ES8802249A1 - Un procedimiento para el aislamiento de un gen de relaxina de un ser humano u otro primate o de una especie relacionada - Google Patents
Un procedimiento para el aislamiento de un gen de relaxina de un ser humano u otro primate o de una especie relacionadaInfo
- Publication number
- ES8802249A1 ES8802249A1 ES544293A ES544293A ES8802249A1 ES 8802249 A1 ES8802249 A1 ES 8802249A1 ES 544293 A ES544293 A ES 544293A ES 544293 A ES544293 A ES 544293A ES 8802249 A1 ES8802249 A1 ES 8802249A1
- Authority
- ES
- Spain
- Prior art keywords
- relaxin
- gene
- human
- chain
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical compound C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000012512 characterization method Methods 0.000 title 1
- 238000010369 molecular cloning Methods 0.000 title 1
- 239000013598 vector Substances 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108090000103 Relaxin Proteins 0.000 abstract 2
- 101001091088 Homo sapiens Prorelaxin H2 Proteins 0.000 abstract 1
- 241000288906 Primates Species 0.000 abstract 1
- 102000003743 Relaxin Human genes 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Reproductive Health (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO PARA EL AISLAMIENTO DE UN GEN DE RELAXINA DE UN SER HUMANO U OTRO PRIMATE O DE UNA ESPECIE RELACIONADA, EN QUE: A) AISLAR MARN; B) PREPARAR ADN DE DOBLE CADENA (CADN) A PARTIR DEL MARN; C) INSERTAR EL CADN EN UN VECTOR DE TRANSFERENCIA APROPIADO PARA DAR UN VECTOR DE TRANSFERENCIA RECOMBINANTE; D) TRANSFORMAR CELULAS HOSPEDANTES CON LOS VECTORES DE TRANSFERENCIA RECOMBINANTES; Y E) HIBRIDAR LOS VECTORES DE TRANSFERENCIA RECOMBINANTES CON UNA SONDA DE HIBRIDACION MARCADA CORRESPONDIENTE A UNA SUBUNIDAD O FRAGMENTO DEL GEN DE RELAXINA -H2 HUMANA, QUE COMPRENDE NUCLEOTIDOS DE LA REGION DE CODIFICACION DEL PEPTIDO G/PEPTIDO A DEL ADN, PARA IDENTIFICAR UN GEN QUE CONTIENE RELAXINA, Y AISLAR DICHO GEN. TIENE APLICACION EN LA PRODUCCION DE RELAXINA HUMANA CON FINES TERAPEUTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPF724782 | 1982-12-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES544293A0 ES544293A0 (es) | 1988-04-16 |
| ES8802249A1 true ES8802249A1 (es) | 1988-04-16 |
Family
ID=3769889
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES527964A Expired ES8602133A1 (es) | 1982-12-13 | 1983-12-12 | Un procedimiento para preparar un vector de transferencias de adn |
| ES544293A Expired ES8802249A1 (es) | 1982-12-13 | 1985-06-17 | Un procedimiento para el aislamiento de un gen de relaxina de un ser humano u otro primate o de una especie relacionada |
| ES552093A Expired ES8708016A1 (es) | 1982-12-13 | 1986-02-17 | Un procedimiento para sintetizar una secuencia de aminoacidos que contienen la totalidad o parte de la secuencia de aminoacidos de la preprorrelaxina -h2 humana. |
| ES552095A Expired ES8801373A1 (es) | 1982-12-13 | 1986-02-17 | Un procedimiento para aislar un gen de preprorrelaxina -h2 humana o un equivalente o subunidad del mismo |
| ES552094A Expired ES8708015A1 (es) | 1982-12-13 | 1986-02-17 | Un procedimiento para preparar relaxina -h2 humana o uno de sus analogos |
| ES557531A Expired ES8801675A1 (es) | 1982-12-13 | 1987-05-11 | Un procedimiento para preparar relaxina-h2 humana |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES527964A Expired ES8602133A1 (es) | 1982-12-13 | 1983-12-12 | Un procedimiento para preparar un vector de transferencias de adn |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES552093A Expired ES8708016A1 (es) | 1982-12-13 | 1986-02-17 | Un procedimiento para sintetizar una secuencia de aminoacidos que contienen la totalidad o parte de la secuencia de aminoacidos de la preprorrelaxina -h2 humana. |
