ES8705397A1 - Procedimiento para la obtencion de imidazoles sustituidos - Google Patents

Procedimiento para la obtencion de imidazoles sustituidos

Info

Publication number
ES8705397A1
ES8705397A1 ES552559A ES552559A ES8705397A1 ES 8705397 A1 ES8705397 A1 ES 8705397A1 ES 552559 A ES552559 A ES 552559A ES 552559 A ES552559 A ES 552559A ES 8705397 A1 ES8705397 A1 ES 8705397A1
Authority
ES
Spain
Prior art keywords
formula
substituted imidazoles
procedure
obtaining substituted
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552559A
Other languages
English (en)
Other versions
ES552559A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES552559A0 publication Critical patent/ES552559A0/es
Publication of ES8705397A1 publication Critical patent/ES8705397A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

METODO PARA OBTENER IMIDAZOLES SUSTITUIDOS DE FORMULA (I); R1 Y R2 SON ALQUILO INFERIOR Y PH ES FENILO INSUSTITUIDO O SUSTITUIDO POR ALQUILO, ALCOXI INFERIOR (HASTA 4C) EN POSICION 2 O 3. COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA (VIIA) CON R0-X6, EN DONDE X4, X5, X6 Y R0 SE ESCOGEN DE TAL MANERA QUE SE PRODUCE UNA REACCION EN UNA DE LAS POSICIONES OCUPADAS POR X4 O X5 (LA OTRA POSICION NO REACCIONA Y ES IGUAL A R1 O R2 SEGUN PROCEDA), CONSISTENTE EN LA INTERACCION ENTRE UN GRUPO ESTER Y UN DERIVADO ORGANICO DE LITIO PREFERENTEMENTE. LOS COMPUESTOS DE FORMULA (I) INHIBEN EN FORMA SELECTIVA Y REVERSIBLE LA MONOAMINOOXIDASA MAO DEL TIPO A Y TAMBIEN LA DEGRADACION DE LA SEROFORINA EN EL CEREBRO DE RATA SIENDO APLICABLE AL TRATAMIENTO PROFILACTICO Y TERAPEUTICO DE LOS ESTADOS DEPRESIVOS.
ES552559A 1983-12-30 1986-02-28 Procedimiento para la obtencion de imidazoles sustituidos Expired ES8705397A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH698883 1983-12-30

Publications (2)

Publication Number Publication Date
ES552559A0 ES552559A0 (es) 1987-05-01
ES8705397A1 true ES8705397A1 (es) 1987-05-01

Family

ID=4318179

Family Applications (6)

Application Number Title Priority Date Filing Date
ES539204A Expired ES8800166A1 (es) 1983-12-30 1984-12-28 Procedimiento para la obtencion de imidazoles sustituidos
ES552558A Expired ES8705396A1 (es) 1983-12-30 1986-02-28 Procedimiento para la obtencion de imidazoles sustituidos
ES552557A Expired ES8705224A1 (es) 1983-12-30 1986-02-28 Procedimiento para la obtencion de imidazoles sustituidos
ES552556A Expired ES8705395A1 (es) 1983-12-30 1986-02-28 Procedimiento para la obtencion de imidazoles sustituidos
ES552559A Expired ES8705397A1 (es) 1983-12-30 1986-02-28 Procedimiento para la obtencion de imidazoles sustituidos
ES552555A Expired ES8705394A1 (es) 1983-12-30 1986-02-28 Procedimiento para la obtencion de imidazoles sustituidos

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES539204A Expired ES8800166A1 (es) 1983-12-30 1984-12-28 Procedimiento para la obtencion de imidazoles sustituidos
ES552558A Expired ES8705396A1 (es) 1983-12-30 1986-02-28 Procedimiento para la obtencion de imidazoles sustituidos
ES552557A Expired ES8705224A1 (es) 1983-12-30 1986-02-28 Procedimiento para la obtencion de imidazoles sustituidos
ES552556A Expired ES8705395A1 (es) 1983-12-30 1986-02-28 Procedimiento para la obtencion de imidazoles sustituidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES552555A Expired ES8705394A1 (es) 1983-12-30 1986-02-28 Procedimiento para la obtencion de imidazoles sustituidos

Country Status (15)

