ES8608540A1 - Procedimiento para preparar peptidos liberadores de la hormona del crecimiento. - Google Patents
Procedimiento para preparar peptidos liberadores de la hormona del crecimiento.Info
- Publication number
- ES8608540A1 ES8608540A1 ES545760A ES545760A ES8608540A1 ES 8608540 A1 ES8608540 A1 ES 8608540A1 ES 545760 A ES545760 A ES 545760A ES 545760 A ES545760 A ES 545760A ES 8608540 A1 ES8608540 A1 ES 8608540A1
- Authority
- ES
- Spain
- Prior art keywords
- growth hormone
- procedure
- acid
- hormone releasing
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 101710119601 Growth hormone-releasing peptides Proteins 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 2
- 108010051696 Growth Hormone Proteins 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001413 amino acids Chemical group 0.000 abstract 2
- 239000000122 growth hormone Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE PEPTIDOS QUE LIBERAN LA HORMONA DEL CRECIMIENTO, DE FORMULA (I), (II) O (III), Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, EN LAS QUE R1 ES HIDROGENO O ALCANOILO C1-6; A, B, C, X, Y Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. COMPRENDE LA REACCION DE ACOPLAMIENTO DE UN AMINOACIDO C-TERMINAL PROTEGIDO CON UNA RESINA CLOROMETILADA O HIDROXIMETILADA, EN PRESENCIA DE UN AGENTE DE ACOPLAMIENTO; DESPROTECCION EN PRESENCIA DE UN ACIDO; REPETICION DE LA SECUENCIA CON EL RESTO DE LOS AMINOACIDOS, POR ETAPAS, DESDE EL C-TERMINAL DEL PEPTIDO; DESUNIR EL PEPTIDO DE LA RESINA CON AMONIACO O UNA AMINA Y DESPROTEGER CON UN ACIDO. ESTOS COMPUESTOS TIENEN APLICACIONES PARA EL TRATAMIENTO DE SINTOMAS RELACIONADOS CON DEFICIENCIAS EN LA HORMONA DEL CRECIMIENTO Y PARA INCREMENTAR EL CRECIMIENTO DE LANA Y DE ANIMALES PRODUCTORES DE CARNE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52206783A | 1983-08-10 | 1983-08-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES545760A0 ES545760A0 (es) | 1986-07-16 |
| ES8608540A1 true ES8608540A1 (es) | 1986-07-16 |
Family
ID=24079327
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535032A Expired ES8606400A1 (es) | 1983-08-10 | 1984-08-09 | Procedimiento para preparar peptidos |
| ES545760A Expired ES8608540A1 (es) | 1983-08-10 | 1985-07-31 | Procedimiento para preparar peptidos liberadores de la hormona del crecimiento. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535032A Expired ES8606400A1 (es) | 1983-08-10 | 1984-08-09 | Procedimiento para preparar peptidos |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0136475B1 (es) |
| JP (1) | JPH0684400B2 (es) |
| KR (1) | KR850001772A (es) |
| AT (1) | ATE60062T1 (es) |
| AU (1) | AU575843B2 (es) |
| CA (1) | CA1268898A (es) |
| DE (1) | DE3483931D1 (es) |
| DK (1) | DK167361B1 (es) |
| ES (2) | ES8606400A1 (es) |
| FI (1) | FI86432C (es) |
| HK (1) | HK73692A (es) |
| IL (1) | IL72630A (es) |
| NO (1) | NO165804C (es) |
| NZ (1) | NZ209078A (es) |
| PT (1) | PT79055B (es) |
| SG (1) | SG28692G (es) |
| ZA (1) | ZA846191B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL70530A (en) * | 1983-01-13 | 1986-09-30 | Salk Inst For Biological Studi | Synthetic peptides having growth hormone releasing factor activity and compositions containing them |
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| PT79094B (en) * | 1983-08-29 | 1986-08-14 | Salk Inst For Biological Studi | Grf analogs |
| US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| DE3436819A1 (de) * | 1984-10-06 | 1986-04-17 | Hoechst Ag, 6230 Frankfurt | Arzneimittel mit grf-wirkung |
| CA1271600A (en) * | 1985-01-07 | 1990-07-10 | David Howard Coy | Growth hormone-releasing peptides and method of treating mammals therewith |
| EP0193910A3 (en) * | 1985-03-06 | 1988-11-23 | Sumitomo Pharmaceuticals Company, Limited | Synthesis of a derivative of grf and intermediate peptides |
| FR2594832B1 (fr) * | 1986-02-24 | 1990-05-25 | Sanofi Sa | Derives du facteur de liberation de l'hormone de croissance (grf) possedant des aminoacides modifies |
| FR2599038B1 (fr) * | 1986-05-26 | 1990-06-29 | Sanofi Sa | Procede de preparation de nonacosapeptides et peptides intermediaires |
| US5565606A (en) * | 1986-10-21 | 1996-10-15 | Hoechst Aktiengesellschaft | Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method |