| ES552095A Expired ES8801373A1 (es) | 1982-12-13 | 1986-02-17 | Un procedimiento para aislar un gen de preprorrelaxina -h2 humana o un equivalente o subunidad del mismo |
| ES552094A Expired ES8708015A1 (es) | 1982-12-13 | 1986-02-17 | Un procedimiento para preparar relaxina -h2 humana o uno de sus analogos |
| ES557531A Expired ES8801675A1 (es) | 1982-12-13 | 1987-05-11 | Un procedimiento para preparar relaxina-h2 humana |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4758516A (es) |
| EP (2) | EP0303033B1 (es) |
| JP (3) | JP2545055B2 (es) |
| KR (1) | KR940002536B1 (es) |
| AT (2) | ATE90360T1 (es) |
| CA (1) | CA1220735A (es) |
| DE (1) | DE3382249D1 (es) |
| DK (2) | DK171684B1 (es) |
| ES (6) | ES8602133A1 (es) |
| HU (1) | HU197767B (es) |
| IE (1) | IE63902B1 (es) |
| IL (1) | IL70414A (es) |
| NZ (1) | NZ206534A (es) |
| ZA (1) | ZA839231B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0101309B1 (en) * | 1982-08-12 | 1991-01-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Molecular cloning and characterization of a gene sequence coding for human relaxin |
| US5179195A (en) * | 1982-12-13 | 1993-01-12 | Howard Florey Institute Of Experimental Physiology And Medicine | Human relaxin polypeptides |
| US4835251A (en) * | 1986-06-23 | 1989-05-30 | Genetech, Inc. | Method of chain combination |
| NZ221789A (en) * | 1986-09-12 | 1991-05-28 | Genentech Inc | Recombinant prorelaxin, its preparation and pharmaceutical compositions comprising it |
| AU626840B2 (en) * | 1988-02-26 | 1992-08-13 | Genentech Inc. | Human relaxin formulation |
| CA2051375C (en) * | 1989-05-04 | 2000-09-12 | Dennis J. Henner | Process and compositions for the isolation of human relaxin |
| US5089419A (en) * | 1989-08-07 | 1992-02-18 | International Canine Genetics | Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals |
| US5478807A (en) * | 1991-08-19 | 1995-12-26 | Genentech, Inc. | Use of relaxin in the treatment of bradycardia |
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| AU3123393A (en) * | 1991-10-28 | 1993-06-07 | Board Of Regents, The University Of Texas System | A method for detecting a differentiation marker in normal and carcinoma cells and in biological samples and body fluid |
| US6348327B1 (en) | 1991-12-06 | 2002-02-19 | Genentech, Inc. | Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells |
| WO1995000645A2 (en) * | 1993-06-21 | 1995-01-05 | Genentech, Inc. | Process for producing relaxin |
| US20050032683A1 (en) | 2000-10-04 | 2005-02-10 | Amento Edward P. | Methods of modulating apoptosis by administration of relaxin agonists or antagonists |
| US20040006205A1 (en) * | 2001-04-03 | 2004-01-08 | Li Li | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| AU2002324727A1 (en) * | 2001-08-17 | 2003-03-03 | The Board Of Trustees Of The Leland Stanford Junior University | Mammalian relaxin receptors |
| AU2003903124A0 (en) * | 2003-06-20 | 2003-07-10 | Mark Del Borgo | Analogues of heteromeric proteins |
| JP4836942B2 (ja) * | 2004-04-30 | 2011-12-14 | コーセラ， インコーポレイテッド | リラキシンの調節による胎仔の発育の制御のための方法および組成物 |
| US20060052304A1 (en) * | 2004-09-02 | 2006-03-09 | Bas Medical, Inc. | Method for remodeling bone and related sutures |
| RU2501573C2 (ru) * | 2008-05-16 | 2013-12-20 | Кортера, Инк. | Способ предупреждения преждевременных родов |
| GR1006941B (el) | 2009-06-01 | 2010-08-27 | Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), | Πεπτιδικη συνθεση (peptide synthesis) |
| US8389475B2 (en) | 2009-08-10 | 2013-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Relaxin analogs |
