03-22 2017-07-21 盐城市麦迪科化学品制造有限公司 一种氨苯蝶啶的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3081230A (en) * 1960-09-08 1963-03-12 Smith Kline French Lab Diuretic and antihypertensive triaminoarylpteridines
DE1593762A1 (de) * 1967-02-06 1972-06-08 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen substituierten 1-Phenoxy-2-hydroxy-3-alkylaminopropanen
CA945172A (en) * 1969-02-21 1974-04-09 Imperial Chemical Industries Limited Alkanolamine derivatives
GB1509527A (en) * 1974-06-05 1978-05-04 Ici Ltd 1-(aryl-or heteroaryl)oxy-3-(substituted-amino)propan-2-ol derivatives processes for their manufacture and pharmaceutical compositions containing them
DE2503222A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Verfahren zur herstellung von 1-aryl- oxy-3-n-substituierten aminopropanderivaten
DE2700073A1 (de) * 1977-01-03 1978-07-13 Roehm Pharma Gmbh Pteridinverbindungen mit pharmazeutischer wirksamkeit
FR2486082A2 (fr) * 1977-01-03 1982-01-08 Roehm Pharma Gmbh Composes de la pteridine et leur application en tant que matieres therapeutiquement actives dans des preparations pharmaceutiques
US4252809A (en) * 1977-01-03 1981-02-24 Rohm Pharma Gmbh Substituted pteridine compounds and pharmaceutical compositions containing the same
FR2387971A1 (fr) * 1977-04-19 1978-11-17 Delalande Sa Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
FR2456738A2 (fr) * 1978-04-10 1980-12-12 Delalande Sa Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique
US4285947A (en) * 1980-01-18 1981-08-25 Interx Research Corporation Aldehyde adducts of triamterene
AT370722B (de) * 1981-07-24 1983-04-25 Gerot Pharmazeutika Verfahren zur herstellung von 1-phenoxy-3-amino- 2-propanolen

Also Published As

Publication number Publication date
IT8567216A0 (it) 1985-03-01
CA1242441A (en) 1988-09-27
ATA25485A (de) 1990-10-15
AT392642B (de) 1991-05-10
US4910203A (en) 1990-03-20
GB2155923B (en) 1988-12-14
IT8567216A1 (it) 1986-09-01
FR2560598B1 (fr) 1988-03-18
NL8500564A (nl) 1985-10-01
GB2155923A (en) 1985-10-02
FR2560598A1 (fr) 1985-09-06
DD235871A5 (de) 1986-05-21
ES540684A0 (es) 1985-12-01
GB8711877D0 (en) 1987-06-24
CH667269A5 (de) 1988-09-30
DE3407695A1 (de) 1985-09-12
BE901850A (fr) 1985-06-17
GB8505277D0 (en) 1985-04-03
JPS60202885A (ja) 1985-10-14
GB2190084A (en) 1987-11-11
HUT37430A (en) 1985-12-28
HU198301B (en) 1989-09-28
IT1183766B (it) 1987-10-22

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519