ES8708185A1 - Un procedimiento para la preparacion de una emulsion de lipidos. - Google Patents

Un procedimiento para la preparacion de una emulsion de lipidos.

Info

Publication number
ES8708185A1
ES8708185A1 ES556056A ES556056A ES8708185A1 ES 8708185 A1 ES8708185 A1 ES 8708185A1 ES 556056 A ES556056 A ES 556056A ES 556056 A ES556056 A ES 556056A ES 8708185 A1 ES8708185 A1 ES 8708185A1
Authority
ES
Spain
Prior art keywords
composition
pharmaceutically acceptable
emulsifier
microemulsion compositions
phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556056A
Other languages
English (en)
Other versions
ES556056A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES556056A0 publication Critical patent/ES556056A0/es
Publication of ES8708185A1 publication Critical patent/ES8708185A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Colloid Chemistry (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

METODO DE PREPARAR UNA EMULSION DE LIPIDOS. CONSISTE EN DISPERSAR EL EMULGENTE FOSFOLIPIDO Y EL COMPONENTE DE FASE DISCONTINUA EN AGUA DESTILADA ESTERIL UTILIZANDO UNA SONDA ULTRASONICA PARA EFECTUAR UNA PRIMERA DISPERSION BRUTA, DESPUES DE LO CUAL LA MEZCLA OBTENIDA SE TRANSFIERE A UN RECIPIENTE DE ALIMENTACION DE UN MICROFLUIDIZADOR QUE SE ACCIONA A UNA PRESION DE CAMARA DE INTERACCION INTERNA DE 1.155 A 1.330 KG/CM, TRATANDOSE LA MEZCLA DURANTE 16 PASOS DISCRETOS A TRAVES DE LA UNIDAD PARA CONSEGUIR UNA MICROEMULSION UNIFORME QUE SE ESTERILIZA POR FILTRACION A TRAVES DE UN FILTRO O EN UN AUTOCLAVE A UNOS 121GC A 1,05 KG/CM DURANTE 20 MINUTOS. TIENE UTILIDAD PARA PREPARAR COMPOSICIONES FARMACEUTICAS.
ES556056A 1985-07-29 1986-06-13 Un procedimiento para la preparacion de una emulsion de lipidos. Expired ES8708185A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75979685A 1985-07-29 1985-07-29

Publications (2)

Publication Number Publication Date
ES556056A0 ES556056A0 (es) 1987-10-01
ES8708185A1 true ES8708185A1 (es) 1987-10-01

Family

ID=25056989

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556056A Expired ES8708185A1 (es) 1985-07-29 1986-06-13 Un procedimiento para la preparacion de una emulsion de lipidos.

Country Status (9)

