ES8802113A1 - Metodo de fabricacion de un nuevo sistema distribuidor para la descarga a velocidad controlada de farmacos beneficiosos - Google Patents
Metodo de fabricacion de un nuevo sistema distribuidor para la descarga a velocidad controlada de farmacos beneficiososInfo
- Publication number
- ES8802113A1 ES8802113A1 ES556375A ES556375A ES8802113A1 ES 8802113 A1 ES8802113 A1 ES 8802113A1 ES 556375 A ES556375 A ES 556375A ES 556375 A ES556375 A ES 556375A ES 8802113 A1 ES8802113 A1 ES 8802113A1
- Authority
- ES
- Spain
- Prior art keywords
- beneficial agent
- rate controlled
- dispenser
- controlled dispenser
- administering beneficial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000009286 beneficial effect Effects 0.000 title abstract 4
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- External Artificial Organs (AREA)
Abstract
METODO DE FABRICACION DE UN SISTEMA DISTRIBUIDOR PARA LA DESCARGA A VELOCIDAD CONTROLADA DE FARMACOS BENEFICIOSOS EN EL QUE UN PORTADOR TERMOSENSIBLE FUNDIDO SE MEZCLA CON EL FARMACO, CONSTITUYENDO UNA COMPOSICION TERMOSENSIBLE, PORTADORA DEL FARMACO QUE CALENTADO SE VIERTE EN UN MOLDE Y SE DEJA ENFRIAR HASTA TEMPERATURA AMBIENTE. EN EL MOLDE SE INTRODUCE UN OSMOAGENTE SOLIDO HASTA FORMAR UN ESTRATIFICADO CON LA COMPOSICION TERMOSENSIBLE. EL ESTRATIFICADO SE RECUBRE CON UNA SOLUCION DEL CONSTITUYENTE DE LA PARED Y SE SECA EN UNA CORRIENTE DE AIRE SECO A TEMPERATURA AMBIENTE. SI ES NECESARIO, SE TALADRA A TRAVES DE LA PARED EXTERNA UNO O VARIOS CONDUCTOS DE SALIDA PARA CONECTAR EL EXTERIOR DEL DISTRIBUIDOR CON LA COMPOSICION DEL FARMACO TERMOSENSIBLE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/763,493 US4684524A (en) | 1984-03-19 | 1985-08-08 | Rate controlled dispenser for administering beneficial agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8802113A1 true ES8802113A1 (es) | 1988-04-01 |
| ES556375A0 ES556375A0 (es) | 1988-04-01 |
Family
ID=25067977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES556375A Expired ES8802113A1 (es) | 1985-08-08 | 1986-06-20 | Metodo de fabricacion de un nuevo sistema distribuidor para la descarga a velocidad controlada de farmacos beneficiosos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4684524A (es) |
| JP (1) | JPH0759497B2 (es) |
| AU (3) | AU590308B2 (es) |
| BE (1) | BE905255A (es) |
| BR (1) | BR8603756A (es) |
| CA (1) | CA1265966A (es) |
| DE (1) | DE3626103C2 (es) |
| ES (1) | ES8802113A1 (es) |
| FR (1) | FR2585951B1 (es) |
| GB (1) | GB2178660B (es) |
| IT (1) | IT1195819B (es) |
| NL (1) | NL8601981A (es) |
| NZ (1) | NZ217024A (es) |
| ZA (1) | ZA865982B (es) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5948769A (en) * | 1984-01-28 | 1999-09-07 | Ismail; Roshdy | Agent for treating heart diseases |
| DE3582439D1 (de) * | 1984-01-28 | 1991-05-16 | Roshdy Ismail | Mittel zur behandlung von herzerkrankungen. |
| US4844984A (en) * | 1984-03-19 | 1989-07-04 | Alza Corporation | Dispensing system with means for increasing delivery of beneficial agent from the system |
| US5000957A (en) * | 1984-03-19 | 1991-03-19 | Alza Corporation | Dispenser comprising hydrophilic osmopolymer |
| US4814180A (en) * | 1984-03-21 | 1989-03-21 | Alza Corporation | Agent dispenser comprising a semipermeable wall surrounding single-piece or two-piece container |
| US4716496A (en) * | 1986-05-09 | 1987-12-29 | Eaton Corporation | Panel-mounted control station housing |
| US4904477A (en) * | 1987-07-08 | 1990-02-27 | American Home Products Corporation | Spray dried ibuprofen compositions |
| GB8717168D0 (en) * | 1987-07-21 | 1987-08-26 | Roussel Lab Ltd | Controlled-release device |
| US4898734A (en) * | 1988-02-29 | 1990-02-06 | Massachusetts Institute Of Technology | Polymer composite for controlled release or membrane formation |
| US4966769A (en) * | 1988-06-02 | 1990-10-30 | Alza Corporation | Method for delivering dosage form for diltiazem |