Country Link
EP (1) EP0149976A3 (es)
JP (1) JPS60158176A (es)
AU (1) AU569135B2 (es)
CA (1) CA1233828A (es)
DD (1) DD228249A5 (es)
DK (1) DK614384A (es)
ES (6) ES8800166A1 (es)
FI (1) FI845140L (es)
GR (1) GR82625B (es)
HU (1) HU193916B (es)
IL (1) IL73955A (es)
NO (1) NO845278L (es)
NZ (1) NZ210722A (es)
PT (1) PT79761B (es)
ZA (1) ZA8410105B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3674054D1 (de) 1985-04-26 1990-10-18 Hoffmann La Roche 1,3-disubstituierte imidazoliumsalze.
JPS62103068A (ja) * 1985-09-23 1987-05-13 ヘキスト・アクチエンゲゼルシヤフト アリ−ルメチルアゾ−ルおよびそれらの塩ならびにそれらの製法
DE3628545A1 (de) * 1985-09-23 1987-04-23 Hoechst Ag Arylmethylazole und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
DE3707151A1 (de) * 1987-03-06 1988-09-15 Hoechst Ag 1-(1-aryl-2-hydroxy-ethyl)-imidazole und deren salze, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung
DE3812483A1 (de) * 1987-06-27 1989-01-05 Bayer Ag (azolyl-vinyl)-phenol-alkenylether
JPH03130266A (ja) * 1989-07-28 1991-06-04 Hodogaya Chem Co Ltd 置換フェニルアルキルイミダゾール誘導体
DE3931554A1 (de) * 1989-09-22 1991-04-04 Hoechst Ag (+)-(2-hydroxy-2-adamantyl)-1-imidazolyl-3- tolyl-methan und dessen salze, verfahren zu dessen herstellung, diese verbindung enthaltende arzneimittel und dessen verwendung
JP3938651B2 (ja) * 2000-04-13 2007-06-27 セントラル硝子株式会社 光学活性α−メチル−ビス−３、５−（トリフルオロメチル）ベンジルアミンの製造方法
DE10032335A1 (de) * 2000-07-04 2002-01-17 Cognis Deutschland Gmbh Dimethylbenzol-Derivate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1487326A (fr) * 1966-01-18 1967-07-07 Clin Byla Ets Dérivés imidazoliques et leur préparation
IE40911B1 (en) * 1974-04-11 1979-09-12 Schering Ag Imidazole derivatives and process for their manufacture
DE2546064A1 (de) * 1975-10-10 1977-04-21 Schering Ag Triazolderivate und verfahren zu ihrer herstellung
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
US4532331A (en) * 1983-04-12 1985-07-30 Smithkline Beckman Corporation 1-Benzyl-2-aminomethyl imidazole derivatives
US4581370A (en) * 1983-07-12 1986-04-08 Schering A.G. Antiarrhythmic imidazoliums

Also Published As

Publication number Publication date
PT79761A (en) 1985-01-01
ES8800166A1 (es) 1987-10-16
ES552555A0 (es) 1987-05-01
ES552556A0 (es) 1987-05-01
ES552558A0 (es) 1987-05-01
IL73955A0 (en) 1985-03-31
PT79761B (en) 1986-12-10
ZA8410105B (en) 1985-08-28
AU3723584A (en) 1985-07-04
IL73955A (en) 1988-09-30
ES8705396A1 (es) 1987-05-01
FI845140A0 (fi) 1984-12-27
ES8705395A1 (es) 1987-05-01
NO845278L (no) 1985-07-01
ES539204A0 (es) 1987-10-16
DK614384A (da) 1985-07-01
FI845140A7 (fi) 1985-07-01
EP0149976A2 (de) 1985-07-31
ES8705394A1 (es) 1987-05-01
FI845140L (fi) 1985-07-01
NZ210722A (en) 1987-06-30
ES8705224A1 (es) 1987-05-01
ES552557A0 (es) 1987-05-01
DK614384D0 (da) 1984-12-20
EP0149976A3 (de) 1986-12-10
JPS60158176A (ja) 1985-08-19
CA1233828A (en) 1988-03-08
HU193916B (en) 1987-12-28
ES552559A0 (es) 1987-05-01
HUT36463A (en) 1985-09-30
GR82625B (en) 1985-05-07
AU569135B2 (en) 1988-01-21
DD228249A5 (de) 1985-10-09

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