| EA030886B1 (ru) | 2010-08-17 | 2018-10-31 | Амбркс, Инк. | Модифицированные полипептиды релаксина, содержащие некодируемую в природе аминокислоту, связанную с полимером, и их применение |
| RU2014103288A (ru) * | 2011-07-01 | 2015-08-10 | Байер Интеллектчуал Проперти Гмбх | Слитые полипептиды релаксина и их применение |
| EP2630964A1 (en) | 2012-02-22 | 2013-08-28 | Immundiagnostik AG | Method and medicament for treating patients in risk of prediabetes and type-2 diabetes |
| EP3068891A1 (en) | 2013-11-13 | 2016-09-21 | Aequus Biopharma Inc. | Engineered glycoproteins and uses thereof |
| EP2946788A1 (en) | 2014-05-23 | 2015-11-25 | Immundiagnostik AG | Method and composition for treating heart failure with preserved ejection fraction |
| IL263079B2 (en) | 2016-05-18 | 2024-05-01 | Modernatx Inc | Polynucleotides encoding relaxin |
| PE20191716A1 (es) | 2017-02-08 | 2019-12-05 | Bristol Myers Squibb Co | Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4468464A (en) * | 1974-11-04 | 1984-08-28 | The Board Of Trustees Of The Leland Stanford Junior University | Biologically functional molecular chimeras |
| GR70279B (es) * | 1979-09-12 | 1982-09-03 | Univ California | |
| US4267101A (en) * | 1980-02-01 | 1981-05-12 | Serono Laboratories Inc. | Process for obtaining human relaxin from fetal membranes |
| EP0068375A3 (en) * | 1981-06-22 | 1983-04-13 | G.D. Searle & Co. | Recombinant dna techniques for the production of relaxin |
| IE55479B1 (en) * | 1982-02-12 | 1990-09-26 | Florey Howard Inst | Molecular cloning and characterization of the gene sequence coding for porcine relaxin |
| EP0101309B1 (en) * | 1982-08-12 | 1991-01-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Molecular cloning and characterization of a gene sequence coding for human relaxin |
-
1983
- 1983-12-09 IL IL70414A patent/IL70414A/xx not_active IP Right Cessation
- 1983-12-09 NZ NZ206534A patent/NZ206534A/en unknown
- 1983-12-12 EP EP88110103A patent/EP0303033B1/en not_active Expired - Lifetime
- 1983-12-12 AT AT88110103T patent/ATE90360T1/de not_active IP Right Cessation
- 1983-12-12 ES ES527964A patent/ES8602133A1/es not_active Expired
- 1983-12-12 ZA ZA839231A patent/ZA839231B/xx unknown
- 1983-12-12 EP EP83307553A patent/EP0112149B1/en not_active Expired - Lifetime
- 1983-12-12 AT AT83307553T patent/ATE62507T1/de not_active IP Right Cessation
- 1983-12-12 CA CA000443049A patent/CA1220735A/en not_active Expired
- 1983-12-12 DE DE8383307553T patent/DE3382249D1/de not_active Expired - Lifetime
- 1983-12-12 IE IE290883A patent/IE63902B1/en not_active IP Right Cessation
- 1983-12-13 DK DK573783A patent/DK171684B1/da not_active IP Right Cessation
- 1983-12-13 JP JP58233744A patent/JP2545055B2/ja not_active Expired - Lifetime
- 1983-12-13 HU HU834243A patent/HU197767B/hu unknown
- 1983-12-13 KR KR1019830005905A patent/KR940002536B1/ko not_active Expired - Lifetime
- 1983-12-13 US US06/560,790 patent/US4758516A/en not_active Expired - Lifetime
-
1985
- 1985-06-17 ES ES544293A patent/ES8802249A1/es not_active Expired
-
1986
- 1986-02-17 ES ES552093A patent/ES8708016A1/es not_active Expired
- 1986-02-17 ES ES552095A patent/ES8801373A1/es not_active Expired
- 1986-02-17 ES ES552094A patent/ES8708015A1/es not_active Expired
-
1987
- 1987-05-11 ES ES557531A patent/ES8801675A1/es not_active Expired
-
1992
- 1992-11-30 DK DK143492A patent/DK172012B1/da not_active IP Right Cessation
-
1993
- 1993-03-22 JP JP5061747A patent/JP2677332B2/ja not_active Expired - Lifetime
-
1994
- 1994-10-26 JP JP6262254A patent/JP2891882B2/ja not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991007 |