| JP2835051B2 (ja) * | 1988-07-06 | 1998-12-14 | オリンパス光学工業株式会社 | 医療用カプセル |
| US5612059A (en) * | 1988-08-30 | 1997-03-18 | Pfizer Inc. | Use of asymmetric membranes in delivery devices |
| IL91398A (en) * | 1988-08-30 | 1994-05-30 | Pfizer | Pharmaceutical delivery device comprising active substance surrounded by asymmetric membrane |
| US5108756A (en) * | 1989-01-12 | 1992-04-28 | Pfizer Inc. | Dispensing devices powered by lyotropic liquid crystals |
| IL92966A (en) * | 1989-01-12 | 1995-07-31 | Pfizer | Dispensing devices powered by hydrogel |
| US5030452A (en) * | 1989-01-12 | 1991-07-09 | Pfizer Inc. | Dispensing devices powered by lyotropic liquid crystals |
| GB8903564D0 (en) * | 1989-02-16 | 1989-04-05 | Rashid Abdul | Drug dispensing device |
| US5342624A (en) * | 1989-02-16 | 1994-08-30 | British Technology Group Ltd. | Dispensing device |
| US5372776A (en) * | 1989-04-07 | 1994-12-13 | Alza Corporation | Density element and method of manufacture thereof to achieve a particular transverse rupture strength |
| US5206024A (en) * | 1989-04-07 | 1993-04-27 | Alza Corporation | Density element for ruminal delivery device |
| US5417976A (en) * | 1989-04-07 | 1995-05-23 | Alza | Density element and method of manufacture thereof |
| US5100392A (en) * | 1989-12-08 | 1992-03-31 | Biosynthesis, Inc. | Implantable device for administration of drugs or other liquid solutions |
| US5474785A (en) * | 1990-01-24 | 1995-12-12 | Alza Corporation | Delivery system comprising means for controlling internal pressure |
| US5223266A (en) * | 1990-01-24 | 1993-06-29 | Alza Corporation | Long-term delivery device with early startup |
| US5156623A (en) * | 1990-04-16 | 1992-10-20 | Olympus Optical Co., Ltd. | Sustained release material and method of manufacturing the same |
| ATE118345T1 (de) * | 1990-08-07 | 1995-03-15 | Pfizer | Verwendung von interfacial polymerisierten membranen in abgabevorrichtungen. |
| FI923023A7 (fi) * | 1990-10-31 | 1992-06-29 | Baxter Int | Lähellään tapahtuvan verisuonittumisen aikaansaava istutemateriaali |
| US5713888A (en) * | 1990-10-31 | 1998-02-03 | Baxter International, Inc. | Tissue implant systems |
| US5545223A (en) * | 1990-10-31 | 1996-08-13 | Baxter International, Inc. | Ported tissue implant systems and methods of using same |
| US5314696A (en) * | 1991-06-27 | 1994-05-24 | Paulos Manley A | Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor |
| US5302397A (en) * | 1991-11-19 | 1994-04-12 | Amsden Brian G | Polymer-based drug delivery system |
| US5795882A (en) * | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
| JP3722832B2 (ja) * | 1992-06-22 | 2005-11-30 | ルーナー、コーポレーション | 経口用1α−ヒドロキシプレビタミンD |
| US5609885A (en) * | 1992-09-15 | 1997-03-11 | Alza Corporation | Osmotic membrane and delivery device |
| US6191105B1 (en) | 1993-05-10 | 2001-02-20 | Protein Delivery, Inc. | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
| US5681811A (en) * | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| AU697044B2 (en) * | 1993-06-14 | 1998-09-24 | Emisphere Technologies, Inc. | Proteinoid carriers |
| US5651976A (en) * | 1993-06-17 | 1997-07-29 | The United States Of America As Represented By The Secretary Of The Navy | Controlled release of active agents using inorganic tubules |
| JPH08503715A (ja) * | 1993-09-24 | 1996-04-23 | バクスター、インターナショナル、インコーポレイテッド | 埋め込み装置の血管化を促進するための方法 |
| US6156305A (en) * | 1994-07-08 | 2000-12-05 | Baxter International Inc. | Implanted tumor cells for the prevention and treatment of cancer |
| US5607696A (en) * | 1995-02-10 | 1997-03-04 | Alza Corporation | Osmotic membrane and delivery device |
| US6395292B2 (en) * | 1996-02-02 | 2002-05-28 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
| US6703381B1 (en) | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
| US6309633B1 (en) | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
| US7169889B1 (en) | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
