ES8606871A1 - Un procedimiento de preparacion de amoxicilina sodica - Google Patents
Un procedimiento de preparacion de amoxicilina sodicaInfo
- Publication number
- ES8606871A1 ES8606871A1 ES85548089A ES548089A ES8606871A1 ES 8606871 A1 ES8606871 A1 ES 8606871A1 ES 85548089 A ES85548089 A ES 85548089A ES 548089 A ES548089 A ES 548089A ES 8606871 A1 ES8606871 A1 ES 8606871A1
- Authority
- ES
- Spain
- Prior art keywords
- amoxycillin
- sodium
- organic solvent
- addition
- aprotic organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 title abstract 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title abstract 3
- 229960003022 amoxicillin Drugs 0.000 title abstract 3
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 title abstract 3
- 229910052708 sodium Inorganic materials 0.000 title abstract 3
- 239000011734 sodium Substances 0.000 title abstract 3
- 239000003960 organic solvent Substances 0.000 abstract 2
- ROFDDOQLDAQFRA-UHFFFAOYSA-N 2,2-diethyl-3-oxobutanedioic acid Chemical compound CCC(CC)(C(O)=O)C(=O)C(O)=O ROFDDOQLDAQFRA-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR AMOXICILINA SODICA. COMPRENDE: A) TRATAR A LA SUSPENSION DE AMOXICILINA TRIHIDRATO CON UNA BASE ORGANICA ELEGIDA ENTRE DIETILAMINA Y TRIETILAMINA, EN UNA MEZCLA DE DISOLVENTES FORMADA POR UN ALCOHOL DE BAJO PESO MOLECULAR (METANOL O N-BUTANOL) Y POR UN HIDROCARBURO HALOGENADO (CLORURO DE METILENO O 1,2-DICLOROETANO); B) AÑADIR A LA MEZCLA DE REACCION DE A) SODIO OXALACETATO DE DIETILO, CON AGITACION Y ENTRE 2 Y 15JC; Y C) TRATAR A LA SOLUCION DE B) CON METILETILCETONA O ALCOHOL ISOPROPILICO, PARA PRECIPITAR AMOXICILINA SODICA QUE SE AISLA DE LA SOLUCION POR FILTRACION. SE UTILIZA COMO ANTIBACTERIANO PARA USARLO EN MEDICINA POR VIA PARENTERAL.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES85548089A ES8606871A1 (es) | 1985-10-21 | 1985-10-21 | Un procedimiento de preparacion de amoxicilina sodica |
| CA000520923A CA1272189A (en) | 1985-10-21 | 1986-10-20 | Process for the preparation of sodium amoxycillin |
| EP86308187A EP0220925A1 (en) | 1985-10-21 | 1986-10-21 | A process for the preparation of sodium amoxycillin |
| US06/921,105 US4737585A (en) | 1985-10-21 | 1986-10-21 | Process for the preparation of sodium amoxycillin |
| AU64233/86A AU6423386A (en) | 1985-10-21 | 1986-10-21 | Process for the preparation of sodium amoxycillin |
| ZA867982A ZA867982B (en) | 1985-10-21 | 1986-10-21 | A process for the preparation of sodium amoxycillin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES85548089A ES8606871A1 (es) | 1985-10-21 | 1985-10-21 | Un procedimiento de preparacion de amoxicilina sodica |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES548089A0 ES548089A0 (es) | 1986-06-01 |
| ES8606871A1 true ES8606871A1 (es) | 1986-06-01 |
Family
ID=8489994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES85548089A Expired ES8606871A1 (es) | 1985-10-21 | 1985-10-21 | Un procedimiento de preparacion de amoxicilina sodica |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4737585A (es) |
| EP (1) | EP0220925A1 (es) |
| AU (1) | AU6423386A (es) |
| CA (1) | CA1272189A (es) |
| ES (1) | ES8606871A1 (es) |
| ZA (1) | ZA867982B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1255716B (it) * | 1992-10-05 | 1995-11-10 | Procedimento per la preparazione di antibiotici beta-lattamici sterili | |
| TW347383B (en) * | 1995-10-26 | 1998-12-11 | Biochemie Gmbh | A process for the production of a crystalline sodium salt of amoxicillin in ethanol as solvent |
| TR200003517T2 (tr) * | 1998-06-01 | 2001-06-21 | Smithkline Beecham Corporation | Amoksilin kristalin tuzlarını hazırlama prosesi |
| US6878386B1 (en) * | 1999-04-13 | 2005-04-12 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate |
| WO2011158133A1 (en) * | 2010-06-16 | 2011-12-22 | Vardhman Chemtech Limited | Improved process for preparing amoxicillin sodium |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3262928A (en) * | 1963-03-29 | 1966-07-26 | Bristol Myers Co | Process for the production of sodium alpha-aminobenzylpenicillin |
| GB1286199A (en) * | 1970-03-16 | 1972-08-23 | Beecham Group Ltd | Penicillins |
| US3669957A (en) * | 1970-04-24 | 1972-06-13 | American Home Prod | Process for the preparation of sodium ampicillin |
| GB1464026A (en) * | 1974-09-25 | 1977-02-09 | Beecham Group Ltd | Preparation of beta-lactam antibiotics |
-
1985
- 1985-10-21 ES ES85548089A patent/ES8606871A1/es not_active Expired
-
1986
- 1986-10-20 CA CA000520923A patent/CA1272189A/en not_active Expired - Fee Related
- 1986-10-21 AU AU64233/86A patent/AU6423386A/en not_active Abandoned
- 1986-10-21 US US06/921,105 patent/US4737585A/en not_active Expired - Lifetime
- 1986-10-21 EP EP86308187A patent/EP0220925A1/en not_active Withdrawn
- 1986-10-21 ZA ZA867982A patent/ZA867982B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES548089A0 (es) | 1986-06-01 |
| EP0220925A1 (en) | 1987-05-06 |
| ZA867982B (en) | 1987-07-29 |
| CA1272189A (en) | 1990-07-31 |
| US4737585A (en) | 1988-04-12 |
| AU6423386A (en) | 1987-04-30 |
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