ES8602019A1 - Un procedimiento para preparar compuestos de cefalosporina - Google Patents

Un procedimiento para preparar compuestos de cefalosporina

Info

Publication number
ES8602019A1
ES8602019A1 ES530071A ES530071A ES8602019A1 ES 8602019 A1 ES8602019 A1 ES 8602019A1 ES 530071 A ES530071 A ES 530071A ES 530071 A ES530071 A ES 530071A ES 8602019 A1 ES8602019 A1 ES 8602019A1
Authority
ES
Spain
Prior art keywords
compound
general formula
procedure
cephalosporin compounds
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530071A
Other languages
English (en)
Other versions
ES530071A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8602019A1 publication Critical patent/ES8602019A1/es
Publication of ES530071A0 publication Critical patent/ES530071A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE CEFALOSPORINA, DE FORMULA GENERAL (I), EN LA QUE R REPRESENTA UN GRUPO 3 O 4-CARBAMILO O UN ATOMO DE HIDROGENO; R2 REPRESENTA UN GRUPO AMINO O UN GRUPO AMINO PROTEGIDO; B ES S O S-O; Y LA LINEA DISCONTINUA INDICA QUE EL COMPUESTO ES UN COMPUESTO CEF-2-EM. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R3 REPRESENTA HIDROGENO O UN GRUPO DE BLOQUEO DE CARBOXILO; Y X ES UN RESIDUO REEMPLAZABLE DE UN NUCLEOFILO, CON UN COMPUESTO PIRIDINICO, DE FORMULA GENERAL (III), EN LA QUE R TIENE EL SIGNIFICADO YA MENCIONADO. DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR BACTERIAS PATOGENAS EN SERES HUMANOS Y ANIMALES
ES530071A 1982-06-30 1984-02-27 Un procedimiento para preparar compuestos de cefalosporina Granted ES530071A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8218874 1982-06-30

Publications (2)

Publication Number Publication Date
ES8602019A1 true ES8602019A1 (es) 1985-11-01
ES530071A0 ES530071A0 (es) 1985-11-01

Family

ID=10531380

Family Applications (2)

Application Number Title Priority Date Filing Date
ES523681A Granted ES523681A0 (es) 1982-06-30 1983-06-29 Un procedimiento para preparar compuestos de cefalosporina.
ES530071A Granted ES530071A0 (es) 1982-06-30 1984-02-27 Un procedimiento para preparar compuestos de cefalosporina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES523681A Granted ES523681A0 (es) 1982-06-30 1983-06-29 Un procedimiento para preparar compuestos de cefalosporina.

Country Status (19)

Country Link
JP (3) JPS5913787A (es)
KR (2) KR840005150A (es)
AU (1) AU1638083A (es)
BE (2) BE897162A (es)
DE (1) DE3323450A1 (es)
DK (1) DK298983A (es)
ES (2) ES523681A0 (es)
FI (1) FI832384A7 (es)
FR (2) FR2529556A1 (es)
GB (1) GB2123415A (es)
GR (1) GR77528B (es)
IT (1) IT1173727B (es)
LU (1) LU84886A1 (es)
NL (1) NL8302308A (es)
NO (1) NO832375L (es)
PL (2) PL249795A1 (es)
PT (1) PT76959B (es)
SE (1) SE8303728D0 (es)
ZA (3) ZA834759B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001833A1 (en) * 1990-07-18 1992-02-06 Peter John Mitchell Farley Process and apparatus for the production of paper products

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
JPS54157519A (en) * 1978-06-01 1979-12-12 Mitsubishi Gas Chem Co Inc Preparation of dimethylformamide
DE2940407A1 (de) * 1979-10-05 1981-04-09 Cornelius Apparate Gmbh, 4018 Langenfeld Verfahren und vorrichtung zur anreicherung von fluessigkeiten mit gasen

Also Published As

Publication number Publication date
GB8317618D0 (en) 1983-08-03
ES8500956A1 (es) 1984-11-01
FI832384L (fi) 1983-12-31
GB2123415A (en) 1984-02-01
PL249795A1 (en) 1985-06-04
SE8303728L (es) 1984-12-30
NL8302308A (nl) 1984-01-16
FI832384A7 (fi) 1983-12-31
PL242747A1 (en) 1985-01-30
DE3323450A1 (de) 1984-01-12
FI832384A0 (fi) 1983-06-29
JPS5913786A (ja) 1984-01-24
IT1173727B (it) 1987-06-24
BE897162A (fr) 1983-12-29
FR2543949A1 (fr) 1984-10-12
ZA834759B (en) 1984-08-29
JPS5913788A (ja) 1984-01-24
NO832375L (no) 1984-01-02
KR840005150A (ko) 1984-11-03
JPS5913787A (ja) 1984-01-24
BE897163A (fr) 1983-12-29
LU84886A1 (fr) 1984-03-07
PT76959A (en) 1983-07-01
ES523681A0 (es) 1984-11-01
ZA834757B (en) 1984-04-25
IT8348599A0 (it) 1983-06-29
KR840005151A (ko) 1984-11-03
GR77528B (es) 1984-09-24
FR2529556A1 (fr) 1984-01-06
ZA834758B (en) 1984-04-25
PT76959B (en) 1986-01-24
ES530071A0 (es) 1985-11-01
SE8303728D0 (sv) 1983-06-29
DK298983A (da) 1983-12-31
DK298983D0 (da) 1983-06-29
AU1638083A (en) 1984-01-05

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