| DE3742633A1 (de) * | 1987-12-16 | 1989-06-29 | Hoechst Ag | Peptide mit beeinflussender wirkung auf die hypophyse von saeugern |
| IL86102A (en) * | 1987-05-11 | 1994-04-12 | Univ Tulane | Alkylated growth hormone-releasing peptides and use thereof |
| US5002931A (en) * | 1987-05-22 | 1991-03-26 | The Salk Institute For Biological Studies | GRF analogs VII |
| USRE33699E (en) * | 1987-07-09 | 1991-09-24 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
| US4801456A (en) * | 1987-07-09 | 1989-01-31 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
| US4959352A (en) * | 1987-09-18 | 1990-09-25 | Hoffmann-La Roche Inc. | Cyclic growth hormone releasing factor analogs and method for the manufacture thereof |
| ES2054754T3 (es) * | 1987-09-18 | 1994-08-16 | Hoffmann La Roche | Analogos ciclicos del grf. |
| ATE113965T1 (de) * | 1989-06-16 | 1994-11-15 | Upjohn Co | Stabilisierte, starke grf-analoga. |
| US5756458A (en) * | 1989-06-16 | 1998-05-26 | Pharmacia & Upjohn Company | Stabilized potent GRF analogs |
| CN107936090B (zh) * | 2017-12-08 | 2021-09-24 | 陕西慧康生物科技有限责任公司 | 一种低成本合成ARK-Cu的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ204456A (en) * | 1982-06-16 | 1987-05-29 | Salk Inst For Biological Studi | Synthetic pancreatic growth-hormone releasing factor |
| US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| IL70530A (en) * | 1983-01-13 | 1986-09-30 | Salk Inst For Biological Studi | Synthetic peptides having growth hormone releasing factor activity and compositions containing them |
| DK162130C (da) * | 1983-03-07 | 1992-03-02 | Hoffmann La Roche | Grf-analoge peptider, fremgangsmaade til fremstilling deraf, grf-analoge peptider som terapeutiske midler, anvendelse af grf-analoge peptider, fremgangsmaade til fremstilling af farmaceutiske praeparater indeholdende grf-analoge peptider samt parenterale farmaceutiske praeparater indeholdende grf-analoge peptider |
-
1984
- 1984-07-31 AU AU31334/84A patent/AU575843B2/en not_active Ceased
- 1984-08-01 NZ NZ209078A patent/NZ209078A/xx unknown
- 1984-08-06 DE DE8484109312T patent/DE3483931D1/de not_active Expired - Lifetime
- 1984-08-06 AT AT84109312T patent/ATE60062T1/de not_active IP Right Cessation
- 1984-08-06 EP EP84109312A patent/EP0136475B1/en not_active Expired - Lifetime
- 1984-08-08 CA CA000460517A patent/CA1268898A/en not_active Expired - Lifetime
- 1984-08-08 KR KR1019840004730A patent/KR850001772A/ko not_active Ceased
- 1984-08-09 FI FI843141A patent/FI86432C/fi not_active IP Right Cessation
- 1984-08-09 DK DK384084A patent/DK167361B1/da not_active IP Right Cessation
- 1984-08-09 ES ES535032A patent/ES8606400A1/es not_active Expired
- 1984-08-09 ZA ZA846191A patent/ZA846191B/xx unknown
- 1984-08-09 NO NO843195A patent/NO165804C/no unknown
- 1984-08-09 IL IL72630A patent/IL72630A/xx not_active IP Right Cessation
- 1984-08-09 PT PT79055A patent/PT79055B/pt not_active IP Right Cessation
- 1984-08-10 JP JP59166634A patent/JPH0684400B2/ja not_active Expired - Lifetime
-
1985
- 1985-07-31 ES ES545760A patent/ES8608540A1/es not_active Expired
-
1992
- 1992-03-09 SG SG286/92A patent/SG28692G/en unknown
- 1992-09-24 HK HK736/92A patent/HK73692A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0136475A2 (en) | 1985-04-10 |
| DK384084A (da) | 1985-02-11 |
| DK384084D0 (da) | 1984-08-09 |
| ES545760A0 (es) | 1986-07-16 |
| EP0136475B1 (en) | 1991-01-16 |
| PT79055B (en) | 1986-08-12 |
| FI86432C (fi) | 1992-08-25 |
| FI86432B (fi) | 1992-05-15 |
| AU575843B2 (en) | 1988-08-11 |
| KR850001772A (ko) | 1985-04-01 |
| FI843141A0 (fi) | 1984-08-09 |
| ATE60062T1 (de) | 1991-02-15 |
| NZ209078A (en) | 1989-03-29 |
| IL72630A (en) | 1988-11-30 |
| ES535032A0 (es) | 1986-05-01 |
| NO165804B (no) | 1991-01-02 |
| DK167361B1 (da) | 1993-10-18 |
| PT79055A (en) | 1984-09-01 |
| CA1268898A (en) | 1990-05-08 |
| AU3133484A (en) | 1985-02-14 |
| ZA846191B (en) | 1985-03-27 |
| FI843141A7 (fi) | 1985-02-11 |
| EP0136475A3 (en) | 1987-03-11 |
| NO165804C (no) | 1991-04-10 |
| HK73692A (en) | 1992-10-02 |
| DE3483931D1 (de) | 1991-02-21 |
| ES8606400A1 (es) | 1986-05-01 |
| JPS6057000A (ja) | 1985-04-02 |
| JPH0684400B2 (ja) | 1994-10-26 |
| IL72630A0 (en) | 1984-11-30 |
| SG28692G (en) | 1992-05-15 |
| NO843195L (no) | 1985-02-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970701 |