ES8801792A1 - Un procedimiento para la obtencion de 5-aril-1.4-dihidroporidinas - Google Patents

Un procedimiento para la obtencion de 5-aril-1.4-dihidroporidinas

Info

Publication number
ES8801792A1
ES8801792A1 ES557406A ES557406A ES8801792A1 ES 8801792 A1 ES8801792 A1 ES 8801792A1 ES 557406 A ES557406 A ES 557406A ES 557406 A ES557406 A ES 557406A ES 8801792 A1 ES8801792 A1 ES 8801792A1
Authority
ES
Spain
Prior art keywords
aryl
optionally substituted
alkyl
nitro
alkoxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557406A
Other languages
English (en)
Other versions
ES557406A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8801792A1 publication Critical patent/ES8801792A1/es
Publication of ES557406A0 publication Critical patent/ES557406A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 5-ARIL-1,4-DIHIDROPIRIDINAS, DE FORMULA (I). COMPRENDE LA REACCION DE UN ALDEHIDO DE FORMULA RCHO CON UN CETOCOMPUESTO DE FORMULA (II) Y UNA ENAMINA DE FORMULA (III), EN PRESENCIA DE AGUA O DE UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y 200JC, PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE X, Y, R, R1. R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD SOBRE LA CIRCULACION.
ES557406A 1985-01-22 1987-02-16 Un procedimiento para la obtencion de 5-aril-1.4-dihidroporidinas Expired ES8801792A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853501855 DE3501855A1 (de) 1985-01-22 1985-01-22 5-aryl-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Publications (2)

Publication Number Publication Date
ES8801792A1 true ES8801792A1 (es) 1988-02-16
ES557406A0 ES557406A0 (es) 1988-02-16

Family

ID=6260346

Family Applications (5)

Application Number Title Priority Date Filing Date
ES551082A Expired ES8705861A1 (es) 1985-01-22 1986-01-21 Un procedimiento para la obtencion de 5-aril 1-4, dihidropiridinas.
ES557407A Expired ES8801793A1 (es) 1985-01-22 1987-02-16 Un procedimiento para la obtencion de 5-aril-1.4-dihidroporidinas
ES557406A Expired ES8801792A1 (es) 1985-01-22 1987-02-16 Un procedimiento para la obtencion de 5-aril-1.4-dihidroporidinas
ES557409A Expired ES8801795A1 (es) 1985-01-22 1987-02-16 Un procedimiento para la obtencion de 5-aril-1.4-dihidroporidinas
ES557408A Expired ES8801794A1 (es) 1985-01-22 1987-02-16 Un procedimiento para la obtencion de 5-aril-1.4-dihidroporidinas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES551082A Expired ES8705861A1 (es) 1985-01-22 1986-01-21 Un procedimiento para la obtencion de 5-aril 1-4, dihidropiridinas.
ES557407A Expired ES8801793A1 (es) 1985-01-22 1987-02-16 Un procedimiento para la obtencion de 5-aril-1.4-dihidroporidinas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557409A Expired ES8801795A1 (es) 1985-01-22 1987-02-16 Un procedimiento para la obtencion de 5-aril-1.4-dihidroporidinas
ES557408A Expired ES8801794A1 (es) 1985-01-22 1987-02-16 Un procedimiento para la obtencion de 5-aril-1.4-dihidroporidinas

Country Status (13)

Country Link
US (1) US4791122A (es)
EP (1) EP0189057B1 (es)
JP (1) JPH0678309B2 (es)
AT (1) ATE50447T1 (es)
AU (1) AU577436B2 (es)
CA (1) CA1296731C (es)
DE (2) DE3501855A1 (es)
DK (1) DK30086A (es)
ES (5) ES8705861A1 (es)
GR (1) GR860143B (es)
NO (1) NO860046L (es)
PT (1) PT81878B (es)
ZA (1) ZA86435B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1002248B (en) * 1988-03-08 1996-04-23 Egyt Gyogyszervegyeszeti Gyar 1,4-dihydropyridine derivatives preparation method
JPH032161A (ja) * 1989-05-31 1991-01-08 Fujirebio Inc １，４―ジヒドロピリジン誘導体
US5276150A (en) * 1989-05-31 1994-01-04 Fujirebio Inc. 1,4-dihydropyridine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2741260A1 (de) * 1977-09-14 1979-03-22 Bayer Ag Neue 1,4-dihydropyridazine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines

Also Published As

Publication number Publication date
EP0189057A3 (en) 1986-10-08
JPS61167657A (ja) 1986-07-29
DK30086A (da) 1986-07-23
ATE50447T1 (de) 1990-03-15
AU5223886A (en) 1986-07-31
ES8801793A1 (es) 1988-02-16
EP0189057B1 (de) 1990-02-21
ES8801795A1 (es) 1988-02-16
DE3501855A1 (de) 1986-07-24
NO860046L (no) 1986-07-23
ES557406A0 (es) 1988-02-16
DE3669072D1 (de) 1990-03-29
ES551082A0 (es) 1987-05-16
PT81878B (pt) 1988-05-27
DK30086D0 (da) 1986-01-21
AU577436B2 (en) 1988-09-22
ES557409A0 (es) 1988-02-16
JPH0678309B2 (ja) 1994-10-05
ES8705861A1 (es) 1987-05-16
CA1296731C (en) 1992-03-03
US4791122A (en) 1988-12-13
GR860143B (en) 1986-05-16
EP0189057A2 (de) 1986-07-30
ES557408A0 (es) 1988-02-16
ZA86435B (en) 1986-09-24
ES557407A0 (es) 1988-02-16
PT81878A (en) 1986-02-01
ES8801794A1 (es) 1988-02-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203