ES8800919A1 - Procedimiento para preparar nuevos derivados de acidos tiazolidin-4(s)-carboxilicos - Google Patents

Procedimiento para preparar nuevos derivados de acidos tiazolidin-4(s)-carboxilicos

Info

Publication number
ES8800919A1
ES8800919A1 ES556135A ES556135A ES8800919A1 ES 8800919 A1 ES8800919 A1 ES 8800919A1 ES 556135 A ES556135 A ES 556135A ES 556135 A ES556135 A ES 556135A ES 8800919 A1 ES8800919 A1 ES 8800919A1
Authority
ES
Spain
Prior art keywords
group
optionally substituted
compounds
alkyl
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556135A
Other languages
English (en)
Other versions
ES556135A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of ES8800919A1 publication Critical patent/ES8800919A1/es
Publication of ES556135A0 publication Critical patent/ES556135A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

METODO DE PREPARAR NUEVOS DERIVADOS DE ACIDOS TIAZOLIDIN-4(S)-CARBOXILICOS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON ALDEHIDOS DE FORMULAS (III), (IV), (V) Y OTRAS, EN PRESENCIA DE UN CATALIZADOR ACIDO, TAL COMO ACIDO CLORHIDRICO, Y EN UN DISOLVENTE TAL COMO AGUA Y/O METANOL O PIRIDINA, PARA OBTENER DERIVADOS DE ACIDOS TIAZOLIDIN-4(S)-CARBOXILICOS DE FORMULA (I) DONDE R1 ES UN GRUPO FURILO, TIENILO, PIRRILO, BENZOFURILO, BENZOTIENILO, BENZOPIRRILO, FENILO Y OTROS; R2 ES H O UN EQUIVALENTE DE METAL ALCALINO O ALCALINOTERREO; Y R3 ES H, UN GRUPO ALQUILO O ACILO CON 4 ATOMOS DE CARBONO. TIENEN APLICACIONES FARMACEUTICAS POR SU EFECTO HEPATO-PROTECTOR.
ES556135A 1985-06-18 1986-06-17 Procedimiento para preparar nuevos derivados de acidos tiazolidin-4(s)-carboxilicos Expired ES8800919A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU852388A HU200177B (en) 1985-06-18 1985-06-18 Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds

Publications (2)

Publication Number Publication Date
ES8800919A1 true ES8800919A1 (es) 1987-12-01
ES556135A0 ES556135A0 (es) 1987-12-01

Family

ID=10959103

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556135A Expired ES8800919A1 (es) 1985-06-18 1986-06-17 Procedimiento para preparar nuevos derivados de acidos tiazolidin-4(s)-carboxilicos

Country Status (21)

