ES8705385A1 - Procedimiento para preparar isomeros de derivados de prostaglandina - Google Patents

Procedimiento para preparar isomeros de derivados de prostaglandina

Info

Publication number
ES8705385A1
ES8705385A1 ES552554A ES552554A ES8705385A1 ES 8705385 A1 ES8705385 A1 ES 8705385A1 ES 552554 A ES552554 A ES 552554A ES 552554 A ES552554 A ES 552554A ES 8705385 A1 ES8705385 A1 ES 8705385A1
Authority
ES
Spain
Prior art keywords
procedure
formula
compound
isomers
prostaglandin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552554A
Other languages
English (en)
Other versions
ES552554A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of ES552554A0 publication Critical patent/ES552554A0/es
Publication of ES8705385A1 publication Critical patent/ES8705385A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Emergency Protection Circuit Devices (AREA)
  • Materials For Medical Uses (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PROSTAGLANDINA, DE FORMULA (I), DE SUS ISOMEROS, SALES NO TOXICAS Y CLATRATOS DE CICLODEXTRINA. COMPRENDE LA REACCION DE HIDROLISIS DE UN COMPUESTO DE FORMULA (II), (III) O (IV), PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE A, B, R1, R1B, R11, R12, R13 Y R14 PUEDEN SER VARIOS TIPOS DE RADICALES Y N VALE 0-2. TAMBIEN SE PUEDE OBTENER POR FORMACION DEL GRUPO OH MEDIANTE REDUCCION DE UN GRUPO CETO EN UN COMPUESTO ADECUADO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE HIPERTENSION, TROMBOSIS, ASMA, ULCERAS GASTRICAS Y COMO DIURETICOS.
ES552554A 1984-07-23 1986-02-28 Procedimiento para preparar isomeros de derivados de prostaglandina Expired ES8705385A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59151369A JPS6130554A (ja) 1984-07-23 1984-07-23 プロスタグランジン類似化合物のある特定の立体配置を有する異性体及びそれらを有効成分として含有する治療剤

Publications (2)

Publication Number Publication Date
ES552554A0 ES552554A0 (es) 1987-05-01
ES8705385A1 true ES8705385A1 (es) 1987-05-01

Family

ID=15517042

Family Applications (3)

Application Number Title Priority Date Filing Date
ES545457A Expired ES8609232A1 (es) 1984-07-23 1985-07-22 Procedimiento para la preparacion de un analogo a la prosta-glandina
ES552554A Expired ES8705385A1 (es) 1984-07-23 1986-02-28 Procedimiento para preparar isomeros de derivados de prostaglandina
ES552553A Expired ES8705384A1 (es) 1984-07-23 1986-02-28 Procedimiento para preparar isomeros de derivados de prostaglandina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES545457A Expired ES8609232A1 (es) 1984-07-23 1985-07-22 Procedimiento para la preparacion de un analogo a la prosta-glandina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES552553A Expired ES8705384A1 (es) 1984-07-23 1986-02-28 Procedimiento para preparar isomeros de derivados de prostaglandina

Country Status (17)

