ES8707238A1 - Procedimiento para preparar pteridinas - Google Patents

Procedimiento para preparar pteridinas

Info

Publication number: ES8707238A1
Authority: ES; Spain
Prior art keywords: group; denotes; pteridines; piperazino; alkylphenylalkylamino
Prior art date: 1984-12-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES549806A

Other languages

English (en)

Spanish (es)

Other versions

ES549806A0 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Dr Karl Thomae GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-12

Filing date

1985-12-11

Publication date

1987-07-16

1985-12-11 Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH

1987-07-16 Publication of ES8707238A1 publication Critical patent/ES8707238A1/es

1987-07-16 Publication of ES549806A0 publication Critical patent/ES549806A0/es

Status Expired legal-status Critical Current

Links

150000003195 pteridines Chemical class 0.000 title abstract 3
239000000543 intermediate Substances 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
-1 piperazino Chemical group 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
206010027476 Metastases Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000004614 tumor growth Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

ES549806A 1984-12-12 1985-12-11 Procedimiento para preparar pteridinas Expired ES8707238A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19843445298 DE3445298A1 (de)	1984-12-12	1984-12-12	Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel

Publications (2)

Publication Number	Publication Date
ES8707238A1 true ES8707238A1 (es)	1987-07-16
ES549806A0 ES549806A0 (es)	1987-07-16

Family

ID=6252576

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES549806A Expired ES8707238A1 (es)	1984-12-12	1985-12-11	Procedimiento para preparar pteridinas

Country Status (15)

Country	Link
EP (1)	EP0185259A3 (2)
JP (1)	JPS61140585A (2)
AU (1)	AU576924B2 (2)
CA (1)	CA1252783A (2)
DE (1)	DE3445298A1 (2)
DK (1)	DK161327C (2)
ES (1)	ES8707238A1 (2)
FI (1)	FI82696C (2)
GR (1)	GR852996B (2)
IL (1)	IL77294A (2)
NO (1)	NO161373C (2)
NZ (1)	NZ214522A (2)
PH (1)	PH24451A (2)
PT (1)	PT81650B (2)
ZA (1)	ZA859462B (2)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005021003A2 (en) *	2003-08-29	2005-03-10	4 Aza Bioscience Nv	Immunosuppressive effects of pteridine derivatives
US7276506B2 (en)	1998-12-28	2007-10-02	4 Aza Bioscience Nv	Immunosuppressive effects of pteridine derivatives
WO2003001887A2 (en) *	2001-06-28	2003-01-09	Essential Therapeutics, Inc.	Fused pyrimidines as d-alanyl-d-alanine ligase inhibitors
DE10202468A1 (de) *	2002-01-23	2004-09-30	Faustus Forschungs Cie. Translational Cancer Research Gmbh	Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung
CA2537224A1 (en) *	2003-10-17	2005-05-06	4 Aza Bioscience Nv	Heterocycle-substituted pteridine derivatives and their use in therapy
GB2407089A (en) *	2003-10-17	2005-04-20	4 Aza Bioscience Nv	Pteridine derivatives
EP1720542A4 (en) *	2004-03-04	2007-11-28	Neurogen Corp	ARYL ALKYLAMINO-SUBSTITUTED CHINAZOLINE ANALOGUE
DE102004057594A1 (de) *	2004-11-29	2006-06-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057595A1 (de)	2004-11-29	2006-06-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057645A1 (de) *	2004-11-29	2006-06-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057618A1 (de)	2004-11-29	2006-06-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
RU2445315C2 (ru) *	2005-11-22	2012-03-20	Кудос Фармасьютиклз Лимитед	ПРОИЗВОДНЫЕ ПИРИДО-, ПИРАЗО- И ПИРИМИДО-ПИРИМИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ mTOR
PL1954699T3 (pl) *	2005-11-22	2013-01-31	Kudos Pharm Ltd	Pochodne pirydo-, pirazo- i pirymidopirymidyny jako inhibitory mTOR
CA2652840C (en)	2006-05-24	2014-09-09	Boehringer Ingelheim International Gmbh	2-piperazino-6-chloro-pteridines as pde4-inhibitors for the treatment of inflammatory diseases
US9259426B2 (en)	2006-07-20	2016-02-16	Gilead Sciences, Inc.	4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
WO2008009079A2 (en)	2006-07-20	2008-01-24	Gilead Sciences, Inc.	Substituted pteridines useful for the treatment and prevention of viral infections
KR101438245B1 (ko)	2006-08-23	2014-09-04	쿠도스 파마슈티칼스 리미티드	Ｍｔｏｒ 억제제로서의 2-메틸모르폴린 피리도-, 피라조- 및 피리미도-피리미딘 유도체
US8198441B2 (en)	2008-06-20	2012-06-12	Astrazeneca Ab	Process for the preparation of novel pyridopyrazines as mTOR kinase inhibitors
WO2016141092A1 (en)	2015-03-04	2016-09-09	Gilead Sciences, Inc.	Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
EP3507288B1 (en)	2016-09-02	2020-08-26	Gilead Sciences, Inc.	4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
CN109923106B (zh)	2016-09-02	2022-09-13	吉利德科学公司	toll样受体调节剂化合物
TW202212339A (zh)	2019-04-17	2022-04-01	美商基利科學股份有限公司	類鐸受體調節劑之固體形式
TW202210480A (zh)	2019-04-17	2022-03-16	美商基利科學股份有限公司	類鐸受體調節劑之固體形式
TWI879779B (zh)	2019-06-28	2025-04-11	美商基利科學股份有限公司	類鐸受體調節劑化合物的製備方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3159628A (en) *	1962-05-28	1964-12-01	Smith Kline French Lab	Pteridine-5-oxide derivatives
DE3323932A1 (de) *	1983-07-02	1985-01-10	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue 2-piperazino-pteridine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel

1984
- 1984-12-12 DE DE19843445298 patent/DE3445298A1/de not_active Withdrawn
1985
- 1985-12-05 EP EP85115459A patent/EP0185259A3/de not_active Ceased
- 1985-12-10 FI FI854862A patent/FI82696C/fi not_active IP Right Cessation
- 1985-12-11 DK DK572685A patent/DK161327C/da not_active IP Right Cessation
- 1985-12-11 PH PH33161A patent/PH24451A/en unknown
- 1985-12-11 NZ NZ214522A patent/NZ214522A/xx unknown
- 1985-12-11 JP JP60278859A patent/JPS61140585A/ja active Pending
- 1985-12-11 IL IL77294A patent/IL77294A/xx unknown
- 1985-12-11 ES ES549806A patent/ES8707238A1/es not_active Expired
- 1985-12-11 PT PT81650A patent/PT81650B/pt not_active IP Right Cessation
- 1985-12-11 NO NO854965A patent/NO161373C/no unknown
- 1985-12-11 CA CA000497336A patent/CA1252783A/en not_active Expired
- 1985-12-11 ZA ZA859462A patent/ZA859462B/xx unknown
- 1985-12-12 AU AU51232/85A patent/AU576924B2/en not_active Ceased
- 1985-12-12 GR GR852996A patent/GR852996B/el unknown

Also Published As

Publication number	Publication date
NZ214522A (en)	1988-07-28
FI854862A7 (fi)	1986-06-13
AU5123285A (en)	1986-06-19
FI82696B (fi)	1990-12-31
CA1252783A (en)	1989-04-18
NO854965L (no)	1986-06-13
DK161327B (da)	1991-06-24
DK572685A (da)	1986-06-13
ZA859462B (en)	1987-07-29
EP0185259A2 (de)	1986-06-25
PT81650A (de)	1986-01-01
NO161373C (no)	1989-08-09
NO161373B (no)	1989-05-02
DK161327C (da)	1991-12-09
AU576924B2 (en)	1988-09-08
PH24451A (en)	1990-06-25
PT81650B (pt)	1988-04-21
EP0185259A3 (de)	1989-03-01
DK572685D0 (da)	1985-12-11
ES549806A0 (es)	1987-07-16
IL77294A (en)	1989-02-28
JPS61140585A (ja)	1986-06-27
DE3445298A1 (de)	1986-06-12
FI854862A0 (fi)	1985-12-10
FI82696C (fi)	1991-04-10
GR852996B (2)	1986-04-16

Legal Events

Date	Code	Title	Description
1996-07-01	MM4A	Patent lapsed	Effective date: 19960506

Publication	Publication Date	Title
ES8707238A1 (es)	1987-07-16	Procedimiento para preparar pteridinas
ES8301977A1 (es)	1983-01-01	Un procedimiento para la preparacion del acido 9-halo-7-oxo-2,3-dihidro-7m-pirido-1,2,3-de-1,4 benzoxazin 6-carboxilico.
ZA831633B (en)	1983-12-28	New compounds,processes for their preparation and their use as medicaments
EP0163599A3 (en)	1987-02-25	Pyrimidopyrimidine derivatives, processes for producing them, pharmaceutical compositions containing them and their use as anti-allergic agents
AU565105B2 (en)	1987-09-03	Piperazino substituted pteridines
GEP19960641B (en)	1996-11-15	Process for production of [3h]-imidazo[5,1-d]-1,2,3,5-tetrazin-4-one derivatives
AU4174989A (en)	1990-04-05	Pteridines
ES8700253A1 (es)	1986-10-01	Procedimiento para preparar compuestos de 5-alquil-1-fenil- -2-piperazinoalquilpirazolin-3-ona
DK120483A (da)	1983-09-18	Phenylpiperazinderivater og fremgangsmaade til deres fremstilling
YU25684A (en)	1987-02-28	Process for making new derivatives of pyridine
EP0559116A3 (en)	1994-07-06	Microbiological process for the hydroxylation of nitrogen containing heterocyclic carbonic acids
ES8301239A1 (es)	1982-11-16	Procedimiento para la preparacion de nitratos de alquilami- nodesoxi-1.4,3.6-dianhidro-hexito sustituidos con bases pu- rinicas
ES449629A1 (es)	1977-07-01	Procedimiento para la preparacion de nuevos derivados de benzopiranona.
ES8300776A1 (es)	1982-11-01	Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina
ES8400384A1 (es)	1983-11-16	Procedimiento para la preparacion de derivados de carbaciclina.
DE3564106D1 (en)	1988-09-08	4-phenylaminopyridine derivatives, process of the preparation thereof and pharmaceutical compositions containing them
ES8406456A1 (es)	1984-08-01	Procedimiento de preparacion de derivados de piperacina
ES485333A1 (es)	1980-07-01	Procedimiento para preparar derivados 5,6,7,8-tetrahidro-4 (3h)-quinazolinonicos y sus sales
DE3362248D1 (en)	1986-04-03	Ergoline derivatives, process for producing the ergoline derivatives and pharmaceutical compositions containing them
ES478072A1 (es)	1979-07-01	Un procedimiento de preparacion de 2-metoxi-benzamidas.