ES8603184A1 - Metodo de preparar un derivado de acido b-carbolin-3-carbo- xilico - Google Patents

Metodo de preparar un derivado de acido b-carbolin-3-carbo- xilico

Info

Publication number
ES8603184A1
ES8603184A1 ES543154A ES543154A ES8603184A1 ES 8603184 A1 ES8603184 A1 ES 8603184A1 ES 543154 A ES543154 A ES 543154A ES 543154 A ES543154 A ES 543154A ES 8603184 A1 ES8603184 A1 ES 8603184A1
Authority
ES
Spain
Prior art keywords
carboline
carboxylic acid
preparing
same
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543154A
Other languages
English (en)
Other versions
ES543154A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8603184A1 publication Critical patent/ES8603184A1/es
Publication of ES543154A0 publication Critical patent/ES543154A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Toxicology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Insulating Materials (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL ACIDO B-CARBOLIN-3-CARBOXILICO, DE FORMULA GENERAL (I), EN LA QUE R4 ES METILO, ETILO O METOXIMETILO; R5 ES HIDROGENO; Y R6 ES HIDROGENO. CONSISTE EN LA CICLACION DE UN DERIVADO DE INDOL DE FORMULA GENERAL (II) EN LA QUE R4 ES METILO, ETOXI O METOXIMETILO; R5 ES HIDROXI O HIDROGENO; Y R6 ES HIDROXI O HIDROGENO, CON ACIDO GLIOXILICO O FORMALDEHIDO, PARA FORMAR EL CORRESPONDIENTE COMPUESTO DE 1,2,3,4-TETRAHIDROCARBOLINA PARA FORMAR EL CORRESPONDIENTE ESTER ETILICO DE ACIDO B-CARBOLIN-3-CARBOXILICO. Y DESPUES SE ESTERIFICA EL GRUPO HIDROXI POR REACCION CON UN COMPUESTO DE FORMULA GENERAL: RX. DE APLICACION EN FARMACIA POR SUS PROPIEDADES PSICOTROPAS.
ES543154A 1984-05-15 1985-05-14 Metodo de preparar un derivado de acido b-carbolin-3-carbo- xilico Granted ES543154A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK2401/84A DK240184D0 (da) 1984-05-15 1984-05-15 Beta-carboline-3-carboxylic acid derivatives and method of preparing the same

Publications (2)

Publication Number Publication Date
ES8603184A1 true ES8603184A1 (es) 1986-01-01
ES543154A0 ES543154A0 (es) 1986-01-01

Family

ID=8112117

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543154A Granted ES543154A0 (es) 1984-05-15 1985-05-14 Metodo de preparar un derivado de acido b-carbolin-3-carbo- xilico

Country Status (14)

Country Link
US (2) US4631285A (es)
EP (1) EP0161575B1 (es)
JP (1) JPH089615B2 (es)
AT (1) ATE53583T1 (es)
AU (1) AU581435B2 (es)
CA (1) CA1264748A (es)
DE (1) DE3578178D1 (es)
DK (1) DK240184D0 (es)
ES (1) ES543154A0 (es)
FI (1) FI83960C (es)
HU (1) HU200767B (es)
IE (1) IE58114B1 (es)
IL (1) IL75116A (es)
ZA (1) ZA853717B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
FR2562071B1 (fr) * 1984-03-30 1986-12-19 Sanofi Sa Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
DE3540653A1 (de) * 1985-11-13 1987-05-14 Schering Ag Neue 3-oxadiazol- und 3-carbonsaeure-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4952584A (en) * 1986-01-11 1990-08-28 Beecham Group P.L.C. 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
DE3609699A1 (de) * 1986-03-20 1987-09-24 Schering Ag 5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester
US4957915A (en) * 1989-02-27 1990-09-18 Biomeasure, Inc. Benzodiazepine analogs
JPH0717959B2 (ja) * 1989-03-30 1995-03-01 新日本製鐵株式会社 一方向性高磁束密度電磁鋼板の製造方法
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
EP2671507A3 (en) 2005-04-28 2014-02-19 Proteus Digital Health, Inc. Pharma-informatics system
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
CA2752373C (en) 2009-02-20 2017-10-10 To-Bbb Holding B.V. Glutathione-based drug delivery system
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1084257A (es) * 1963-11-06
JPS52123180A (en) * 1976-04-09 1977-10-17 Hitachi Ltd High dielectric strength semiconductor device
JPS5643283A (en) * 1979-08-29 1981-04-21 Schering Ag Betaacarbolinee33carboxylic acid derivative* its manufacture and psychotic medicine containing it
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
AU544731B2 (en) * 1980-02-29 1985-06-13 Schering Aktiengesellschaft Beta-carbolin -3-carboxylic acid derivatives
JPS574987A (en) * 1980-06-09 1982-01-11 Sankyo Co Ltd Pyridoindolecarboxylic acid derivative and its preparation
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3240511A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinderivaten
DK149270C (da) * 1983-05-27 1986-08-25 Schering Ag Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater
DE3335323A1 (de) * 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
IE58114B1 (en) 1993-07-14
US4748180A (en) 1988-05-31
HU200767B (en) 1990-08-28
US4631285A (en) 1986-12-23
JPH089615B2 (ja) 1996-01-31
FI83960B (fi) 1991-06-14
EP0161575A2 (en) 1985-11-21
HUT37792A (en) 1986-02-28
DE3578178D1 (de) 1990-07-19
DK240184D0 (da) 1984-05-15
JPS6140284A (ja) 1986-02-26
ATE53583T1 (de) 1990-06-15
IE851204L (en) 1985-11-15
FI851932A0 (fi) 1985-05-15
FI83960C (fi) 1991-09-25
ZA853717B (en) 1986-01-29
IL75116A0 (en) 1985-09-29
AU4241385A (en) 1985-11-21
AU581435B2 (en) 1989-02-23
EP0161575B1 (en) 1990-06-13
CA1264748A (en) 1990-01-23
ES543154A0 (es) 1986-01-01
IL75116A (en) 1989-10-31
FI851932L (fi) 1985-11-16
EP0161575A3 (en) 1987-03-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19961003