Country Link
US (2) US4935446A (es)
EP (1) EP0196380B1 (es)
JP (1) JPS6130554A (es)
KR (1) KR860001119A (es)
AT (1) ATE67484T1 (es)
AU (1) AU596947B2 (es)
CA (1) CA1264320A (es)
DE (1) DE3584158D1 (es)
DK (1) DK333385A (es)
ES (3) ES8609232A1 (es)
FI (1) FI852856L (es)
GR (1) GR851812B (es)
HU (1) HU199781B (es)
NO (1) NO852916L (es)
PT (1) PT80848B (es)
YU (3) YU45985B (es)
ZA (1) ZA855533B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2192395B (en) * 1986-07-08 1990-11-14 Kotobuki Seiyaku Co Ltd Carbacyclin derivatives
US5218139A (en) * 1990-12-27 1993-06-08 G. D. Searle & Co. Method for inhibiting IgE production
US5148032A (en) * 1991-06-28 1992-09-15 Siemens Medical Laboratories, Inc. Radiation emitting device with moveable aperture plate
US5235816A (en) * 1991-10-10 1993-08-17 Praxair Technology, Inc. Cryogenic rectification system for producing high purity oxygen
AR056968A1 (es) 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
MY145694A (en) * 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
EP1976828B1 (en) 2005-12-29 2016-12-21 Celtaxsys, Inc. Diamine derivatives as inhibitors of leukotriene a4 hydrolase
CA2666143A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
AR063280A1 (es) 2006-10-12 2009-01-21 Xenon Pharmaceuticals Inc Uso de compuestos de espiro-oxindol como agentes terapeuticos
CN105218565A (zh) * 2008-10-17 2016-01-06 泽农医药公司 螺羟吲哚化合物及其作为治疗剂的用途
WO2010045197A1 (en) * 2008-10-17 2010-04-22 Xenon Pharmaceuticals, Inc. Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
CN102753556B (zh) 2009-10-14 2015-05-13 泽农医药公司 螺-羟吲哚化合物的合成方法
NZ601667A (en) 2010-02-26 2014-10-31 Xenon Pharmaceuticals Inc Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
HK1205114A1 (en) 2012-04-12 2015-12-11 Xenon Pharmaceuticals Inc. Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
MX2015011677A (es) 2013-03-14 2016-07-08 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
TW201636017A (zh) 2015-02-05 2016-10-16 梯瓦製藥國際有限責任公司 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
US10100060B2 (en) 2016-06-16 2018-10-16 Xenon Pharmaceuticals Inc. Asymmetric synthesis of funapide
EP3551608A1 (en) 2016-12-09 2019-10-16 Celtaxsys Inc. Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase
JP7145154B2 (ja) 2016-12-09 2022-09-30 セルタクシー、エルエルシー ロイコトリエンａ４ヒドロラーゼの阻害剤
EP3551611A1 (en) 2016-12-09 2019-10-16 Celtaxsys Inc. Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087620A (en) * 1975-07-17 1978-05-02 Ono Pharmaceutical Company 15-Cycloalkyl-prostaglandin derivatives
US4180675A (en) * 1975-07-17 1979-12-25 Warner-Lambert Company 15-Cycloalkyl-prostaglandin derivatives
JPS53103464A (en) * 1977-02-21 1978-09-08 Ono Pharmaceut Co Ltd Prostaglandin x analogues and process for their preparation
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
JPS53127441A (en) * 1977-04-11 1978-11-07 Ono Pharmaceut Co Ltd Prostaglandin-like compounds and their preparation
GB1588196A (en) * 1977-06-14 1981-04-15 Ono Pharmaceutical Co Prostaglandin analogues
JPS6022710B2 (ja) * 1977-09-16 1985-06-03 小野薬品工業株式会社 プロスタグランジン類似化合物
JPS54125653A (en) * 1978-03-18 1979-09-29 Ono Pharmaceut Co Ltd Prostaglandin i2 analog, its preparation, and drug composition comprising it as active constituent
GB2017699B (en) * 1978-03-31 1983-01-12 Ono Pharmaceutical Co 6,9-methano-pgi2 analogues
JPS54130543A (en) * 1978-03-31 1979-10-09 Ono Pharmaceut Co Ltd Prostagladin i2 analog, and its preparation
US4220795A (en) * 1978-08-14 1980-09-02 Miles Laboratories, Inc. Cyclobutyl substituted derivatives of prostaglandin analogs
DE2902809A1 (de) * 1979-01-25 1980-08-07 Hoechst Ag Neue analoga von prostacyclin
DE3006865A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Hetero-imino-prostacycline
JPS58164512A (ja) * 1982-03-25 1983-09-29 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤
JPS591463A (ja) * 1982-06-28 1984-01-06 Ono Pharmaceut Co Ltd 新規なプロスタグランジンｄ類似化合物
JPS5944340A (ja) * 1982-09-08 1984-03-12 Sankyo Co Ltd メタノプロスタサイクリン誘導体の光学活性結晶性アミン塩およびその製法
JPS59163365A (ja) * 1983-03-08 1984-09-14 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物