| US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
| US6867183B2 (en) | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
| US6828305B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| US6713452B2 (en) * | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US7196059B2 (en) | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| US6913903B2 (en) | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| AU2003236521A1 (en) * | 2002-06-13 | 2003-12-31 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
| EP1596767B1 (en) | 2003-02-12 | 2018-10-03 | Syncera, Inc. | Random and non-random alkylene oxide polymer alloy compositions |
| RU2527893C2 (ru) | 2004-07-19 | 2014-09-10 | Биокон Лимитед | Инсулин-олигомерные конъюгаты, их препараты и применения |
| CA2624897C (en) * | 2005-10-12 | 2017-02-14 | Proventiv Therapeutics, Llc | Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency |
| ES2593047T3 (es) | 2006-02-03 | 2016-12-05 | Opko Renal, Llc | Tratamiento de la insuficiencia y deficiencia de vitamina D con 25-hidroxivitamina D2 y 25-hidroxivitamina D3 |
| ES2670029T3 (es) | 2006-06-21 | 2018-05-29 | Opko Ireland Global Holdings, Ltd. | Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D |
| US11752158B2 (en) * | 2007-04-25 | 2023-09-12 | Eirgen Pharma Ltd. | Method of treating vitamin D insufficiency and deficiency |
| US8592401B2 (en) * | 2007-04-25 | 2013-11-26 | Proventiv Therapeutics, Llc | Methods and compounds for vitamin D therapy |
| HUE073014T2 (hu) | 2007-04-25 | 2025-12-28 | Opko Renal Llc | Eljárás a másodlagos hyperparathyreoidismus biztonságos és hatékony kezelésére és megelõzésére krónikus vesebetegség esetén |
| KR20190028822A (ko) | 2007-04-25 | 2019-03-19 | 사이토크로마 인코포레이티드 | 비타민 d 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물 |
| US20130079749A1 (en) * | 2007-08-29 | 2013-03-28 | Advanced Bionics, Llc | Modular Drug Delivery System for Minimizing Trauma During and After Insertion of a Cochlear Lead |
| RU2453332C2 (ru) | 2007-10-16 | 2012-06-20 | Байокон Лимитид | Твердая фармацевтическая композиция (варианты) и способ контроля концентрации глюкозы с ее помощью, способ получения твердой фармацевтической композиции (варианты), таблетка (варианты) и способ получения амфорных частиц |
| EP2281058B1 (en) | 2008-04-02 | 2016-06-29 | Opko Ireland Global Holdings, Ltd. | Methods, compositions, uses, and kits useful for vitamin d deficiency and related disorders |
| BR112012002271B1 (pt) | 2009-07-31 | 2020-06-16 | Merial, Inc | Cápsulas de liberação sustentada |
| WO2011123476A1 (en) | 2010-03-29 | 2011-10-06 | Cytochroma Inc. | Methods and compositions for reducing parathyroid levels |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 d 방출 제형 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| JP7032322B2 (ja) | 2016-03-28 | 2022-03-08 | オプコ アイルランド グローバル ホールディングス リミテッド | ビタミンd治療法 |
| EP4208157A1 (en) | 2020-09-04 | 2023-07-12 | Elanco Us Inc. | Palatable formulations |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2340037A (en) * | 1941-09-08 | 1944-01-25 | Zipper Alfred Irving | Capsule |
| FR1540258A (fr) * | 1964-11-30 | 1968-09-27 | Magnesium Elektron Ltd | Pastilles pour ruminants comportant un corps creux en magnésium ou alliage de magnésium |
| IL38538A (en) * | 1971-01-13 | 1974-09-10 | Alza Corp | Osmotic dispenser |
| US3760804A (en) * | 1971-01-13 | 1973-09-25 | Alza Corp | Improved osmotic dispenser employing magnesium sulphate and magnesium chloride |
| US4034756A (en) * | 1971-01-13 | 1977-07-12 | Alza Corporation | Osmotically driven fluid dispenser |
| US3732865A (en) * | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
| US3769895A (en) * | 1971-06-09 | 1973-11-06 | Teletype Corp | Masking for printed circuit photomasters |
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3929132A (en) * | 1973-04-10 | 1975-12-30 | Alza Corp | Osmotic dispenser |
