ES8708249A1 - Un procedimiento para la preparacion de derivados enzimaticos - Google Patents

Un procedimiento para la preparacion de derivados enzimaticos

Info

Publication number
ES8708249A1
ES8708249A1 ES557266A ES557266A ES8708249A1 ES 8708249 A1 ES8708249 A1 ES 8708249A1 ES 557266 A ES557266 A ES 557266A ES 557266 A ES557266 A ES 557266A ES 8708249 A1 ES8708249 A1 ES 8708249A1
Authority
ES
Spain
Prior art keywords
enzyme conjugates
therapeutical use
therapeutical
conjugates
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557266A
Other languages
English (en)
Other versions
ES557266A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES557266A0 publication Critical patent/ES557266A0/es
Publication of ES8708249A1 publication Critical patent/ES8708249A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS ENZIMATICOS. CONSISTE EN HACER REACCIONAR DOS ENZIMAS, CUYOS CENTROS ACTIVOS ESTAN BLOQUEADOS POR GRUPOS CAPACES DE REACCIONAR JUNTOS PARA FORMAR UN GRUPO BLOQUEANTE REVERSIBLE DE FORMULA (I), EN MEDIO TAMPONADO ACUOSO DE PH 6,5-8,5, ENTRE 0 Y 40GC, DURANTE 30 MINUTOS A 7 DIAS, PARA OBTENER UN CONJUGADO DE PLASMINA HUMANA Y ACTIVA DESE PLASMINOGENO DE TEJIDO HUMANO. SIENDO: (I), L(-B-A-X)N; N, ENTERO DE 2 A 6; L, GRUPO NODAL DE VALENCIA N; B, GRUPO DE CONEXION HIDROFILICO LINEAL; A, GRUPO PUENTE QUE INCLUYE UN HETEROATOMO ELEGIDO ENTRE OXIGENO, AZUFRE Y NITROGENO; X, GRUPO ACILO -R-CO-; R, FUNCIONAN AROMATICA O INSATURADA NO AROMATICA. SE UTILIZA COMO ANTITROMBOTICO.
ES557266A 1984-11-30 1986-12-24 Un procedimiento para la preparacion de derivados enzimaticos Expired ES8708249A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848430253A GB8430253D0 (en) 1984-11-30 1984-11-30 Compounds

Publications (2)

Publication Number Publication Date
ES557266A0 ES557266A0 (es) 1987-10-01
ES8708249A1 true ES8708249A1 (es) 1987-10-01

Family

ID=10570498

Family Applications (3)

Application Number Title Priority Date Filing Date
ES549459A Expired ES8704542A1 (es) 1984-11-30 1985-11-29 Un procedimiento para la preparacion de derivados enzimaticos.
ES557267A Expired ES8801616A1 (es) 1984-11-30 1986-12-24 Un procedimiento para la preparacion de derivados amidinofenilicos
ES557266A Expired ES8708249A1 (es) 1984-11-30 1986-12-24 Un procedimiento para la preparacion de derivados enzimaticos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES549459A Expired ES8704542A1 (es) 1984-11-30 1985-11-29 Un procedimiento para la preparacion de derivados enzimaticos.
ES557267A Expired ES8801616A1 (es) 1984-11-30 1986-12-24 Un procedimiento para la preparacion de derivados amidinofenilicos

Country Status (9)

Country Link
EP (1) EP0184363A3 (es)
JP (1) JPS61143325A (es)
AU (1) AU5044685A (es)
DK (1) DK552485A (es)
ES (3) ES8704542A1 (es)
GB (1) GB8430253D0 (es)
GR (1) GR852876B (es)
PT (1) PT81572B (es)
ZA (1) ZA859159B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8503097A (nl) * 1985-11-11 1987-06-01 Leuven Res & Dev Vzw Geneesmiddel met thrombolytische werking.
IE64284B1 (en) * 1987-08-03 1995-07-26 Ddi Pharmaceuticals Conjugates of superoxide dismutase
DK468388A (da) * 1987-08-21 1989-02-22 Wellcome Found Kompleks af polyethylenglycol og vaevplasminogen-aktivator, fremgangsmaade til dets fremstilling og farmaceutiske kompositioner indeholdende komplekset
US5272076A (en) * 1991-06-13 1993-12-21 Eli Lilly And Company Compounds and methods for treatment of thromboembolic disorders using an adduct of t-PA
DK1379257T3 (da) * 2001-03-23 2009-12-14 Enzon Inc Anticancer-profarmakon anvendende substituerede aromatiske syrer
JPWO2019088270A1 (ja) * 2017-11-02 2020-12-03 宇部興産株式会社 蛋白分解酵素の双頭型阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028489B1 (en) * 1979-11-05 1983-10-05 Beecham Group Plc Enzyme derivatives, and their preparation
EP0091240B1 (en) * 1982-04-07 1985-12-27 Beecham Group Plc Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them
US4536391A (en) * 1982-11-17 1985-08-20 Otsuka Pharmaceutical Co. Process for preparing urokinase complex
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives

Also Published As

Publication number Publication date
JPS61143325A (ja) 1986-07-01
PT81572A (en) 1985-12-01
DK552485A (da) 1986-05-31
ES557266A0 (es) 1987-10-01
ES8801616A1 (es) 1988-02-16
GR852876B (es) 1986-03-31
EP0184363A2 (en) 1986-06-11
ZA859159B (en) 1986-11-26
EP0184363A3 (en) 1987-12-23
AU5044685A (en) 1986-06-05
GB8430253D0 (en) 1985-01-09
ES8704542A1 (es) 1987-04-01
DK552485D0 (da) 1985-11-28
ES557267A0 (es) 1988-02-16
ES549459A0 (es) 1987-04-01
PT81572B (en) 1987-07-22

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