Country Link
US (1) US4775675A (es)
EP (1) EP0206197A1 (es)
JP (1) JPS6248672A (es)
KR (1) KR870000312A (es)
CN (1) CN86104085A (es)
AR (1) AR241532A1 (es)
BG (1) BG46457A3 (es)
DD (1) DD259866A5 (es)
DK (1) DK259386A (es)
ES (1) ES8800919A1 (es)
FI (1) FI862608A7 (es)
GB (1) GB2177089B (es)
GR (1) GR861517B (es)
HU (1) HU200177B (es)
IL (1) IL78942A0 (es)
IN (1) IN165646B (es)
NO (1) NO862408L (es)
PH (1) PH22790A (es)
PL (2) PL148541B1 (es)
PT (1) PT82769B (es)
SU (2) SU1443800A3 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5740492A (en) * 1980-08-22 1982-03-06 Yamanouchi Pharmaceut Co Ltd Novel 2-phenylimidazo 2,1-b benzothiazole derivative
CN1030415A (zh) * 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
IT1223565B (it) * 1987-12-21 1990-09-19 Zambon Spa Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica
JP2726999B2 (ja) * 1988-06-22 1998-03-11 日研化学株式会社 イミダゾ［２，１−ｂ］ベンゾチアゾール誘導体及び該化合物を有効成分とする抗潰瘍剤
GB9026114D0 (en) * 1990-11-30 1991-01-16 Norsk Hydro As New compounds
DE69214467T3 (de) * 1991-01-10 2000-09-28 Transcend Therapeutics, Inc. Verwendung von L-2-oxo Thiazolidin-4-carboxylat zur Behandlung von Atemnotsyndrom
US5747459A (en) * 1991-02-04 1998-05-05 Nestec, Ltd. Method for insuring adequate intracellular glutathione in tissue
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US5214062A (en) * 1992-04-08 1993-05-25 Clintec Nutrition Co. Method and composition for treating immune disorders, inflammation and chronic infections
US5430045A (en) * 1992-04-23 1995-07-04 Free Radical Sciences, Inc. Method of reducing or preventing bone marrow hypoplasia
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
US6083966A (en) * 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
NZ509172A (en) * 1998-09-21 2004-02-27 Univ Florida Antimalarial agents
WO2000073269A2 (en) * 1999-06-02 2000-12-07 Regents Of The University Of Minnesota Nicotine receptor ligands
US6413999B1 (en) 1999-08-17 2002-07-02 University Of Saskatchewan Technologies Inc. Treatment for acute physical insult to the central nervous system
AU2003270473A1 (en) * 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
DE102004021658A1 (de) * 2004-05-03 2005-12-01 Rudy Dr. Susilo Kombinationspräparate enthaltend 2-Methylthiazolidin-2,4-dicarbonsäure
ES2732625T3 (es) 2005-04-04 2019-11-25 Univ Florida Análogos de poliéter de desferritiocina
CN104003955A (zh) * 2007-03-15 2014-08-27 佛罗里达大学研究基金公司 去铁硫辛聚醚类似物
BR112014014544A2 (pt) 2011-12-16 2017-06-13 Univ Florida usos de análogos de 4'-desferritiocina
KR20160003652A (ko) 2013-03-15 2016-01-11 캔써 리써치 테크놀로지, 엘엘씨 감마―글루타밀 주기 조절 방법 및 조성물
US10010535B2 (en) 2013-11-22 2018-07-03 University Of Florida Research Foundation, Incorporated Desferrithiocin analogs and uses thereof
WO2016176343A1 (en) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR923562A (fr) * 1946-02-01 1947-07-10 Tube électronique
CH540234A (de) * 1968-09-06 1973-08-15 Degussa Verfahren zur Herstellung von Penicillamin
ES381037A1 (es) * 1969-06-05 1973-07-01 Ferlux Acido tiazolidin dicarboxilico-2,4 y sus derivados y proce-dimiento para su obtencion.
DE2116629A1 (en) * 1971-04-05 1972-10-19 Institutul de Biochimie, Bukarest 4-thiazolidinecarboxylic acid derivs - with in vivo thiol liberating activity
CA962269A (en) * 1971-05-05 1975-02-04 Uniroyal Ltd. Thiazoles, and their use as insecticides
US3947464A (en) * 1972-07-28 1976-03-30 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler Salts of phenylpropanolamine with thiazolidine carboxylic acids
DE2446100C3 (de) * 1974-09-26 1982-01-14 Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren Phenoxyalkancarbonsäureamide von Thiazolidincarbonsäuren, Verfahren zu ihrer Herstellung und Arzneimittel
GB1473752A (en) * 1975-04-09 1977-05-18 Rexolin Chem Ab Composition of nitrofurans and its use in controlling formation of slime
FR2356423A1 (fr) * 1976-07-01 1978-01-27 Oeriu Simion Derives de l'acide thiazolidinecarboxylique, leur preparation et leur application comme medicaments
EP0045281B1 (de) * 1980-07-28 1985-05-08 Ciba-Geigy Ag Thiazolinderivate und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
SU1443800A3 (ru) 1988-12-07
PH22790A (en) 1988-12-12
PT82769A (en) 1986-07-01
IL78942A0 (en) 1986-09-30
GB2177089B (en) 1989-07-19
GB2177089A (en) 1987-01-14
FI862608A0 (fi) 1986-06-18
DK259386D0 (da) 1986-06-02
BG46457A3 (bg) 1989-12-15
JPS6248672A (ja) 1987-03-03
AR241532A1 (es) 1992-08-31
GB8614616D0 (en) 1986-07-23
PL148541B1 (en) 1989-10-31
CN86104085A (zh) 1987-04-22
HUT41774A (en) 1987-05-28
FI862608A7 (fi) 1986-12-19
SU1475905A1 (ru) 1989-04-30
ES556135A0 (es) 1987-12-01
KR870000312A (ko) 1987-02-17
EP0206197A1 (de) 1986-12-30
DK259386A (da) 1986-12-19
PT82769B (pt) 1988-04-21
PL149453B1 (en) 1990-02-28
HU200177B (en) 1990-04-28
DD259866A5 (de) 1988-09-07
NO862408D0 (no) 1986-06-17
NO862408L (no) 1986-12-19
US4775675A (en) 1988-10-04
IN165646B (es) 1989-12-02
GR861517B (en) 1986-10-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603