ES8801616A1 - Un procedimiento para la preparacion de derivados amidinofenilicos - Google Patents

Un procedimiento para la preparacion de derivados amidinofenilicos

Info

Publication number
ES8801616A1
ES8801616A1 ES557267A ES557267A ES8801616A1 ES 8801616 A1 ES8801616 A1 ES 8801616A1 ES 557267 A ES557267 A ES 557267A ES 557267 A ES557267 A ES 557267A ES 8801616 A1 ES8801616 A1 ES 8801616A1
Authority
ES
Spain
Prior art keywords
enzyme conjugates
therapeutical use
therapeutical
conjugates
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557267A
Other languages
English (en)
Other versions
ES557267A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8801616A1 publication Critical patent/ES8801616A1/es
Publication of ES557267A0 publication Critical patent/ES557267A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE AMIDINOFENILICOS, DE FORMULA GENERAL (I). CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE L ES UN GRUPO NODAL DE VALENCIA N; A ES UN GRUPO QUE COMPRENDE POR LO MENOS UN HETEROATOMO SELECCIONADO ENTRE OXIGENO, AZUFRE Y NITROGENO; X ES UN GRUPO ACILO DE FORMULA, -R-CO-; Y N ES UN NUMERO ENTERO DE 2 A 6, CON UN COMPUESTO DE FORMULA GENERAL (III), EN LA QUE R5, R6, R7 Y R8 SON CADA UNO INDEPENDIENTEMENTE HIDROGENO O UN GRUPO ATRACTOR DE ELECTRONES; Y Z ES UN CONTRA-ANION, EN PRESENCIA DE UN AGENTE CONDENSANTE, EN UN DISOLVENTE DEBILMENTE BASICO Y EN PRESENCIA DE UN CATALIZADOR ACIDO. DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES TROMBOTICAS.-
ES557267A 1984-11-30 1986-12-24 Un procedimiento para la preparacion de derivados amidinofenilicos Expired ES8801616A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848430253A GB8430253D0 (en) 1984-11-30 1984-11-30 Compounds

Publications (2)

Publication Number Publication Date
ES8801616A1 true ES8801616A1 (es) 1988-02-16
ES557267A0 ES557267A0 (es) 1988-02-16

Family

ID=10570498

Family Applications (3)

Application Number Title Priority Date Filing Date
ES549459A Expired ES8704542A1 (es) 1984-11-30 1985-11-29 Un procedimiento para la preparacion de derivados enzimaticos.
ES557266A Expired ES8708249A1 (es) 1984-11-30 1986-12-24 Un procedimiento para la preparacion de derivados enzimaticos
ES557267A Expired ES8801616A1 (es) 1984-11-30 1986-12-24 Un procedimiento para la preparacion de derivados amidinofenilicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES549459A Expired ES8704542A1 (es) 1984-11-30 1985-11-29 Un procedimiento para la preparacion de derivados enzimaticos.
ES557266A Expired ES8708249A1 (es) 1984-11-30 1986-12-24 Un procedimiento para la preparacion de derivados enzimaticos

Country Status (9)

Country Link
EP (1) EP0184363A3 (es)
JP (1) JPS61143325A (es)
AU (1) AU5044685A (es)
DK (1) DK552485A (es)
ES (3) ES8704542A1 (es)
GB (1) GB8430253D0 (es)
GR (1) GR852876B (es)
PT (1) PT81572B (es)
ZA (1) ZA859159B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8503097A (nl) * 1985-11-11 1987-06-01 Leuven Res & Dev Vzw Geneesmiddel met thrombolytische werking.
IE64284B1 (en) * 1987-08-03 1995-07-26 Ddi Pharmaceuticals Conjugates of superoxide dismutase
CA1308377C (en) * 1987-08-21 1992-10-06 Henry Berger, Jr. Complex of polyethyleneglycol and tissue plasminogen activator
US5272076A (en) * 1991-06-13 1993-12-21 Eli Lilly And Company Compounds and methods for treatment of thromboembolic disorders using an adduct of t-PA
ES2331562T3 (es) * 2001-03-23 2010-01-08 Enzon, Inc. Profarmacos de agentes anticancerigenos que emplean acidos aromaticos sustituidos.
CN111542511A (zh) * 2017-11-02 2020-08-14 宇部兴产株式会社 蛋白分解酶的双头型抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3065190D1 (en) * 1979-11-05 1983-11-10 Beecham Group Plc Enzyme derivatives, and their preparation
EP0091240B1 (en) * 1982-04-07 1985-12-27 Beecham Group Plc Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them
US4536391A (en) * 1982-11-17 1985-08-20 Otsuka Pharmaceutical Co. Process for preparing urokinase complex
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives

Also Published As

Publication number Publication date
ES8708249A1 (es) 1987-10-01
DK552485D0 (da) 1985-11-28
DK552485A (da) 1986-05-31
AU5044685A (en) 1986-06-05
EP0184363A2 (en) 1986-06-11
PT81572A (en) 1985-12-01
JPS61143325A (ja) 1986-07-01
ES8704542A1 (es) 1987-04-01
EP0184363A3 (en) 1987-12-23
GR852876B (es) 1986-03-31
ES557267A0 (es) 1988-02-16
ZA859159B (en) 1986-11-26
ES557266A0 (es) 1987-10-01
GB8430253D0 (en) 1985-01-09
PT81572B (en) 1987-07-22
ES549459A0 (es) 1987-04-01

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