Country Link
EP (1) EP0211258A3 (es)
JP (1) JPS6229511A (es)
KR (1) KR900003557B1 (es)
AU (1) AU589430B2 (es)
DK (1) DK354886A (es)
ES (1) ES8708185A1 (es)
GR (1) GR861462B (es)
IL (1) IL78929A0 (es)
ZA (1) ZA864031B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023271A (en) * 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions
NZ223660A (en) * 1987-03-05 1990-11-27 Liposome Co Inc Low toxicity drug-lipid complexes; methods of making them; and method of determining their toxicity
GB8714652D0 (en) * 1987-06-23 1987-07-29 Davis S S Drug emulsion
IL88076A (en) * 1987-10-28 1993-01-14 Nippon Shinyaku Co Ltd Fat emulsions as drug carriers
JP2600726B2 (ja) * 1987-11-30 1997-04-16 大正製薬株式会社 微粒子脂肪乳剤
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US5338761A (en) * 1988-09-29 1994-08-16 Shiseido Company Ltd. Emulsified composition
GB8828517D0 (en) * 1988-12-07 1989-01-11 Leopold & Co Ag Stable emulsions
EP0598116B1 (en) * 1989-11-27 1996-07-24 Nippon Shinyaku Company, Limited Fat emulsion
TW211015B (es) * 1990-01-11 1993-08-11 Nippon Shinyaku Co Ltd
DE4015108A1 (de) * 1990-05-11 1991-11-14 Leopold Pharma Gmbh Stabile emulsion zur applikation pharmakologisch aktiver wirkstoffe
IT1243193B (it) * 1990-08-10 1994-05-24 Medea Res Srl Composizioni farmaceutiche orali a base di melatonina
TW203010B (es) * 1990-10-31 1993-04-01 Otsuka Pharma Co Ltd
CA2095627C (en) * 1990-11-06 1999-01-05 Junzo Seki Stable lyophilized fatty emulsions and a process for the production thereof
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
IL101007A (en) * 1992-02-18 1997-08-14 Pharmos Ltd Dry stable compositions prepared by lyophilization
SG45449A1 (en) 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
JPH0672890A (ja) * 1992-06-26 1994-03-15 Nippon Kayaku Co Ltd オーレオバシジン類の乳化製剤
DK0589843T3 (da) 1992-09-25 2002-04-02 Novartis Ag Cyclosporinholdige farmaceutiske præparater
DE4234225A1 (de) * 1992-10-10 1994-04-14 Roehm Pharma Gmbh Stabile topische Formulierungen mit gutem Wirkstoff-Freisetzungsvermögen enthaltend mindestens ein lipophilisiertes Makrolidantibiotikum
US5969004A (en) * 1993-10-15 1999-10-19 The Gillette Company Aqueous inks
CA2182698A1 (en) * 1994-02-25 1995-08-31 Jun Sato Injectable emulsions containing antifungal triazole derivatives
ATE218359T1 (de) 1994-11-03 2002-06-15 Novartis Erfind Verwalt Gmbh Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
SE9503143D0 (sv) 1995-09-12 1995-09-12 Astra Ab New preparation
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
PT988046E (pt) 1997-01-30 2004-12-31 Novartis Ag Composicoes farmaceuticas sem oleo contendo ciclosporina a
DE69929128T2 (de) 1998-08-31 2006-06-29 Nipro Corp. Nährstoffinfusionspräparat
US6140374A (en) * 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
GB2350297A (en) * 1999-05-27 2000-11-29 Abbott Lab Injectable halogenated anesthetic formulation in emulsion form
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
HUE045482T2 (hu) 2005-06-27 2019-12-30 Glaxosmithkline Biologicals Sa Immunogén készítmény
WO2008102065A1 (fr) * 2007-02-14 2008-08-28 Commissariat A L'energie Atomique Emulsions fluorescentes pour l'imagerie optique
FR2934953B1 (fr) 2008-08-14 2011-01-21 Commissariat Energie Atomique Nanoemulsions de nanocristaux
FR2934954B1 (fr) 2008-08-14 2011-07-22 Commissariat Energie Atomique Emulsion fluorescente de vert d'indocyanine
FR2934955B1 (fr) 2008-08-14 2011-07-08 Commissariat Energie Atomique Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions
CN101461782B (zh) * 2008-12-16 2011-07-06 海南美大制药有限公司 左卡尼汀注射用亚微乳制剂
KR20130062282A (ko) * 2010-05-13 2013-06-12 아스트라제네카 아베 진정 수면제의 주사가능한 에멀젼
AU2011340797B2 (en) * 2010-12-10 2017-08-10 Ns Technologies Pty Ltd Methods for forming miniemulsions and use thereof for delivering bioactive agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS537492B2 (es) * 1973-02-12 1978-03-18
US4073943A (en) * 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
JPS6030652B2 (ja) * 1979-05-07 1985-07-17 株式会社ミドリ十字 静脈注射用脂肪乳剤
JPS5924132B2 (ja) * 1980-12-02 1984-06-07 株式会社 林原生物化学研究所 栄養補給用乳剤の製法
JPS59193814A (ja) * 1983-04-20 1984-11-02 Ajinomoto Co Inc アミノ酸含有脂肪乳剤
JPH0647533B2 (ja) * 1984-08-10 1994-06-22 裕 水島 ４−ビフエニリル酢酸系化合物含有脂肪乳剤
IL78930A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Lyophilized emulsion compositions for parenteral administration

Also Published As

Publication number Publication date
KR900003557B1 (ko) 1990-05-21
DK354886D0 (da) 1986-07-25
JPS6229511A (ja) 1987-02-07
ZA864031B (en) 1987-01-28
KR870000921A (ko) 1987-03-10
ES556056A0 (es) 1987-10-01
IL78929A0 (en) 1986-09-30
DK354886A (da) 1987-01-30
AU6021486A (en) 1987-02-05
EP0211258A3 (en) 1987-11-19
AU589430B2 (en) 1989-10-12
EP0211258A2 (en) 1987-02-25
GR861462B (en) 1986-10-02

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