| US3995632A (en) * | 1973-05-04 | 1976-12-07 | Alza Corporation | Osmotic dispenser |
| US4178361A (en) * | 1973-09-10 | 1979-12-11 | Union Corporation | Sustained release pharmaceutical composition |
| GB1478759A (en) * | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| DE2729068A1 (de) * | 1977-06-28 | 1979-01-11 | Rainer Dr Med Liedtke | Verfahren zur freisetzungssteuerung von arzneimitteln aus kapseln |
| US4196187A (en) * | 1977-09-02 | 1980-04-01 | Eastman Kodak Company | Rumen-stable pellets |
| US4199569A (en) * | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4200098A (en) * | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
| US4285987A (en) * | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
| FI63335B (fi) * | 1979-02-02 | 1983-02-28 | Orion Yhtymae Oy | Foerfarande foer framstaellning av tabletter med foerdroejd loslighet av effektaemne |
| US4235236A (en) * | 1979-02-12 | 1980-11-25 | Alza Corporation | Device for dispensing drug by combined diffusional and osmotic operations |
| US4320759A (en) * | 1980-04-28 | 1982-03-23 | Alza Corporation | Dispenser with diffuser |
| US4389397A (en) * | 1980-08-04 | 1983-06-21 | Merck & Co., Inc. | Solubilization of ivermectin in water |
| AU591171B2 (en) * | 1983-11-02 | 1989-11-30 | Alza Corporation | Dispenser for delivering thermo-responsive composition |
| US4595583A (en) * | 1984-03-19 | 1986-06-17 | Alza Corporation | Delivery system controlled administration of beneficial agent to ruminants |
| FR2565102B1 (fr) * | 1984-06-05 | 1987-03-20 | Paris Sud Universite | Microcapsules biodegradables a base de serumalbumine, leur preparation et leur application a la liberation in situ de medicuments |
| JPH0641406A (ja) * | 1992-07-23 | 1994-02-15 | Teijin Ltd | 難燃性ポリエステル樹脂組成物 |
-
1985
- 1985-08-08 US US06/763,493 patent/US4684524A/en not_active Expired - Lifetime
-
1986
- 1986-06-20 ES ES556375A patent/ES8802113A1/es not_active Expired
- 1986-07-30 NZ NZ217024A patent/NZ217024A/xx unknown
- 1986-07-30 GB GB8618568A patent/GB2178660B/en not_active Expired
- 1986-07-31 JP JP61181189A patent/JPH0759497B2/ja not_active Expired - Fee Related
- 1986-08-01 AU AU60780/86A patent/AU590308B2/en not_active Expired
- 1986-08-01 NL NL8601981A patent/NL8601981A/nl unknown
- 1986-08-01 DE DE3626103A patent/DE3626103C2/de not_active Expired - Lifetime
- 1986-08-06 FR FR868611371A patent/FR2585951B1/fr not_active Expired
- 1986-08-06 BR BR8603756A patent/BR8603756A/pt not_active IP Right Cessation
- 1986-08-07 CA CA000515469A patent/CA1265966A/en not_active Expired - Lifetime
- 1986-08-08 ZA ZA865982A patent/ZA865982B/xx unknown
- 1986-08-08 IT IT67646/86A patent/IT1195819B/it active
- 1986-08-08 BE BE0/217033A patent/BE905255A/fr not_active IP Right Cessation
-
1991
- 1991-11-14 AU AU87886/91A patent/AU8788691A/en not_active Abandoned
- 1991-12-16 AU AU89738/91A patent/AU654515B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| FR2585951A1 (fr) | 1987-02-13 |
| BE905255A (fr) | 1986-12-01 |
| AU590308B2 (en) | 1989-11-02 |
| AU654515B2 (en) | 1994-11-10 |
| JPH0759497B2 (ja) | 1995-06-28 |
| GB2178660A (en) | 1987-02-18 |
| NL8601981A (nl) | 1987-03-02 |
| IT1195819B (it) | 1988-10-27 |
| US4684524A (en) | 1987-08-04 |
| AU8788691A (en) | 1992-01-16 |
| AU8973891A (en) | 1992-02-13 |
| IT8667646A0 (it) | 1986-08-08 |
| GB2178660B (en) | 1989-09-06 |
| AU6078086A (en) | 1987-02-12 |
| NZ217024A (en) | 1989-07-27 |
| FR2585951B1 (fr) | 1989-03-03 |
| CA1265966A (en) | 1990-02-20 |
| ES556375A0 (es) | 1988-04-01 |
| DE3626103C2 (de) | 1998-02-19 |
| ZA865982B (en) | 1987-04-29 |
| JPS6239519A (ja) | 1987-02-20 |
| GB8618568D0 (en) | 1986-09-10 |
| DE3626103A1 (de) | 1987-02-12 |
| BR8603756A (pt) | 1987-03-10 |
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Legal Events
| Date | Code | Title | Description |
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| FD2A | Announcement of lapse in spain |
Effective date: 20151230 |