Also Published As

Publication number Publication date
NO852916L (no) 1986-01-24
FI852856A0 (fi) 1985-07-22
ES552554A0 (es) 1987-05-01
EP0196380B1 (en) 1991-09-18
ES8609232A1 (es) 1986-09-01
EP0196380A3 (en) 1987-07-01
YU143387A (en) 1988-04-30
ES552553A0 (es) 1987-05-01
US4935446A (en) 1990-06-19
YU120185A (en) 1988-04-30
HUT39157A (en) 1986-08-28
HU199781B (en) 1990-03-28
EP0196380A2 (en) 1986-10-08
DE3584158D1 (de) 1991-10-24
KR860001119A (ko) 1986-02-22
YU46219B (sh) 1993-05-28
ES8705384A1 (es) 1987-05-01
YU45985B (sh) 1992-12-21
FI852856A7 (fi) 1986-01-24
DK333385D0 (da) 1985-07-22
PT80848B (pt) 1987-11-30
AU4523285A (en) 1986-01-30
FI852856L (fi) 1986-01-24
PT80848A (en) 1985-08-01
YU46220B (sh) 1993-05-28
AU596947B2 (en) 1990-05-24
ZA855533B (en) 1986-03-26
GR851812B (es) 1985-11-26
DK333385A (da) 1986-01-24
ATE67484T1 (de) 1991-10-15
ES545457A0 (es) 1986-09-01
YU143287A (en) 1988-04-30
JPS6130554A (ja) 1986-02-12
CA1264320A (en) 1990-01-09
US5109021A (en) 1992-04-28

Similar Documents

Publication Publication Date Title
ES8705384A1 (es) Procedimiento para preparar isomeros de derivados de prostaglandina
ES8106721A1 (es) Un metodo para la preparacion de derivados de ftalimidina
ES8704872A1 (es) Un procedimiento para preparar aril-hidroxamatos
ES8704925A1 (es) Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno
ES8704879A1 (es) Procedimiento para la obtencion de edulcorantes derivados del gem-diaminoalcano
AR019791A1 (es) Metodo para la preparacion de 5-cianoftalida.
ES8301978A1 (es) Un procedimiento para la preparacion de 2-guanidino-4-heteroaril-tiazoles.
ES8303429A1 (es) Procedimiento para la obtencion de compuestos del acido 7b-amino-tiadiazolilacetilamino-3-amoniometil-3-cefem-4-car-boxilico
AR125990A1 (es) Intermediario novedoso para la preparación de piroxasulfona
JPS5221296A (en) Producing method of concentrated phosphoric acid containing gypsum hem ihydrate which can be easily filtrated
NO20025054L (no) Oksidasjonsprosess for fremstilling av mellomproduktet 6.alfa., 9.alfa.-difluor-11.beta., 17.alfa.-dihydroksy-16.alfa.-metyl-androst-1,4-dien-3-on 17.beta.-karboksylsyre
ES2060721T3 (es) Composiciones de reactivos a base de fosfonatos y metodos para fabricar las mismas.
ES2060127T3 (es) Halogenoalquilfenil-alcoholes-cetonas y sus hidratos.
FR2608607B1 (fr) Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
ES8406424A1 (es) Procedimiento para preparar derivados de guanidina.
ES424017A1 (es) Procedimiento para la produccion de esteres del acido fos- forico.
ES8702385A1 (es) Un procedimiento para preparar un compuesto heterociclico nitrogenado
ES8300332A1 (es) Un procedimiento para la preparacion de nuevos derivados de imidazoquinazolinas
ES2053061T3 (es) Derivado de aminobutanol y procedimiento para la preparacion de 3-pirrolidinol a partir de dicho derivado.
ES8607922A1 (es) Procedimiento para preparar 9-oxo-15 a-hidroxi-16-fenoxi y 16-fenoxi sustituido-17,18,19,20-tetranorprosta-4,5,13 (e)- trienoatos
ES8604135A1 (es) Un procedimiento para la preparacion de nuevos 16-fluor-16, 17-dideshidro prostanoides
ES422967A1 (es) Procedimiento para preparar un compuesto solido a partir deacido fosforico.
ES8504792A1 (es) Un procedimiento para preparar derivados de pirimidina
ES516158A0 (es) Procedimiento de preparacion de nuevos derivados del adamantano.
AR240813A2 (es) N-fenilsulfonil-n'-pirimidinilureas, procedimiento para su preparacion, composiciones que las contienen e intermediarios para uso exclusivo en dicho procedimiento

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203